Results 71 to 80 of about 1,780 (172)

Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions

MedComm, Volume 7, Issue 3, March 2026.
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu, Rou Xue, Xiangwen Luo, Jiangnan Liao, Zongbo Zhang, Jinhai Deng, Teng Liu, Xin Li, Zhe‐Sheng Chen, Mingzhu Yin   +9 more
wiley   +1 more source

Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease

MedComm, Volume 7, Issue 3, March 2026.
CD31 upregulation in 5xFAD mice activates STAT1/Irf1 signaling, driving abnormal gene transcription, Aβ and tau accumulation, microglial activation, and neuroinflammation, leading to cognitive decline. Systemic CD31 knockdown suppresses STAT1/Irf1 activity, restores gene expression balance, reduces Aβ and tau pathologies, alleviates neuroinflammation ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Xiuping Liu, Ying Yang, Dan Ke, Xiao‐Chuan Wang, Enjie Liu, Jian‐Zhi Wang   +17 more
wiley   +1 more source

Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway

Journal of Inflammation Research, 2021
Zhimin Zha,1,* Yujia Cheng,2,3,* Lu Cao,2 Yanxia Qian,2 Xinjian Liu,3,4 Yan Guo,1 Junhong Wang2 1Department of Gerontology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of ...
Zha Z, Cheng Y, Cao L, Qian Y, Liu X, Guo Y, Wang J   +6 more
doaj  

Impact of Endodontic Treatment of Teeth With Apical Periodontitis on Levels of Inflammatory Biomarkers Associated With Cardiovascular Risk: A Systematic Review and Meta‐Analysis

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Background Apical periodontitis (AP) is an inflammatory response to microbial infection of the root canal system. The microorganisms that cause AP can modulate the host’s immune response by secreting inflammatory biomarkers, which might be associated with cardiovascular diseases.
Carolina Viana Vasco Lyra, Jéssica Meirinhos Miranda, Renata de Albuquerque Cavalcanti Almeida, Marina da Cunha Isaltino, Ana Virginia Silva Vilela, Marleny Elizabeth Márquez de Martínez Gerbi, Diana Santana de Albuquerque, Natália Gomes de Oliveira, Dariusz Chlubek   +8 more
wiley   +1 more source

A Review of Anti-C Reactive Protein Antibodies in Systemic Lupus Erythematosus

Journal of Interdisciplinary Medicine, 2021
Systemic lupus erythematosus (SLE), the prototype autoimmune disease, is characterized by the production of a plethora of autoantibodies with various roles in the development of disease-related tissue damage.
Richter Patricia, Burlui Alexandra, Bratoiu Ioana, Cardoneanu Anca, Rezus Ciprian, Rezus Elena   +5 more
doaj   +1 more source

Influence of Acute Phase Proteins on Neutrophil Function In Vitro

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
Acute phase proteins (APPs) modulate neutrophil granulocyte (PMN) functions in a concentration‐dependent manner. While CRP showed minimal activation, ferritin altered the oxidative burst, and fibrinogen mainly affected surface marker expression. These moderate but distinct effects highlight the relevance of APP–PMN interactions in inflammation and ...
Richard F. Kraus, Isabell Wild, Michael A. Gruber, Martin G. Kees   +3 more
wiley   +1 more source

Endocrine Implications of Thyroid Incidentalomas Detected During Lymphoma Staging With 18F‐Fluorodeoxyglucose Positron Emission Tomography

Clinical Endocrinology, Volume 103, Issue 4, Page 605-611, October 2025.
ABSTRACT Objective This study investigated the prevalence, characteristics, and endocrine implications of thyroid incidentalomas detected during lymphoma staging using FDG‐PET/CT. Design Retrospective cohort study. Patients A total of 795 adult patients with lymphoma who underwent FDG‐PET/CT for staging at a tertiary oncology centre were included ...
Marcos Tadashi Kakitani Toyoshima, Roberta Morgado Ferreira Zuppani, Isabelle Pinheiro Amaro, Camila Regina Pereira Batista de Macedo, Ricardo Miguel Costa de Freitas, Rodrigo Dolphini Velasques, Juliana Pereira, Rafael Loch Batista, Debora Lúcia Seguro Danilovic, Delmar Muniz Lourenço Jr., Ana O. Hoff   +10 more
wiley   +1 more source

The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages

Frontiers in Immunology, 2018
Inflammation is regulated by many endogenous factors including estrogen, a steroid hormone that declines with increasing age, leading to excessive inflammation in the elderly. C-reactive protein (CRP) is an acute phase inflammatory protein that exists in
Nicola R. Sproston, Mohamed El Mohtadi, Mark Slevin, William Gilmore, Jason J. Ashworth   +4 more
doaj   +1 more source

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 3, Page 765-815, September 2025.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S. Hudson, Séamus Hussey, Johan van Limbergen, Erasmo Miele, Lorenzo Norsa, Ola Olén, Gianluca Pellino, Patrick van Rheenen, Lissy de Ridder, Richard K. Russell, Dror S. Shouval, Eunice Trindade, Dan Turner, David C. Wilson, Anat Yerushalmy Feler, Amit Assa   +24 more
wiley   +1 more source

The Benefits of Licensed Midwifery and Community Birth Among BIPOC Birthing People in New Mexico

Birth, Volume 52, Issue 2, Page 285-290, June 2025.
Black, Indigenous, and people of color (BIPOC) families comprise a disproportionately low percentage of home and freestanding birth center births in New Mexico, despite NM Medicaid coverage of care by Licensed Midwives (LMs) in these settings. The purpose of this study was to examine why low income BIPOC seek out LM care, how they benefit from this ...
Raquel Z. Rivera, Micaela Lara Cadena, Jess F. Gutfreund, Esperanza Dodge   +3 more
wiley   +1 more source