Results 101 to 110 of about 1,062,540 (244)

Use of Glucose‐Lowering Drugs for Type 2 Diabetes Among Danish Care Home Residents

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Care home admission often reflects frailty and limited life expectancy, potentially altering the benefit‐harm balance of glucose‐lowering drug (GLD) treatment for type 2 diabetes (T2D). Real‐world data on treatment patterns in this setting remain limited. We examined GLD use for T2D among Danish care home residents.
Hanin Harbi, Reimar W. Thomsen, Carina Lundby, Jacob Volmer Stidsen, Kurt Højlund, Jesper Ryg, Mette Reilev, Anton Pottegård   +7 more
wiley   +1 more source

Monogenic diabetes: old and new approaches to diagnosis [PDF]

Clinical Medicine, 2013
Up to 5% of young adults diagnosed with diabetes have a monogenic aetiology, the most common of which is maturity-onset diabetes of the young (MODY). A definitive molecular diagnosis is important, as this affects treatment, prognosis and family screening.
openaire   +4 more sources

Breast-Feeding and Childhood-Onset Type 1 Diabetes : A pooled analysis of individual participant data from 43 observational studies [PDF]

, 2012
OBJECTIVE To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS Relevant studies were identified
Cinek, O., Joner, Geir, Brigis, G, Parslow, Roger C, Joner, Geir,, Geir Joner (8519850), Schober, E, Stene, Lars C, Radon, K, Carine E de Beaufort (16166561), Devoti, Gabriele, Karavanaki, K, Rosenbauer, Joachim,, Cardwell, Chris R, Ponsonby, Anne-Louise, Stene, Lars C., Stene, Lars C,, Memon, Anjum, Joner, G, Savilahti, E., Ionescu-Tirgoviste, C., C Patterson, Chris,, Urbonaite, B., Devoti, G., Patterson, Chris C., Constantin Ionescu-Tirgoviste (542793), Memon, A., Wadsworth, EJ, Urbonaite, Brone,, Patterson, Christopher, Strotmeyer, ES, Urbonaite, Brone, Chetwynd, Amanda,, Cardwell, Christopher; id_orcid, Lee-Ming Chuang (215892), Svensson, Jannet, Pozzilli, Paolo, Perez-Bravo, Francisco,, Wadsworth, Emma J.K., Chuang, Lee-Ming,, Brone Urbonaite (16166552), Benson, Victoria,, Gimeno, S.G., de Beaufort, Carine E, Pozzilli, P., DE BEAUFORT, Carine, Stene, LC, C Patterson, Chris, Radon, Katja, Karavanaki, Kyriaki,, Svensson, J., Goldacre, MJ, Michael J Goldacre (8832635), Katja Radon (487886), Goldacre, Michael J,, 莊立民, Goldacre, Michael J., Benson, V, Gimeno, Suely Godoy Agostinho [UNIFESP], Ludvigsson, Johnny, Joner, G., Paolo Pozzilli (310706), Savilahti, Erkki, Sipetic, Sandra,, Schober, E., Sipetic, Sandra, Rabiei, S, Brigis, Girts,, Anjum Memon (4461844), de Beaufort, Carine E,, Svensson, J, Cinek, Ondrej, Mona Salem (16166564), Chuang, Lee-Ming, Benson, V., Sandra Sipetic (16166558), Salem, Mona, Elsa S Strotmeyer (16166546), Perez-Bravo, Francisco, Patterson, CC, Strotmeyer, E.S., Karavanaki, K., Salem, Mona,, Brigis, G., Wadsworth, Emma J K,, Cardwell, CR, Perez-Bravo, F, Victoria Benson (6821780), Karavanaki, Kyriaki, Girts Brigis (4725450), Chetwynd, Amanda, Schober, Edith,, Roger C Parslow (9861266), Goldacre, M.J., Kyriaki Karavanaki (336472), Rabiei, Samira,, Ionescu-Tirgoviste, Constantin,, Rabiei, Samira, De Beaufort, Carine E., Sipetic, S, Cinek, O, Chuang, LM, Patterson, Chris