Results 31 to 40 of about 130,905 (336)

The utility of biomarkers in the discrimination of acute coronary syndrome patients [PDF]

Journal of Bioscience and Applied Research, 2019
Background: The assessment of acute coronary syndrome (ACS) provides useful data not only for identification but also for therapeutic decisions. Objective: To develop a score based on cardiac biomarker for the early diagnosis of ACS patients.
Mohamed Omran, Faten Zahran, Mohamed Kadry, Arafa Belal, Hesham Abd Alsamie   +4 more
doaj   +1 more source

Genetically Determined Levels of Circulating Cytokines and Risk of Stroke: Role of Monocyte Chemoattractant Protein-1

Circulation, 2019
Background: Cytokines and growth factors have been implicated in the initiation and propagation of vascular disease. Observational studies have shown associations of their circulating levels with stroke.
Marios K. Georgakis, D. Gill, Kristiina Rannikmäe, M. Traylor, C. Anderson, J. Lee, Y. Kamatani, J. Hopewell, B. Worrall, J. Bernhagen, C. Sudlow, R. Malik, M. Dichgans   +12 more
semanticscholar   +1 more source

Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. [PDF]

PLoS ONE, 2014
In abdominal aortic aneurysm (AAA), macrophages are detected in the proximity of aortic smooth muscle cells (SMCs). We have previously demonstrated in a murine model of AAA that apoptotic SMCs attract monocytes and other leukocytes by producing MCP-1 ...
Qiwei Wang, Jun Ren, Stephanie Morgan, Zhenjie Liu, Changlin Dou, Bo Liu   +5 more
doaj   +1 more source

Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke: A Meta-Analysis of Population-Based Studies Involving 17,180 Individuals.

Circulation Research, 2019
RATIONALE Pro-inflammatory cytokines have been identified as potential targets for lowering vascular risk. Experimental evidence and Mendelian randomization suggest a role of monocyte-chemoattractant protein-1 (MCP-1) in atherosclerosis and stroke ...
Marios K. Georgakis, R. Malik, H. Björkbacka, T. Pana, S. Demissie, C. Ayers, M. Elhadad, M. Fornage, A. Beiser, E. Benjamin, M. Boekholdt, G. Engström, C. Herder, R. Hoogeveen, W. Koenig, O. Melander, M. Orho-Melander, A. Schiopu, Martin Söderholm, N. Wareham, C. Ballantyne, A. Peters, S. Seshadri, P. Myint, J. Nilsson, J. D. de Lemos, M. Dichgans   +26 more
semanticscholar   +1 more source

Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer [PDF]

Journal of Oncology, 2011
Background/Aims.Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients.Methods.ELISA was used to ...
Sullivan, Jennifer, Gong, Qiaoke, Hyslop, Terry, Lavu, Harish, Chipitsyna, Galina, Yeo, Charles, Arafat, Hwyda A   +6 more
openaire   +2 more sources

PARK2 mediates interleukin 6 and monocyte chemoattractant protein 1 production by human macrophages. [PDF]

PLoS Neglected Tropical Diseases, 2013
Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy
Louis de Léséleuc, Marianna Orlova, Aurelie Cobat, Manon Girard, Nguyen Thu Huong, Nguyen Ngoc Ba, Nguyen Van Thuc, Richard Truman, John S Spencer, Linda Adams, Vu Hong Thai, Alexandre Alcais, Erwin Schurr   +12 more
doaj   +1 more source

Abnormalities in Monocyte Recruitment and Cytokine Expression in Monocyte Chemoattractant Protein 1–deficient Mice

Journal of Experimental Medicine, 1998
Monocyte chemoattractant protein 1 (MCP-1) is a CC chemokine that attracts monocytes, memory T lymphocytes, and natural killer cells. Because other chemokines have similar target cell specificities and because CCR2, a cloned MCP-1 receptor, binds other ...
B. Lu, B. Rutledge, L. Gu, J. Fiorillo, N. Lukacs, S. Kunkel, R. North, C. Gerard, B. Rollins   +8 more
semanticscholar   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

How are MCPIP1 and cytokines mutually regulated in cancer-related immunity?

Protein & Cell, 2020
Cytokines are secreted by various cell types and act as critical mediators in many physiological processes, including immune response and tumor progression. Cytokines production is precisely and timely regulated by multiple mechanisms at different levels,
Ruyi Xu, Yi Li, Yang Liu, Jianwei Qu, Wen Cao, Enfan Zhang, Jingsong He, Zhen Cai   +7 more
doaj   +1 more source

Monocyte chemoattractant protein-1 and the blood–brain barrier [PDF]

Cellular and Molecular Life Sciences, 2013
The blood-brain barrier (BBB) is a dynamic structure that maintains the homeostasis of the brain and thus proper neurological functions. BBB compromise has been found in many pathological conditions, including neuroinflammation. Monocyte chemoattractant protein-1 (MCP1), a chemokine that is transiently and significantly up-regulated during inflammation,
Yao, Yao, Stella E, Tsirka
openaire   +2 more sources