Results 41 to 50 of about 1,079 (142)

Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target

Frontiers in Immunology, 2022
Monomeric C-reactive protein (mCRP), once thought to be a figment of the imagination and whose biological activity was ascribed to its sodium azide preservative, has now pronounced itself as a critical molecule playing a direct role in mediating many of ...
Mark Slevin, Mark Slevin, Mark Slevin, Nima Heidari, Nima Heidari, Leonard Azamfirei   +5 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Peripheral vascular function, including endothelium‐dependent measures, and dementia risk: The Framingham Heart Study

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION The relationship between peripheral vascular health, including endothelia, cognitive decline, and Alzheimer's disease (AD) dementia risk is unclear. METHODS In this study, 2844 dementia‐free Framingham Offspring participants (mean age 60.6 years, 53.2% women) had baseline brachial artery flow‐mediated dilation (FMD%) and reactive ...
Qiushan Tao, Jingyan Han, Ting Fang Alvin Ang, Lei Hou, Chunyu Liu, Joanne M. Murabito, Kathryn L. Lunetta, Jesse Mez, Michael L. Alosco, Thor D. Stein, Xiaoling Zhang, Rhoda Au, Lindsay Farrer, Joseph N. Palmisano, Naomi M. Hamburg, Wei Qiao Qiu   +15 more
wiley   +1 more source

A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects

Frontiers in Immunology, 2023
C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically,
Margaret E. Olson, Mary G. Hornick, Ashley Stefanski, Haya R. Albanna, Alesia Gjoni, Griffin D. Hall, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa   +8 more
doaj   +1 more source

A Base‐Free Two‐Coordinate Oxoborane

Angewandte Chemie, Volume 137, Issue 7, February 10, 2025.
A base‐free, two coordinate oxoborane (R‐BO) has been isolated as a Lewis adduct with AlCl3 and shown to react in a unique way with PhN3. In contrast to the parent oxoborane, the oxoborane→AlCl3 adduct is stable towards oligomerisation and C−H cleavage of the Mes* group as AlCl3 coordination provides thermodynamic stabilization while also reducing the ...
Clement R. P. Millet, Dominic R. Willcox, Gary S. Nichol, Cate S. Anstöter, Michael J. Ingleson   +4 more
wiley   +2 more sources

C reactive protein elevation among children or among mothers’ of children with autism during pregnancy, a review and meta-analysis

BMC Psychiatry, 2020
Objective To evaluate if children with ASD, or mothers of ASD children have elevated CRP during pregnancy. Background Autism spectrum disorder (ASD) is a neuro developmental disorder with incidence of 1 in 68 children occur in all racial, ethnic, and ...
Rashid Nadeem, Tamseela Hussain, Hassan Sajid   +2 more
doaj   +1 more source

Using Risk–Benefit Analysis and the Analytical Hierarchy Process to Decide on the Implementation of Rapid Salmonella Detection Methods in Large Poultry Industries

Risk Analysis, Volume 46, Issue 4, April 2026.
ABSTRACT Tools based on multi‐criteria decision analysis (MCDA) can be used in decision‐making processes related to food safety issues (FSI). We used risk–benefit analysis (RBA) and the analytic hierarchy process (AHP) to answer the following questions: What are the benefits and risks of using rapid Salmonella assays in large‐scale poultry industries ...
Cris Rocha Pinto Magalhães, Nathanyelle Soraya Martins de Aquino, Eduardo Cesar Tondo   +2 more
wiley   +1 more source

In vitro generation and bioactivity evaluation of C-reactive protein intermediate. [PDF]

PLoS ONE, 2018
The conformational conversion of pentameric C-reactive protein (pCRP) to monomeric CRP (mCRP) has been shown to play important roles in the action of CRP in inflammation regulation.
Jian-Min Lv, Ming-Yu Wang
doaj   +1 more source

Prospective validation of podoplanin expression as a diagnostic biomarker of acute promyelocytic leukemia

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 2, Page 128-133, March 2026.
Abstract Acute promyelocytic leukemia (APL) is a medical emergency that needs immediate diagnosis and treatment. Podoplanin, a transmembrane glycoprotein that binds CLEC‐2 on platelets, was recently demonstrated to be abnormally expressed in leukemic blasts in APL, as opposed to other forms of AML, in a study using thawed primary cells.
Camilla Maria de Alencar Saraiva, Carla Roberta Peachazepi Moraes, Bruno Kosa Lino Duarte, Gislaine Borba Oliveira, Herton Luiz Alves Sales Filho, Paula de Melo Campos, Sara Teresinha Olalla Saad, Erich Vinicius De Paula   +7 more
wiley   +1 more source

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source