An aptamer specifically targeting mCRP ameliorates experimental arthritis [PDF]
Journal of Orthopaedic TranslationBackground: Recent evidence highlights the important role of the liver–bone axis in the development of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The liver secretes various factors that impact joint health, one of which is
Aiping Lu, Chao Liang, Jianmin Guo
exaly +7 more sources
Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]
Journal of Inflammation ResearchAnniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Rafael Fernandez-Botran +2 more
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mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA
Frontiers in Immunology, 2022 BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Yuki Yasuda, Cheng-Long Huang
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The plasma level of mCRP is linked to cardiovascular disease in antineutrophil cytoplasmic antibody-associated vasculitis [PDF]
Arthritis Research and Therapy, 2020 Background C-reactive protein (CRP) has two natural isomers: C-reactive protein pentamer (pCRP) and C-reactive protein monomer (mCRP). The levels of CRP are significantly elevated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ...
Jian Hao, Huang Bin-Tao
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The Binding of Monomeric C-Reactive Protein (mCRP) to Integrins αvβ3 and α4β1 Is Related to Its Pro-Inflammatory Action [PDF]
PLoS ONE, 2014 The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result ...
Yoshikazu Takada +2 more
exaly +6 more sources
Frontiers in Immunology, 2023 ObjectiveThe aim of this study is to explore the prevalence and clinicopathological associations between anti-C1qA08 antibodies and anti-monomeric CRP (mCRP) a.a.35-47 antibodies and to explore the interaction between C1q and mCRP.MethodsNinety patients ...
Ying Tan +2 more
exaly +5 more sources
IgG4-related acute interstitial nephritis and the potential role of mCRP autoantibodies: a case report [PDF]
Renal Failure, 2019 Background: IgG4-related acute tubulointerstitial nephritis is a type of autoimmune-mediated interstitial nephritis. Recently, autoantibodies against modified C-reactive protein (mCRP) were found to play a pathogenic role in renal diseases through the ...
Guisen Li, Lei Pu
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Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?
Frontiers in Immunology, 2023 BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner +14 more
doaj +1 more source
CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm.
PLoS ONE, 2021 ObjectiveThe molecular mechanisms of the degeneration of the aortic wall in abdominal aortic aneurysm (AAA) are poorly understood. The monomeric form of C-reactive protein (mCRP) is deposited in damaged cardiovascular organs and aggravates the prognosis;
Eun Na Kim +9 more
doaj +1 more source
Monomeric CRP regulates inflammatory responses in human intervertebral disc cells
Bone & Joint Research, 2023 Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández +10 more
doaj +1 more source