Monomeric C-Reactive Protein Aggravates Secondary Degeneration after Intracerebral Haemorrhagic Stroke and May Function as a Sensor for Systemic Inflammation [PDF]
Journal of Clinical Medicine, 2020 BACKGROUND:We previously identified increased tissue localization of monomeric C-reactive protein (mCRP) in the infarcted cortical brain tissue of patients following ischaemic stroke.
Mark Slevin +2 more
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C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]
Frontiers in ImmunologyIntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar +9 more
doaj +2 more sources
Role of C-Reactive Protein at Sites of Inflammation and Infection
Frontiers in Immunology, 2018 C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ...
Nicola R. Sproston, Jason J. Ashworth
doaj +2 more sources
AntioxidantsResveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol against the proinflammatory monomeric C-reactive protein (mCRP).
Clara Bartra +8 more
doaj +2 more sources
C-reactive protein: the nexus between inflammation and protein misfolding diseases. [PDF]
Front ImmunolC-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Roy A +7 more
europepmc +2 more sources
Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator. [PDF]
Front ImmunolMost early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Potempa M +3 more
europepmc +2 more sources
C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway [PDF]
Frontiers in ImmunologyIntroductionT cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection.
Julia Thomé +16 more
doaj +2 more sources
An ELISA Assay for Quantifying Monomeric C-Reactive Protein in Plasma
Frontiers in Immunology, 2018 Native C-reactive protein (nCRP) is a non-specific marker of inflammation being claimed as a bystander in several chronic disorders. Accumulating evidence indicates that nCRP dissociates to and acts primarily as the monomeric conformation (mCRP) at ...
Lin Zhang +6 more
doaj +2 more sources
Microglial pro-inflammatory mechanisms induced by monomeric C-reactive protein are counteracted by soluble epoxide hydrolase inhibitors. [PDF]
Int ImmunopharmacolMonomeric C-reactive protein (mCRP) is a pro-inflammatory molecule generated by the dissociation of native CRP. Clinical and experimental studies suggest that mCRP deposition in the brain induces Alzheimer’s disease (AD) pathology and cognitive loss ...
Bartra C +15 more
europepmc +2 more sources
Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons
Journal of Inflammation Research, 2021 Revathy Munuswamy,1,* Jana De Brandt,2,* Chris Burtin,2 Wim Derave,3 Joseph Aumann,4 Martijn A Spruit,5,6,* Luc Michiels1,* 1Faculty of Medicine and Life Sciences, Biomedical Research Institute BIOMED, Hasselt University, Hasselt, Belgium;
Munuswamy R +6 more
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