Results 1 to 10 of about 1,814 (179)

The Binding of Monomeric C-Reactive Protein (mCRP) to Integrins αvβ3 and α4β1 Is Related to Its Pro-Inflammatory Action [PDF]

PLoS ONE, 2014
The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result ...
Yoshikazu Takada, Yoshihiro Izumiya, Yoko K Takada   +2 more
exaly   +8 more sources

Combination of anti-C1qA08 and anti-mCRP a.a.35-47 antibodies is associated with renal prognosis of patients with lupus nephritis [PDF]

Frontiers in Immunology, 2023
ObjectiveThe aim of this study is to explore the prevalence and clinicopathological associations between anti-C1qA08 antibodies and anti-monomeric CRP (mCRP) a.a.35-47 antibodies and to explore the interaction between C1q and mCRP.MethodsNinety patients ...
Ying Tan, Shang-Rong Ji, Ming-Hui Zhao
exaly   +6 more sources

An aptamer specifically targeting mCRP ameliorates experimental arthritis [PDF]

Journal of Orthopaedic Translation
Background: Recent evidence highlights the important role of the liver–bone axis in the development of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The liver secretes various factors that impact joint health, one of which is
Lü Aiping, Chao Liang, Jianmin Guo
exaly   +7 more sources

The plasma level of mCRP is linked to cardiovascular disease in antineutrophil cytoplasmic antibody-associated vasculitis [PDF]

Arthritis Research and Therapy, 2020
Background C-reactive protein (CRP) has two natural isomers: C-reactive protein pentamer (pCRP) and C-reactive protein monomer (mCRP). The levels of CRP are significantly elevated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ...
Jian Hao
exaly   +6 more sources

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]

Journal of Inflammation Research
Anniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C   +9 more
doaj   +4 more sources

IgG4-related acute interstitial nephritis and the potential role of mCRP autoantibodies: a case report [PDF]

Renal Failure, 2019
Background: IgG4-related acute tubulointerstitial nephritis is a type of autoimmune-mediated interstitial nephritis. Recently, autoantibodies against modified C-reactive protein (mCRP) were found to play a pathogenic role in renal diseases through the ...
Guisen Li, Lei Pu
exaly   +4 more sources

Monomeric CRP is prevalent in the blood of patients with rheumatoid arthritis and correlates with clinically relevant markers [PDF]

Frontiers in Immunology
IntroductionElevated C-reactive protein (CRP) is a hallmark of rheumatoid arthritis (RA) flares. CRP exists as pentameric (pCRP) and monomeric (mCRP) isoforms with distinct functions, with pCRP generally pro-inflammatory and mCRP more immunomodulatory ...
Alexia Correia Ferreira, Lucia Martin-Gutierrez, Christophe Lalaurie, Karen Feehan, Priyanka Lakhani, Imogen Buckle, George A. Robinson, Elizabeth C. Jury, Jessica J. Manson, Jessica J. Manson, Thomas C. R. McDonnell   +10 more
doaj   +2 more sources

C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]

Scientific Reports
Choroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez, Sara Romero-Vázquez, Sergio Recalde, Jaione Bezunartea, Maite Moreno Orduña, Idoia Belza-Zuazu, Alfredo García-Layana, Alfredo Adán, Patricia Fernández-Robredo, Blanca Molins   +9 more
doaj   +2 more sources

Higher monomeric C-reactive protein levels are associated with premature coronary artery disease [PDF]

Frontiers in Immunology
IntroductionChronic inflammation is a major risk factor for coronary artery disease (CAD). Currently, the inflammatory cardiovascular risk is assessed via C-reactive protein (CRP) levels measured using a high-sensitivity assay (hsCRP).
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Sergey Okhota, Sergey Okhota, Olga Saburova, Yuliya Avtaeva, Tatiana Kuznetsova, Konstantin Guria, Lyudmila Prokofieva, Tatiana Riazantseva, Tatiana Riazantseva, Shang-Rong Ji, Yi Wu, Zufar Gabbasov   +14 more
doaj   +2 more sources

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]

Frontiers in Immunology
IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar, Víctor Llorenç, Víctor Llorenç, Marc Figueras-Roca, Marc Figueras-Roca, Maite Sainz de-la-Maza, Maite Sainz de-la-Maza, Alfredo Adán, Alfredo Adán, Blanca Molins   +9 more
doaj   +2 more sources