Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]
, 2002 Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
George K. Tofaris +7 more
core +1 more source
Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]
, 2009 Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Alexander Georg Khandoga +15 more
core +1 more source
The utility of biomarkers in the discrimination of acute coronary syndrome patients [PDF]
Journal of Bioscience and Applied Research, 2019 Background: The assessment of acute coronary syndrome (ACS) provides useful data not only for identification but also for therapeutic decisions. Objective: To develop a score based on cardiac biomarker for the early diagnosis of ACS patients.
Mohamed Omran +4 more
doaj +1 more source
Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. [PDF]
PLoS ONE, 2014 In abdominal aortic aneurysm (AAA), macrophages are detected in the proximity of aortic smooth muscle cells (SMCs). We have previously demonstrated in a murine model of AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1 ...
Qiwei Wang +5 more
doaj +1 more source
Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer [PDF]
Journal of Oncology, 2011 Background/Aims.Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients.Methods.ELISA was used to ...
Sullivan, Jennifer +6 more
openaire +2 more sources
Monocyte chemoattractant protein-1 and the blood–brain barrier [PDF]
Cellular and Molecular Life Sciences, 2013 The blood-brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation,
Yao, Yao, Stella E, Tsirka
openaire +2 more sources
How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?
Protein & Cell, 2020 Cytokines are secreted by various cell types and act as critical mediators in many physiological processes, including immune response and tumor progression. Cytokines production is precisely and timely regulated by multiple mechanisms at different levels,
Ruyi Xu +7 more
doaj +1 more source
PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages. [PDF]
PLoS Neglected Tropical Diseases, 2013 Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy
Louis de Léséleuc +12 more
doaj +1 more source
Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1 [PDF]
International Journal of Cancer, 1999 Almost any growth of tumors is to some extent associated with an inflammatory reaction which may be anti-tumorigenic by acting directly on tumor cells or protumorigenic cells presumably by inducing tumor-associated angiogenesis. In this study, we have analyzed the angiogenesis-inducing capacity of monocyte chemoattractant protein-1 (MCP-1), a key ...
Goede, V. +3 more
openaire +3 more sources
Production of Monocyte Chemoattractant Protein 1 in Tuberculosis Patients [PDF]
Infection and Immunity, 1998 ABSTRACTTo investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response toMycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+monocytes from healthy tuberculin reactors. MCP-
Y, Lin +4 more
openaire +2 more sources