Results 71 to 80 of about 13,966 (231)

Immunophenotypic studies of monoclonal gammopathy of undetermined significance [PDF]

BMC Clinical Pathology, 2008
Monoclonal gammopathy of undetermined significance (MGUS) is a common plasma cell dyscrasia, comprising the most indolent form of monoclonal gammopathy. However, approximately 25% of MGUS cases ultimately progress to plasma cell myeloma (PCM) or related diseases. It is difficult to predict which subset of patients will transform.
Olteanu, Horatiu, Wang, Huan-You, Chen, Weina, McKenna, Robert W, Karandikar, Nitin J   +4 more
openaire   +2 more sources

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, Volume 78, Issue 1, Page 12-25, January 2026.
Castleman disease (CD) is a major diagnostic challenge for rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region, whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y. C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells

Haematologica, 2013
Cytogenetic studies in clonal plasma cell disorders have mainly been done in whole bone marrow or CD138+ microbead-enriched plasma cells and suggest that recurrent immunoglobulin heavy chain translocations - e.g.
Martin Schmidt-Hieber, María Laura Gutiérrez, Martin Pérez-Andrés, Bruno Paiva, Ana Rasillo, Maria Dolores Tabernero, José Maria Sayagués, Antonio Lopez, Paloma Bárcena, María Luz Sanchez, Norma C. Gutiérrez, Jesus F. San Miguel, Alberto Orfao   +12 more
doaj   +1 more source

Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma.

JAMA Oncology, 2019
Importance Multiple myeloma is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS). Risk models that estimate the risk of progression from MGUS to multiple myeloma use data from a single time point, usually the initial ...
O. Landgren, J. Hofmann, C. McShane, L. Santo, M. Hultcrantz, N. Korde, S. Mailankody, D. Kazandjian, K. Murata, K. Thoren, L. Ramanathan, A. Dogan, E. Rustad, Sydney X Lu, T. Akhlaghi, S. Kristinsson, M. Björkholm, S. Devlin, M. Purdue, R. Pfeiffer, I. Turesson   +20 more
semanticscholar   +1 more source

Metabolomic and Lipidomic Profiling of Bone Marrow Plasma Differentiates Patients with Monoclonal Gammopathy of Undetermined Significance from Multiple Myeloma

Scientific Reports, 2020
Oncogenic drivers of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) such as c-MYC have downstream effects on intracellular metabolic pathways of clonal plasma cells (PCs).
W. Gonsalves, Katarzyna A. Broniowska, Erik Jessen, Xuan-Mai T. Petterson, A. G. Bush, Jaime Gransee, M. Lacy, T. Hitosugi, Shaji K. Kumar   +8 more
semanticscholar   +1 more source

Extranodal Lymphoplasmacytic Lymphoma Responding Rapidly to Zanubrutinib: A Case Series

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Management of recurrent or atypical lymphoplasmacytic lymphoma poses a significant therapeutic challenge. Here we demonstrate a case series of three patients with atypical presentations of extranodal lymphoplasmacytic lymphoma that each show remarkable and timely responses to Zanubrutinib with a limited side effect profile.
Samuel Brown, Jillian Rusbridge, George Follows, Anna Santarsieri   +3 more
wiley   +1 more source

Type-I Cryoglobulinaemia Associated to Monoclonal Gammapathy of Undetermined Significance

Prague Medical Report, 2020
Cryoglobulins are immunoglobulins that undergo reversible precipitation at cold temperatures. Monoclonal type-I cryoglobulinaemia is the least frequent and is associated to hematological diseases such as multiple myeloma, Waldenström’s macroglobulinaemia,
Juan Manuel Duarte, Paloma Ocampo, Silvia Graciela Ramos, Orlando Gabriel Carballo, Ricardo E. Barcia, Cecilia Elena Arévalo   +5 more
doaj   +1 more source

Circulating miRNAs as diagnostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance

Journal of clinical laboratory analysis (Print), 2020
Multiple myeloma (MM) is still an incurable hematological malignancy evolved from asymptomatic monoclonal gammopathy of undetermined significance (MGUS).
Jia Li, Man Zhang, Chengbin Wang
semanticscholar   +1 more source

When Autoimmunity Meets Malignancy: A Rare Case of Concomitant Systemic Lupus and Multiple Myeloma

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT The association between systemic lupus erythematosus (SLE) and multiple myeloma (MM) is rare, with fewer than 20 cases reported in the literature, raising questions about the link between chronic immune dysregulation and oncogenesis. We report the case of a 43‐year‐old Malagasy woman in whom a monoclonal β2‐globulin spike, incidentally ...
Solohery Jean Noël Ratsimbazafy, Havantsoa Nomena Fandresena Andrianarisambatra, Rajo Païdia Radinasoa, Hitsy Andraina Razafindrazaka, Tahianasoa Randriamampianina, Rija Mikhaël Miandrisoa, Fidiarivony Ralison, Hanta Marie Danielle Vololontiana   +7 more
wiley   +1 more source