Results 41 to 50 of about 1,814 (179)

Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction Human study shows that elevated C‐reactive protein (CRP) in blood impacts apolipoprotein E (APOE) ε4, but not APOE ε3 or APOE ε2, genotype to increase the risk of Alzheimer's disease (AD).
Qini Gan, Alfred Wong, Zhengrong Zhang, Hana Na, Hua Tian, Qiushan Tao, Ibraheem M. Rajab, Lawrence A. Potempa, Wei Qiao Qiu   +8 more
doaj   +1 more source

Monomeric C-reactive protein is associated with severity and prognosis of decompensated hepatitis B cirrhosis

Frontiers in Immunology
C-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao, Ping Yuan, Zhao-Ming Tang, Zhao-Ming Tang, Jia-Geng Lei, Ze-Rui Yang, Ze-Rui Yang, Mustafa Ahmed, Mustafa Ahmed, Zhen-Yu Yao, Dan Liang, Dan Liang, Yi Wu, Yi Wu, Hai-Yun Li, Hai-Yun Li   +15 more
doaj   +1 more source

The Pathogenic Role of C-Reactive Protein in Diabetes-Linked Unstable Atherosclerosis. [PDF]

Int J Mol Sci
C-reactive protein (CRP) has long been recognized as a biomarker of systemic inflammation and cardiovascular disease (CVD) risk. However, emerging evidence highlights the distinct and potent pro-inflammatory role of its monomeric form (mCRP), which is ...
Sibianu M, Slevin M.
europepmc   +2 more sources

Monomeric C-reactive protein-a key molecule driving development of Alzheimer's disease associated with brain ischaemia? [PDF]

, 2015
Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, associating with microvasculature, neurons and AD-plaques, Aβ, also, being able to
Popa-Wagner, A, Weston, R., Potempa, LA, Revilla, S, Krupinski, J, Corpas, Rubén, Krupinski, J., Font, M.A., Sarroca, S., Boras, E., Boras, E, Petcu, E., Slevin, M, Di Napoli, M, Sanfeliu, C, Matou, S, Potempa, L.A., Sanfeliu, C., Al-Baradie, Raid, Petcu, E, Badimon, Lina, Di Napoli, M., Liu, Daijun, Al-baradie, R, Corpas, R, Zeinolabediny, Y, Badimon, L, Revilla, Susana, Font, MA, Popa-Wagner, A., Love, S., Slevin, Mark, Sarroca, S, Liu, D, Weston, R, Slevin, M., Universitat Autònoma de Barcelona, Matou, S., Zeinolabediny, Yasmin, Love, S, Sarroca, Sara, Krupinski, Jerzy, Sanfeliu, Coral, Font, M.ª Angels, Badimón Maestro, Lina   +44 more
core   +2 more sources

An ELISA Assay for Quantifying Monomeric C-Reactive Protein in Plasma

Frontiers in Immunology, 2018
Native C-reactive protein (nCRP) is a non-specific marker of inflammation being claimed as a bystander in several chronic disorders. Accumulating evidence indicates that nCRP dissociates to and acts primarily as the monomeric conformation (mCRP) at ...
Lin Zhang, Hai-Yun Li, Wei Li, Zhi-Yuan Shen, Yin-Di Wang, Shang-Rong Ji, Yi Wu   +6 more
doaj   +1 more source

Role of Ischemic Preconditioning in the Cardioprotective Mechanisms of Monomeric C-Reactive Protein-Deposited Myocardium in a Rat Model

Journal of Chest Surgery, 2021
Background: The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI.
Eun Na Kim, Jae-Sung Choi, Chong Jai Kim, So Ra Kim, Se Jin Oh   +4 more
doaj   +1 more source

Docking simulation predicts that mCRP binds to integrin αvβ3 but pCRP does not.

, 2014
a) The headpiece of integrin αvβ3 (PDB code 1LG5) was used as a target. The docking model predicts that mCRP (red) binds to the RGD-binding site of the integrin αvβ3 headpiece (green and blue). Amino acid residues involved in αvβ3-mCRP interaction are in
Yoko K. Takada (365353), Yoshikazu Takada (32897), Yoshihiro Izumiya (449433), Masaaki Fujita (365351)   +3 more
core   +1 more source

A novel diagnostic mCRP ALISA assay for the detection of chronic inflammation diseases

, 2021
An elevated C-reactive protein (CRP) level in plasma has long been used in clinical practice as a significant risk predictor for inflammatory diseases such as cardiovascular diseases.
MUNUSWAMY, Revathy
core   +1 more source

The Cholesterol-Binding Sequence in Monomeric C-Reactive Protein Binds to the SARS-CoV-2 Spike Receptor-Binding Domain and Blocks Interaction With Angiotensin-Converting Enzyme 2

Frontiers in Immunology, 2022
The receptor-binding domain (RBD) of the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to the human angiotensin-converting enzyme 2 (ACE2) receptor, which is a prerequisite for the virus to enter the cell. C-reactive
Hai-yun Li, Hai-yun Li, Ning Gao, Cheng-yang Liu, Xiao-ling Liu, Feng Wu, Nini Dai, Jing Han, Jing Han, Qiu-yu Li   +9 more
doaj   +1 more source

MCRP Community Planning Graduate Studio 2005/06: King City Community Plan

Focus, 2006
During the current academic year, the City and Regional Planning Department graduate Community Planning Studio is engaged in important community-outreach that will make a difference in King City CA. Nuworsoo and Topping, the class instructors, resume the studio's pedagogy and do a brief discussion of the process and progress of this year's work in King
Nuworsoo, Cornelius, Topping, Kenneth
openaire   +3 more sources