Results 91 to 100 of about 79,932 (302)
From Interferon Signature to the Clinical Landscape: Type I Interferonopathies
Arthritis &Rheumatology, EarlyView.Objective TypeI interferonopathies are heterogeneous diseases driven by dysregulated type I interferon (IFN‐I) signaling. Diagnosis is challenging due to clinical/molecular variability and the need for IFN‐I quantification. The aim of this study was to characterize the clinical, immunologic, genetic, molecular profiles of patients with suspected ...
Ismail Yaz +13 more
wiley +1 more source
MONOGENICALLY STABLE POLYNOMIALS
Albanian Journal of Mathematics, 2021 Summary: A monic polynomial \(f(x) \in \mathbb{Z}[x]\) is called stable if \(f^n(x)\) is irreducible over \(\mathbb{Q}\) for all \(n \geq 1\), where \(f^n(x)\) denotes the \(n\)th iterate of \(f(x)\). Regardless of whether \(f(x)\) is irreducible over \(\mathbb{Q}\), if there exists some monic \(g(x) \in \mathbb{Z}[x]\) such that \(g(f^n(x))\) is ...
openaire +2 more sources
Feature detection from echocardiography images using local phase information [PDF]
, 2008 Ultrasound images are characterized by their special speckle appearance, low contrast, and low signal-to-noise ratio. It is always challenging to extract important clinical information from these images.
Rajpoot, Nasir M. (Nasir Mahmood) +3 more
core
Monogenic diabetes: could this be your patient?
, 2017 A correct diagnosis of monogenic diabetes can transform treatment options, writes Anita Murphy
Anita Murphy
core +1 more source
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by altered synaptic connectivity and network organization, resulting in profound impairments in social communication and interaction. Transcranial direct current stimulation (tDCS) represents a promising approach to modulate maladaptive plasticity associated with ASD;
Antonia Ramme +9 more
wiley +1 more source
Cauchy-Kowalevski extensions and monogenic plane waves in Clifford analysis [PDF]
, 2012 This paper deals with axially and biaxial monogenic functions that are derived using two fundamental methods of Clifford analysis, namely the Cauchy-Kowalevski extension and monogenic plane ...
De Schepper, Nele, Sommen, Franciscus
core +1 more source
Biotechnology and Bioengineering, EarlyView.Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga +2 more
wiley +1 more source
The monogenic primary dystonias [PDF]
Brain, 2009 Presently, 17 distinct monogenic primary dystonias referred to as dystonias 1- 4, 5a,b, 6-8, 10-13 and 15-18 (loci DYT 1-4, 5a,b, 6-8, 10-13, 15-18) have been recognized. Twelve forms are inherited as autosomal dominant, four as autosomal recessive and one as an X-linked recessive trait. Three additional autosomal dominant forms (DYT9, DYT19 and DYT20)
openaire +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Almost half of individuals with hypertension fail to achieve recommended blood pressure (BP) goals. Pharmacogenetic gene‐drug interactions may alter the efficacy of antihypertensive agents. We conducted a multicenter randomized controlled sub‐study of participants (N = 1874) with hypertension and self‐reported African ancestry to determine whether ...
Philip E. Empey +25 more
wiley +1 more source
Considerations for drug trials in hypertrophic cardiomyopathy
ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant +17 more
wiley +1 more source