Results 1 to 10 of about 3,242 (179)

An aptamer specifically targeting mCRP ameliorates experimental arthritis [PDF]

Journal of Orthopaedic Translation
Background: Recent evidence highlights the important role of the liver–bone axis in the development of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The liver secretes various factors that impact joint health, one of which is
Zhuqian Wang, Duoli Xie, Peixi Zhu, Jianmin Guo, Chunhao Cao, Yu Du, Aiping Lu, Chao Liang   +7 more
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Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]

Journal of Inflammation Research
Anniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C   +9 more
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mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA

Frontiers in Immunology, 2022
BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Chitose Fujita, Chitose Fujita, Yasuo Sakurai, Yasuo Sakurai, Yuki Yasuda, Rino Homma, Cheng-Long Huang, Cheng-Long Huang, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita   +11 more
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C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]

Scientific Reports
Choroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez, Sara Romero-Vázquez, Sergio Recalde, Jaione Bezunartea, Maite Moreno Orduña, Idoia Belza-Zuazu, Alfredo García-Layana, Alfredo Adán, Patricia Fernández-Robredo, Blanca Molins   +9 more
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Higher monomeric C-reactive protein levels are associated with premature coronary artery disease [PDF]

Frontiers in Immunology
IntroductionChronic inflammation is a major risk factor for coronary artery disease (CAD). Currently, the inflammatory cardiovascular risk is assessed via C-reactive protein (CRP) levels measured using a high-sensitivity assay (hsCRP).
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Sergey Okhota, Sergey Okhota, Olga Saburova, Yuliya Avtaeva, Tatiana Kuznetsova, Konstantin Guria, Lyudmila Prokofieva, Tatiana Riazantseva, Tatiana Riazantseva, Shang-Rong Ji, Yi Wu, Zufar Gabbasov   +14 more
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Monomeric C-reactive protein is associated with severity and prognosis of decompensated hepatitis B cirrhosis [PDF]

Frontiers in Immunology
C-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao, Ping Yuan, Zhao-Ming Tang, Zhao-Ming Tang, Jia-Geng Lei, Ze-Rui Yang, Ze-Rui Yang, Mustafa Ahmed, Mustafa Ahmed, Zhen-Yu Yao, Dan Liang, Dan Liang, Yi Wu, Yi Wu, Hai-Yun Li, Hai-Yun Li   +15 more
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C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]

Frontiers in Immunology
IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar, Víctor Llorenç, Víctor Llorenç, Marc Figueras-Roca, Marc Figueras-Roca, Maite Sainz de-la-Maza, Maite Sainz de-la-Maza, Alfredo Adán, Alfredo Adán, Blanca Molins   +9 more
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C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway [PDF]

Frontiers in Immunology
IntroductionT cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection.
Julia Thomé, Julia Limmer, Julia Limmer, Teresa Z. Brose, Johannes Zeller, Nina Chevalier, Nina Chevalier, Anna-Lena Schäfer, Laura Schneider, Maike Lind, Thierry Christmann, Marie Dreck, Sheena Kreuzaler, David Braig, Karlheinz Peter, Franziska Pankratz, Steffen U. Eisenhardt   +16 more
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A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
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Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
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