C, Rosenbauer, Joachim, Schober, Edith, Chetwynd, A., Memon, A, Gimeno, SG, Ondrej Cinek (196591), Harrild, K., Ponsonby, Anne-Louise,, Svensson, Jannet,, Anne-Louise Ponsonby (340858), Chuang, Lee Ming, Beaufort, Carine E. de, Chris R Cardwell (5356490), Jannet Svensson (418468), Chetwynd, A, Ionescu-Tirgoviste, Constantin, Savilahti, Erkki,, Lars C Stene (16166537), Suely G Gimeno (16166540), Memon, Anjum,, Ponsonby, AL, Strotmeyer, Elsa S, Brigis, Girts, Rosenbauer, J., Chris C Patterson (5364881), Radon, Katja,, Parslow, RC, Wadsworth, EJK, Emma J K Wadsworth (16166543), Harrild, K, Parslow, R.C., Cardwell, Chris R., De Beaufort, CE, Ionescu-Tirgoviste, C, Cardwell, Chris R,, Devoti, G, Cardwell, C.R., Salem, M., Samira Rabiei (16166567), Cardwell, Chris R.;Stene, Lars C.;Ludvigsson, Johnny;Rosenbauer, Joachim;Cinek, Ondrej;Svensson, Jannet;Perez-Bravo, Francisco;Memon, Anjum;Gimeno, Suely G.;Wadsworth, Emma J. K.;Strotmeyer, Elsa S.;Goldacre, Michael J.;Radon, Katja;Chuang, Lee-Ming;Parslow, Roger C.;Chetwynd, Amanda;Karavanaki, Kyriaki;Brigis, Girts;Pozzilli, Paolo;Urbonaite, Brone;Schober, Edith;Devoti, Gabriele;Sipetic, Sandra;Joner, Geir;Ionescu-Tirgoviste, Constantin;de Beaufort, Carine E.;Harrild, Kirsten;Benson, Victoria;Savilahti, Erkki;Ponsonby, Anne-Louise;Salem, Mona;Rabiei, Samira;Patterson, Chris C., Edith Schober (640994), Wadsworth, Emma J. K., Cinek, Ondrej,, Ponsonby, A.L., Ponsonby, Anne Louise, Ludvigsson, J, Savilahti, E, Francisco Perez-Bravo (206402), Parslow, Roger C., Johnny Ludvigsson (167260), Benson, Victoria, Amanda Chetwynd (16166549), Wadsworth, Emma J K, Parslow, Roger C,, Ludvigsson, J., Sipetic, S., Rabiei, S., Stene, L.C., Rosenbauer, J, Pozzilli, P, Chuang, L.M., Erkki Savilahti (68955), Strotmeyer, Elsa S., Urbonaite, B, Wadsworth, E.J., Strotmeyer, Elsa S,, Devoti, Gabriele,, Ludvigsson, Johnny,, Goldacre, Michael, Joachim Rosenbauer (445335), Gimeno, Suely G, Perez-Bravo, F., Radon, K., Patterson, C.C., Pozzilli, Paolo,, Harrild, Kirsten, Gimeno, Suely G,, Salem, M, Goldacre, Michael J, Gimeno, Suely G., Harrild, Kirsten,, Kirsten Harrild (563534), Gabriele Devoti (16166555)   +185 more
core   +1 more source

Polygenic Risk Modelling in Periodontitis: Insights From a Feasibility Study of 4243 European Cases and Current Limitations

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background and Aim Genetic susceptibility plays a particularly important role in early‐onset (EO) and severe periodontitis (PD). The genetic risk remains largely unexplained because of limited sample sizes and heterogeneous phenotypes in genome‐wide association studies (GWAS).
Gesa M. Richter, O. Mercy Akinloye, M. Kamal Nasr, Birte Holtfreter, Alicia de Coo, Silvia Diz De Almeida, Bruno G. Loos, Søren Jepsen, Henrik Dommisch, Corinna Bruckmann, Ines Kapferer‐Seebacher, PerioGEN Cohort Group, Georg Homuth, Thomas Kocher, Henry Völzke, Klaus Berger, Matthias Laudes, Wolfgang Lieb, Nathalie van der Velde, Natasja van Schoor, Lisette de Groot, Juan Blanco, Angel Carracedo, Raquel Cruz, Astrid Dempfle, Alexander Teumer, Arne S. Schaefer, Sandra Freitag‐Wolf   +27 more
wiley   +1 more source

