Results 201 to 210 of about 176,233 (276)

The exploration to identify key molecules in the interaction between endothelial cells and mono-macrophages in atherosclerosis based on the single cell transcriptome. [PDF]

BMC Cardiovasc Disord
Li B, Zhu R, Gao N, Li S, Yang N, Wang H, Yu H, Lu Z, Sègbo AGJ, Zheng F.   +9 more
europepmc   +1 more source

Sensing‐Integrated Patient‐Derived Tumorspheres Predict Chemotherapeutic Efficacy via Local Extracellular pH Dynamics

Small, EarlyView.
The study introduces a 3D sensing‐integrated platform enabling real‐time, non‐invasive monitoring of pH dynamics in patient‐derived PDAC tumorspheres. It revealed distinct extracellular acidification patterns under FOLFIRINOX, gemcitabine, and paclitaxel, correlating with therapeutic efficacy.
Stefania Forciniti, Valentina Onesto, Anna Chiara Siciliano, Helena Iuele, Stefano D'Ugo, Norma Depalma, Cinzia Fasano, Alessandro D'Amuri, Giuseppe Gigli, Marcello G. Spampinato, Loretta L. del Mercato   +10 more
wiley   +1 more source

Injured proximal tubule-driven paracrine signaling promotes lipid-associated macrophage expansion and chondroitin sulfate biosynthesis via PPARG/TCF12 in diabetic kidney disease. [PDF]

Front Immunol
Wu B, Dou Z, Cai M, Fei S, Liu S, Mei X.
europepmc   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Characterization of Peripheral Blood Immune Cell Features in SSA/SSB Double‑Positive Primary Sjögren's Disease Based on Single‑Cell RNA Sequencing. [PDF]

J Inflamm Res
Wang P, Teng F, Wang Y, Ji W, Yu X, Chen G, Tao Q.   +6 more
europepmc   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

CD84 expression stratifies venetoclax response and reveals a targetable vulnerability in resistant acute myeloid leukemia. [PDF]

Exp Hematol Oncol
Wang X, Lin X, Chen T, Chen Y, Wang H, Zhu Y.   +5 more
europepmc   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

VIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan, Kathirvel Ayyaswamy, Parthasarathy Vellaichamy, Nagarajan Deivanayagam Pillai, Rithik Gobinath   +4 more
wiley   +1 more source

A Macrophage/Monocyte-Related Four-Gene Signature for Prognostic Assessment of Uveal Melanoma: <i>BTBD6</i>, <i>C2CD4B</i>, <i>CCL24</i>, and <i>S100A4</i>. [PDF]

Hum Mutat
Yu Y, Wang M, Zhao B.
europepmc   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

VIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source