The XGBoost Model Versus the Logistic Regression Model Created Based on Serum Markers in Predicting the Risk of Post-Stroke Cognitive Impairment Following Acute Ischemic Stroke. [PDF]
Brain BehavFrom 261 acute ischemic stroke patients (training n = 183, testing n = 78), we collected demographic data, cognitive assessments, and serum indicators. LassoCV identified sensitive predictors including VE‐Cad, NIHSS score, CRP, age, drinking history, education years.
Yang X +5 more
europepmc +2 more sources
Role of ischemic preconditioning in cardioprotective mechanisms of mCRP deposited myocardium in a rat model [PDF]
, 2020 Abstract The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. We evaluated the effects of IPC on mCRP-deposited myocardium due to IRI in a rat model. Myocardial IRI was
Kim, Eun Na +5 more
openaire +1 more source
Image_1_mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA.tif
, 2022 BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Rino Homma (12985229) +5 more
core +1 more source
Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathology [PDF]
, 2021 Abstract BACKGROUND C-reactive protein (CRP) in peripheral inflammation is associated with increased Alzheimer’s disease (AD) risk in Apolipoprotein E4 (ApoE4), but not ApoE3 or E2, humans. It remains unknown whether peripheral monomeric CRP (mCRP) induces AD pathogenesis through some receptor of ...
Zhengrong Zhang +18 more
openaire +1 more source
Serum C-reactive protein is an important and powerful prognostic biomarker in most adult solid tumors. [PDF]
PLoS ONE, 2018 INTRODUCTION:Prognostication in cancer is challenging and inaccurate. C-Reactive Protein (CRP), a cheap and sensitive marker of inflammation may help. This study investigated the relationship between CRP and prognosis in a large cohort of solid tumors ...
Shiva Shrotriya +9 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a large production of autoantibodies and deficient clearance of cellular waste.
Jesper Karlsson +5 more
doaj +1 more source
C-Reactive Protein in Atherosclerosis—More than a Biomarker, but not Just a Culprit
Reviews in Cardiovascular Medicine, 2023 C-reactive protein (CRP) is a pentraxin that is mainly synthesized in the liver in response to inflammatory cytokines. It exists in two functionally and structurally distinct isoforms.
Kürsat Kirkgöz
doaj +1 more source
Representative CRP and mCRP immunostaining according to serum CRP levels.
, 2021 (A) Low serum CRP (≤0.1 mg/dL). (B) High serum CRP (1.39 mg/dL) (anti-CRP antibody, anti-mCRP antibody, × 40).
Chong Jai Kim (8828177) +9 more
core +1 more source
Monomeric C‐reactive protein induces the cellular pathology of Alzheimer's disease
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Human study shows that elevated C‐reactive protein (CRP) in blood impacts apolipoprotein E (APOE) ε4, but not APOE ε3 or APOE ε2, genotype to increase the risk of Alzheimer's disease (AD).
Qini Gan +8 more
doaj +1 more source
Frontiers in ImmunologyC-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao +15 more
doaj +1 more source