A New Tool to Identify Pediatric Patients with Atypical Diabetes Associated with Gene Polymorphisms [PDF]

Diabetes & Metabolism Journal
Background Recent diabetes subclassifications have improved the differentiation between patients with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus despite several overlapping features, yet without considering genetic forms of diabetes. We
Sophie Welsch, Antoine Harvengt, Paola Gallo, Manon Martin, Dominique Beckers, Thierry Mouraux, Nicole Seret, Marie-Christine Lebrethon, Raphaël Helaers, Pascal Brouillard, Miikka Vikkula, Philippe A. Lysy   +11 more
doaj   +1 more source

Genetic basis of Asian diabetes

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Recent genomic studies in Asian populations have advanced our understanding of the diagnosis, pathophysiology, risk prediction, and precision care of diabetes. Monogenic diabetes, including maturity‐onset diabetes of the young (MODY) and mitochondrial diabetes, highlights the importance of genetic diagnosis for subtype‐specific care.
Takafumi Ojima, Toshimasa Yamauchi
wiley   +1 more source

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Molecular Metabolism, 2017
Background: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches.
Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea   +3 more
doaj   +1 more source

Darier disease—A review highlighting new insights from the Darier Disease International Task Force

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz, Alain Hovnanian, Grace Xiong, Dedee Frances Murrell, Simon M. Mueller, Khaled Ezzedine, Nessa Aghazadeh Mohandesi, Ahmed Salem Aldhaheri, Nissim Asayag, Eulalia Baselga, Chen Nadler, Keith Choate, Chia‐Yu Chu, John Robert Edminister, Emmanuella Guenova, Melis Gönülal, Antoni Gostynski, Ankan Gupta, Lalit Kumar Gupta, Juliette Mazereeuw‐Hautier, Wolfram Hoetzenecker, Peter Itin, Marek Jankowski, Akiharu Kubo, Haur Yueh Lee, Julia Scott Lehman, Anfisa Lepekhova, Márta Medvecz, Jemima E. Mellerio, Verena Moosbrugger‐Martinz, Amy S. Paller, Dóra Plázár, Amadeu José Rodrigues Queiróz, Josep Riera‐Monroig, Ralph Rosa, Matthias Schmuth, Maella Severino Freire, Itzhak Shabat, Jonathan Shapiro, Cory L. Simpson, Diego Soto‐García, Alexander J. Stratigos, Gianluca Abel Tadini, Takuya Takeichi, Kaushal K. Verma, Jakob D. Wikström, Alexander Zink, Michael Ziv, Alexander Navarini, Roni Pircha Dodiuk‐Gad   +49 more
wiley   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, EarlyView.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source

European Consortium for Lipodystrophies consensus definition and classification framework for monogenic lipodystrophy

Journal of Internal Medicine, EarlyView.
Abstract Lipodystrophy comprises a heterogeneous group of disorders characterized by reduced adipose tissue often associated with severe metabolic complications. Lipodystrophy may be genetic, acquired, or secondary to medical therapies initiated for other conditions.
Robert K. Semple, Martin Wabitsch, Baris Akinci, Saif Alyaarubi, Marjoleine F. Broekema, Rebecca J. Brown, Giovanni Ceccarini, Carolina Cecchetti, Solaf M. Elsayed, Antía Fernández‐Pombo, Alessandra Gambineri, Ingrid M. Jazet, Lotte Kleinendorst, Konstanze Miehle, Elif A. Oral, Flavia Prodam, Ferruccio Santini, David B. Savage, Nadia Shaukat Ali, Ekaterina Sorkina, Magdalena Szopa, Marie‐Christine Vantyghem, Camille Vatier, Corinne Vigouroux, Julia von Schnurbein, David Araújo‐Vilar   +25 more
wiley   +1 more source