Results 71 to 80 of about 16,499 (206)

Pattern of Serum Protein Electrophoresis: Advances in Laboratory Medicine

Journal of Medical Evidence
Serum protein electrophoresis (SPE) is an inexpensive laboratory technique employed to evaluate various serum proteins. SPE is used to identify the patients with clinical disorders of proteins such as multiple myeloma (MM), monoclonal and polyclonal ...
Akshita Singh Solanki, Nitin Sharma, Deepa Thadani   +2 more
doaj   +1 more source

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

Haematologica, 2017
Monoclonal gammopathy of undetermined significance is a pre-malignant precursor of multiple myeloma with a 1% risk of progression per year. Although targeted analyses have shown the presence of specific genetic abnormalities such as IGH translocations ...
Aneta Mikulasova, Christopher P. Wardell, Alexander Murison, Eileen M. Boyle, Graham H. Jackson, Jan Smetana, Zuzana Kufova, Ludek Pour, Viera Sandecka, Martina Almasi, Pavla Vsianska, Evzen Gregora, Petr Kuglik, Roman Hajek, Faith E. Davies, Gareth J. Morgan, Brian A. Walker   +16 more
doaj   +1 more source

The Burden of Small Fiber Neuropathy: Changes in Pain, Costs, and Quality of Life Before and After Diagnosis

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT Background and Aims Small fiber neuropathy (SFN) is a peripheral neuropathy causing neuropathic pain, reduced quality of life (QoL), and high societal costs. Previous studies assessed these societal costs before a definitive diagnosis was established, leaving it unclear whether diagnostic confirmation affects costs, pain intensity, or QoL ...
Dennis Kool, Margot Geerts, Lloyd Brandts, Merel Kimman, Caroline M. L. Gorissen‐Brouwers, Catharina G. Faber, Ingemar S. J. Merkies, Janneke G. J. Hoeijmakers   +7 more
wiley   +1 more source

PARAPROTEINEMIC POLYNEUROPATHY ASSOCIATED WITH MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE: СLINICAL CASE DESCRIPTION AND LITERATURE REVIEW

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2017
Monoclonal gammopathy of undetermined significance represents a number of conditions, the development of which is based on functional impairment of B-lymphocytes, which results in permanent pathological secretion of a single clone of immunoglobulins or ...
A. A. Yakovlev, E. S. Tarabanova, A. G. Smochilin, R. A. Gapeshin, M. V. Yakovleva   +4 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT

American Journal of Hematology, Volume 101, Issue 8, Page 1790-1798, August 2026.
ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack, Noah P. Splinter, Emily E. Mauch, Leben Tefera, Morayma Reyes Gil, Sakshi Jasra, Andrew Goodwin, Kristi J. Smock, Hadiyah Ahmad, Aneel Ashrani, Nathaniel L. Robinson, Ana I. Casanegra, Curtis G. Jones, Shannon M. Pechauer, Erin Yttre, Richard H. Aster, Mindy C. Kohlhagen, Rachel R. Leger, Gretchen Johns, David L. Murray, Lu Zhou, Demin Wang, Renren Wen, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan   +25 more
wiley   +1 more source

Primary Amyloidosis and a Case Report

مجله دانشکده پزشکی اصفهان, 2009
Background: Primary amyloidosis is the most common form of systemic Amyloidosis. Amyloidosis is the results of fibril formation due to plasma cell dyscrasia or rarely monoclonal gammopathy of uncertain significance (MGUS).
Hasan Vosoghinia, Maryam Sahebari, Masoumeh Salari, Afsoon Fazlinejad   +3 more
doaj  

Management of Patients With Hepatitis C Virus, Monoclonal Gammopathy of Undetermined Significance, and Multiple Myeloma

Journal of Investigative Medicine High Impact Case Reports, 2017
Background and Aim: The vast majority of the 2.7 million individuals in the United States who are currently infected with hepatitis C virus (HCV) were born between 1945 and 1965.
Alisse Hannaford BS, David Del Bello MD, Siyang Leng MD, Ajai Chari MD, PhD, Ponni Perumalswami MD, Douglas Dieterich MD, Andrea Branch PhD   +6 more
doaj   +1 more source

From Bone Pain to Severe Renal Symptoms: The Journey of a Patient With Multiple Myeloma and Brucellosis (Case Report)

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT In endemic regions, markedly elevated Brucella serologic titers with a dynamic decline after treatment support true infection even in the presence of monoclonal gammopathy. Concurrent infectious and malignant processes should be considered in patients presenting with severe renal failure and overlapping systemic symptoms to avoid diagnostic ...
Maryam Ghaffari Rahbar, Tahere Zarouk Ahimahalle, Marziyeh Ghalamkari, Maedeh Olya   +3 more
wiley   +1 more source

An Italian cartography of VEXAS‐related thrombosis

HemaSphere, Volume 10, Issue 8, August 2026.
Abstract Thrombotic events (TEs) occur in up to 40% of patients with vacuoles, E1 enzyme, X‐linked, autoinflammatory, and somatic (VEXAS) syndrome, but data on its clinical‐genomics features and anticoagulation strategies are limited. To gain more insight into this, we conducted a two‐step study evaluating the prevalence and outcome of TE in VEXAS ...
Giorgia Ranucci, Maria Rosaria Pascale, Vittorio Forte, Elisa Diral, Corrado Campochiaro, Jacqueline Ferrari, Mariachiara Cuccaro, Chiara Cattaneo, Francesca Crisafulli, Lucia Cardillo, Valeria Renola, Elisa Meddi, Marianna Velocci, Elisa Casciani, Francesca Romano, Pellegrino Musto, Serafina Barbato, Giorgia Battipaglia, Marco Frigeni, Erika Morsia, Arianna Savi, Cristina Papayannidis, Elena Crisà, Laura Cicconi, Isabella Capodanno, Alfonso Fiumarella, Antonio Pierini, Massimo Breccia, Giovanni Orsolini, Giulia Rivoli, Sara Bindoli, Davide Firinu, Antonio Vitale, Bruno Fattizzo, Monica Bocchia, Luca Cantarini, Chiara Pinton, Gabriele Todisco, Nicola Toschi, Paola Triggianese, Adriano Venditti, Maria Teresa Voso, Carmelo Gurnari   +42 more
wiley   +1 more source