Results 211 to 220 of about 85,555 (244)

CRYAB is compromised in pathologically affected oligodendrocytes in multiple system atrophy

Brain Pathology, EarlyView.
CRYAB is hypermethylated and colocalizes with α‐synuclein in multiple system atrophy oligodendrocytes.
Finula I. Isik, Jen‐Hsiang T. Hsiao, Felicia Xaveria Suteja, Shrey Shahdadpuri, Nicolas Dzamko, Glenda M. Halliday, Woojin Scott Kim, YuHong Fu   +7 more
wiley   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Structural analysis of Cu/Zn-superoxide dismutase linked to neurodegenerative disease by antibody-guided cryo-EM. [PDF]

Protein Sci
Shino Y, Muraki N, Kobatake Y, Kamishina H, Kosuge H, Nakakido M, Tsumoto K, Furukawa Y.   +7 more
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Powdered hibiscus anthocyanin‐nanofibril complexes as natural colourants: Stability and application in yoghurt and soft candy

Coloration Technology, EarlyView.
Abstract The instability of anthocyanins limits their application as natural food colorants. This study aimed to enhance the stability of anthocyanins extracted from Hibiscus sabdariffa through copigmentation with protein nanofibrils produced from pea, rice, gluten and whey isolates. Linear and curly nanofibril structures were prepared and incorporated
Vildan Eyiz, İsmail Tontul, Selman Türker   +2 more
wiley   +1 more source

Effects of low-dose lithium supplementation on thermal inactivation of SERCA in cardiac muscle of male mice. [PDF]

Biosci Rep
Hamstra SI, Geromella MS, Klentrou P, Tiidus PM, MacPherson REK, Fajardo VA.   +5 more
europepmc   +1 more source

Anemia‐associated mutations disrupt the CDIN1‐Codanin1 complex in inherited congenital dyserythropoietic anemia I (CDA‐I) disease

The FEBS Journal, EarlyView.
Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal, Tomas Brom, Ivona Nečasová, Tomáš Janovič, Pavel Veverka, Naina Verma, Lukáš Uhrík, Lenka Hernychova, Ctirad Hofr   +8 more
wiley   +1 more source

Stoichiometrically Defined Antibody-DNA Conjugates for Quantitative Super-Resolution Imaging. [PDF]

Nano Lett
Martinez LP, McMahon C, Zaza C, Dalby OPL, Stack CJ, Baker JR, Chudasama V, Simoncelli S.   +7 more
europepmc   +1 more source

Monomeric CRP and negative acute phase proteins, but not pentameric CRP, as biomarkers of major depression and MDMD. [PDF]

Acta Neuropsychiatr
Almulla AF, Niu M, Stoyanov D, Zhang Y, Maes M.   +4 more
europepmc   +1 more source

Insights into the complexity of SARS-CoV-2 M^pro inhibition: Ebselen and its derivatives impair dimerisation of the enzyme. [PDF]

J Enzyme Inhib Med Chem
Fabbian S, Fabi S, Schwarz L, Preto G, Schiavinato C, Salata C, Crocetti L, Battistutta R, Gatto B, Sosic A.   +9 more
europepmc   +1 more source