Results 91 to 100 of about 130,905 (336)

Investigation of monocyte chemoattractant protein-1 (MCP-1) [PDF]

, 1991
Thesis (D.Sc.D.)--Boston University, Henry M. Goldman School of Graduate Dentistry (Oral Biology)Includes bibliography (leaves 54-66)Mononuclear phagocytes play a critical role in defending the host against foreign organisms and in regulating the ...
Jiang, Yanling
core  

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

URINARY EXCRETION OF IL-1β, MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND TRANSFORMING GROWTH FACTOR-

Медицинский вестник Юга России, 2015
Purpose: to evaluate the daily urinary excretion of markers of infl ammation (IL-1β, MCP-1) and transforming growth factor (TGF-β1) in women with type 1 diabetes with diff erent levels of daily albuminuria in diff erent trimesters of pregnancy.Materials ...
G. R. Gazizova, F. V. Valeeva, L. R. Gaysina   +2 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Triptolide down-regulates tumor necrosis factor-α and interferon-γ-induced overexpression of monocyte chemoattractant protein-1 in human proximal tubular epithelial cells

, 2002
ObjectiveTriptolide is the major active component of Tripterygium wilfordii Hook. f., which has been used as an anti-inflammatory agent in traditional Chinese medicine for centuries.
LIU, Dong, DAI, Chun-Sun, LI, Lei-Shi, LIU, Zhi-Hong, LI, Heng   +4 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet

Pharmaceutical Biology, 2018
Context: Polyphenols and flavonoids in artichoke leaf tincture (ALT) protect cells against oxidative damage. Objectives: We examined ALT effects on deoxyribonucleic acid (DNA) damage and lipid profiles in rat plasma and gene expression in rat aorta ...
Natasa Bogavac-Stanojevic, Jelena Kotur Stevuljevic, Darko Cerne, Janja Zupan, Janja Marc, Zorica Vujic, Milkica Crevar-Sakac, Miron Sopic, Jelena Munjas, Miroslav Radenkovic, Zorana Jelic-Ivanovic   +10 more
doaj   +1 more source

Hyperacute Interleukin‐1β Production and Neutrophil Extracellular Trap Formation in the Cerebral Circulation of Stroke Patients with Large Vessel Occlusion

Annals of Neurology, EarlyView.
Acute ischemic stroke due to large vessel occlusion is associated with rapid intravascular immune activation. Analysis of arterial blood sampled distal to the thrombus during mechanical thrombectomy revealed increased extracellular adenosine triphosphate (ATP) and interleukin‐1β (IL‐1β) levels, evidence of inflammasome priming in monocytes, and ...
Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa, Tim Magnus, Mathias Gelderblom   +33 more
wiley   +1 more source

Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity

Clinical Interventions in Aging, 2015
Objective Sarcopenic obesity (SO) is associated with poorer physical outcomes and functional status in the older adult. A proinflammatory milieu associated with central obesity is postulated to enhance muscle catabolism.
J. Lim, B. Leung, Y. Ding, L. Tay, N. H. Ismail, A. Yeo, S. Yew, M. Chong   +7 more
semanticscholar   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source