Results 91 to 100 of about 1,130,327 (225)

Genomic screening for monogenic forms of diabetes [PDF]

BMC Medicine, 2018
Adult-onset, or type II diabetes mellitus (T2DM) has a complex genetic architecture, from hundreds of genes with low penetrance, common susceptibility variants (e.g., TCF7L2), to a set of more than ten genes that, when mutated, can cause a single-gene or Mendelian form of T2DM (e.g., GCK).
openaire   +3 more sources

Implementation and Phase 1 evaluation outcomes of the NHS England National Diabetes Transition and Young Adult Pilot Programme (2022–2026)

Diabetic Medicine, EarlyView.
Abstract Aims This programme was a 4‐year, centrally commissioned endeavour to gather evidence of strategies to implement a model service specification in 15 pilot sites and improve outcomes in 16‐ to 25‐year‐olds with diabetes. Methods Retrospective cohort study evaluating the quantitative and qualitative impact of implementing the model service ...
Reza Zaidi, Fulya Mehta, Partha Kar, Jonathan Valabhji, Verity Hawkes, Lucy Holmes, Karen Kennedy, Sheena Dungey, Mo Jaffer Ismail   +8 more
wiley   +1 more source

Insights from maturity-onset diabetes of the young into impaired insulin secretion in type 2 diabetes

Endocrine Journal
Monogenic diabetes arises from pathogenic variants in a single gene that are sufficient to cause disease predisposition. In general, a greater functional impact of genetic abnormalities is associated with an earlier age of onset.
Yukio Horikawa, Yoshihiro Takahashi, Kazuyoshi Hosomichi   +2 more
doaj   +1 more source

Use of Glucose‐Lowering Drugs for Type 2 Diabetes Among Danish Care Home Residents

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Care home admission often reflects frailty and limited life expectancy, potentially altering the benefit‐harm balance of glucose‐lowering drug (GLD) treatment for type 2 diabetes (T2D). Real‐world data on treatment patterns in this setting remain limited. We examined GLD use for T2D among Danish care home residents.
Hanin Harbi, Reimar W. Thomsen, Carina Lundby, Jacob Volmer Stidsen, Kurt Højlund, Jesper Ryg, Mette Reilev, Anton Pottegård   +7 more
wiley   +1 more source

Association Between the GMI/HbA1c Ratio and Microvascular Complications in Type 1 Diabetes: A Multicenter Cross‐Sectional Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Objective To clarify whether the glucose management indicator (GMI)/glycated haemoglobin (HbA1c) ratio (GMI/HbA1c ratio) is an independent predictor of microvascular complications in Type 1 diabetes (T1D). Design and Methods Multicentre, cross‐sectional, observational study including subjects with T1D with at least 5 years of evolution, users ...
Sandra Herranz‐Antolín, María Asunción Martínez‐Brocca, Gloria Cánovas‐Molina, Aurora Aragón‐Alonso, Miguel Brito‐Sanfiel, Jose Ignacio Martínez‐Montoro, Virginia Bellido, Sharona Azriel, María del Carmen López‐García, Cristina Tejera, Amparo Bartual, Verónica Perea, Pedro José Pines, Antonio J. Amor, Óscar Moreno‐Pérez, Rebeca Reyes‐García, Gema López‐Gallardo, María Durán‐Martínez, Cristina Serrano, Rosa Márquez‐Pardo, Noemí González‐Pérez de Villar, Manuel Gargallo, Estefanía Santos, Pedro Pujante, Jessica Ares, Diego Bellido, Ignacio Conget, Fernando Gomez‐Peralta   +27 more
wiley   +1 more source

Sleep patterns in adults and children with less common forms of diabetes

Frontiers in Endocrinology
ObjectiveTo review the current evidence on sleep patterns in relation to glucose control in adults and children with type 1 diabetes (T1DM) and monogenic diabetes.MethodsWe searched for the literature pertaining to T1DM and monogenic diabetes with ...
Marilyn Arosemena, Marilyn Arosemena, Maria V. Salguero, Siri Atma W. Greeley, Rochelle N. Naylor, Esra Tasali, Louis H. Philipson, Louis H. Philipson   +7 more
doaj   +1 more source

Genotype‐Dependent Functional and Pharmacological Profiling of Rare GCK Variants Reveals Implications for Precision Management of Monogenic Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Rare GCK variants contribute to heterogeneous forms of monogenic diabetes, yet the molecular basis underlying their diverse functional consequences and pharmacological responsiveness remains incompletely understood. As glucokinase (GCK) serves as a central glucose sensor in pancreatic β‐cells and hepatocytes, defining the functional ...
Haoyu Bai, Jie Yu, Qiusha Zhu, Xue Zhou, Ting Xie, Tong Wang, Jing Ren, Chuhan Shao, Qian Zhang, Changhong Li, Xinhua Xiao   +10 more
wiley   +1 more source

Genetics‐Informed Pharmacological Intervention in Gestational Diabetes Mellitus: Current Therapeutic Alignment, Emerging Targets and a Translational Roadmap

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Gestational diabetes mellitus (GDM) complicates roughly one in seven pregnancies and predicts later maternal type 2 diabetes mellitus (T2DM). Yet its pharmacological management still rests on a handful of agents (insulin, metformin and glibenclamide), none of them selected on the basis of the disease's molecular genetics.
Wael Osman
wiley   +1 more source

Monogenic diabetes: old and new approaches to diagnosis [PDF]

Clinical Medicine, 2013
Up to 5% of young adults diagnosed with diabetes have a monogenic aetiology, the most common of which is maturity-onset diabetes of the young (MODY). A definitive molecular diagnosis is important, as this affects treatment, prognosis and family screening.
openaire   +4 more sources

A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms [PDF]

Diabetes & Metabolism Journal
Background Recent diabetes subclassifications have improved the differentiation between patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus despite several overlapping features, yet without considering genetic forms of diabetes. We
Sophie Welsch, Antoine Harvengt, Paola Gallo, Manon Martin, Dominique Beckers, Thierry Mouraux, Nicole Seret, Marie-Christine Lebrethon, Raphaël Helaers, Pascal Brouillard, Miikka Vikkula, Philippe A. Lysy   +11 more
doaj   +1 more source