Results 31 to 40 of about 32,111,831 (291)

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Мonocyte Chemoattractant Protein Levels in Patients with Primary Hypothyroidism

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
Objective of the research — to study the content of monocyte chemoattractant protein‑1 (MCP‑1) in the urine of patients with primary hypothyroidism. Materials and methods. 141 patients with overt hypothyroidism have been examined. Among them, 71 patients
O.M. Didushko
doaj   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Monocyte chemoattractant protein 1 in obesity and insulin resistance [PDF]

Proceedings of the National Academy of Sciences, 2003
This study identifies monocyte chemoattractant protein 1 (MCP-1) as an insulin-responsive gene. It also shows that insulin induces substantial expression and secretion of MCP-1 both in vitro in insulin-resistant (IR) 3T3-L1 adipocytes and in vivo in ...
Peter, Sartipy, David J, Loskutoff
openaire   +2 more sources

Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women

Journal of Obesity & Metabolic Syndrome, 2017
Background : Monocyte chemoattractant protein-1 (MCP-1) is expressed in adipose tissue, macrophages, endothelial cells, and osteoblasts by parathyroid hormone administration.
Seong-Kyu Lee
doaj   +1 more source

Monocyte chemoattractant protein‐1 and coronary artery disease [PDF]

Clinical Cardiology, 2002
AbstractThe designation of atherosclerosis as a chronic inflammatory process represents an exciting and logical paradigm shift for cardiologists. Monocyte chemoattractant protein‐1 (MCP‐1) plays an important role in the recruitment and activation of monocytes and thus in the development of atherosclerosis. Enhanced MCP‐1 expression has been detected in
Uichi, Ikeda, Keiji, Matsui, Yoshiaki, Murakami, Kazuyuki, Shimada   +3 more
openaire   +2 more sources

Evaluation of TGF-β1 and MCP-1 expression and tubulointerstitial fibrosis in children with Henoch-Schönlein purpura nephritis and IgA nephropathy: A clinical correlation

Clinics
OBJECTIVES: Henoch-Schönlein purpura nephritis and immunoglobulin A nephropathy are two diseases with similar clinical presentations but very different prognoses.
Zhao Shuiai, Shen Huijun, Gu Weizhong, Liu Aimin, Mao Jianhua   +4 more
doaj   +1 more source

P2Y6 receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells [PDF]

, 2014
This work is supported the British Heart Foundation [grant number PG/13/22/ 30077]. Deposited in PMC for immediate release.The chemokine CCL2 serves to target circulating monocytes and other leukocytes to tissue during innate immune responses, and ...
Campwala, H., Fountain, Samuel J., Sexton, D. W., Campwala, Hinnah, Fountain, SJ, Crossman, David C., Sexton, Darren W., Campwala, H, Crossman, D. C., Fountain, S. J., Sexton, DW, Crossman, DC   +11 more
core   +1 more source

Staphylococcus aureus regulates secretion of interleukin-6 and monocyte chemoattractant protein-1 through activation of nuclear factor kappaB signaling pathway in human osteoblasts

Brazilian Journal of Infectious Diseases
OBJECTIVE: Activation of nuclear factor kappaB by diverse bacteria regulates the secretion of chemokines and cytokines. Staphylococcus aureus (S.
Rende Ning, Xianlong Zhang, Xiaokui Guo, Qingtian Li   +3 more
doaj   +1 more source

Unravelling the Influence of Demographic and Lifestyle Factors on Monocyte Chemoattractant Protein-1 in Diabetic Retinopathy Patients

Journal of Bahria University Medical and Dental College, 2023
Objectives: To determine the association of Monocyte chemoattractant protein-1 (MCP-1) level with Age, blood glucose level, Exercise, Gender and Smoking in diabetic retinopathy patients. Study Design and settings: A case-control study was carried in the
Shabeer Ahmed, Hammad Raziq, Noman Sadiq, Sana Soomro, Rubina Amjad, Wazir Ahmed Baloch   +5 more
doaj   +1 more source