Results 51 to 60 of about 1,780 (172)

Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract Vascular cognitive impairment (VCI), the second leading cause of dementia, is characterized by heterogeneous pathophysiology and a potentially reversible early phase, underscoring the need for timely identification. This review synthesizes advances across four complementary domains – targeted cognitive assessments, imaging biomarkers ...
Wenqi Song, Xiaoqun Liu, Tianrui Yu, Yuanyuan Xiang, Peijie Fu, Moxin Wu, Xiaoping Yin, Xiaorong Zhang, Zhiying Chen   +8 more
wiley   +1 more source

Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells

Biomolecules & Biomedicine, 2020
C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the ...
Yong Zhang, Hongxia Cao
doaj   +1 more source

Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target

Frontiers in Immunology, 2022
Monomeric C-reactive protein (mCRP), once thought to be a figment of the imagination and whose biological activity was ascribed to its sodium azide preservative, has now pronounced itself as a critical molecule playing a direct role in mediating many of ...
Mark Slevin, Mark Slevin, Mark Slevin, Nima Heidari, Nima Heidari, Leonard Azamfirei   +5 more
doaj   +1 more source

Docking simulation predicts that mCRP binds to integrin αvβ3 but pCRP does not.

, 2014
a) The headpiece of integrin αvβ3 (PDB code 1LG5) was used as a target. The docking model predicts that mCRP (red) binds to the RGD-binding site of the integrin αvβ3 headpiece (green and blue). Amino acid residues involved in αvβ3-mCRP interaction are in
Yoko K. Takada (365353), Yoshikazu Takada (32897), Yoshihiro Izumiya (449433), Masaaki Fujita (365351)   +3 more
core   +1 more source

Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on

Acta Ophthalmologica, Volume 104, Issue 4, Page e443-e452, June 2026.
Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse, Anne Sina Paula Simon, Viera Kalinina Ayuso, Joke Helena de Boer, Gerrit van den Berg   +4 more
wiley   +1 more source

mCRP, and less efficiently pCRP, specifically bind to α4β1.

, 2014
a). Adhesion of α4-CHO cells to CRP isoforms. Wells of 96 well microtiter plate were coated with mCRP or pCRP and remaining protein-binding sites were blocked with BSA.
Yoko K. Takada (365353), Yoshikazu Takada (32897), Yoshihiro Izumiya (449433), Masaaki Fujita (365351)   +3 more
core   +1 more source

A biofunctional review of C-reactive protein (CRP) as a mediator of inflammatory and immune responses: differentiating pentameric and modified CRP isoform effects

Frontiers in Immunology, 2023
C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically,
Margaret E. Olson, Mary G. Hornick, Ashley Stefanski, Haya R. Albanna, Alesia Gjoni, Griffin D. Hall, Peter C. Hart, Ibraheem M. Rajab, Lawrence A. Potempa   +8 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Amino acid residues involved in mCRP-αvβ3 interaction.

, 2014
Amino acid residues in integrin αvβ3 and mCRP within 6 Å to each other in the docking model were identified using Swiss-pdb viewer v. 4.1.
Yoko K. Takada (365353), Yoshikazu Takada (32897), Yoshihiro Izumiya (449433), Masaaki Fujita (365351)   +3 more
core   +1 more source

Monomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia? [PDF]

, 2015
Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, associating with microvasculature, neurons and AD-plaques, Aβ, also, being able to
Liu, R., Popa-Wagner, A, Weston, R., Potempa, LA, Revilla, S, Krupinski, J, Corpas, Rubén, Krupinski, J., Font, M. A., Al-baradie, R., Font, M.A., Sarroca, S., Boras, E., Petcu, Eugen, Boras, E, Petcu, E., Slevin, M, Di Napoli, M, Sanfeliu, C, Matou, S, Potempa, L.A., Sanfeliu, C., Badimon, L., Al-Baradie, Raid, Petcu, E, Badimon, Lina, Di Napoli, M., Potempa, L. A., Liu, Daijun, Zeinolabediny, Y., Al-baradie, R, Corpas, R, Corpas, R., Zeinolabediny, Y, Badimon, L, Revilla, Susana, Font, MA, Popa-Wagner, A., Love, S., Slevin, Mark, Revilla, S., Sarroca, S, Liu, D, Weston, R, Slevin, M., Universitat Autònoma de Barcelona, Matou, S., Zeinolabediny, Yasmin, Love, S   +48 more
core   +2 more sources