Results 81 to 90 of about 2,036 (174)

Downregulating Platelet Endothelial Cell Adhesion Molecule‐1 Enhances Learning and Memory and Alleviates Hallmark Pathologies in Alzheimer's Disease

MedComm, Volume 7, Issue 3, March 2026.
CD31 upregulation in 5xFAD mice activates STAT1/Irf1 signaling, driving abnormal gene transcription, Aβ and tau accumulation, microglial activation, and neuroinflammation, leading to cognitive decline. Systemic CD31 knockdown suppresses STAT1/Irf1 activity, restores gene expression balance, reduces Aβ and tau pathologies, alleviates neuroinflammation ...
Qiuzhi Zhou, Fei Sun, Yao Zhang, Xiaojian Cao, Mengzhu Li, Haitao Yu, Tao Jiang, Shihong Li, Weixia Wang, Jiazhao Xie, Ting He, Yanchao Liu, Xiuping Liu, Ying Yang, Dan Ke, Xiao‐Chuan Wang, Enjie Liu, Jian‐Zhi Wang   +17 more
wiley   +1 more source

CRP Is Transported by Monocytes and Monocyte-Derived Exosomes in the Blood of Patients with Coronary Artery Disease

Biomedicines, 2020
The objective of this work was to study the ability of blood cells and their microparticles to transport monomeric and pentameric forms of C-reactive protein (mCRP and pCRP) in the blood of patients with coronary artery disease (CAD).
Ivan Melnikov, Sergey Kozlov, Olga Saburova, Ekaterina Zubkova, Olga Guseva, Sergey Domogatsky, Tatiana Arefieva, Natalia Radyukhina, Maria Zvereva, Yuliya Avtaeva, Lyudmila Buryachkovskaya, Zufar Gabbasov   +11 more
doaj   +1 more source

Monomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia? [PDF]

, 2015
Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, associating with microvasculature, neurons and AD-plaques, Aβ, also, being able to
Liu, R., Popa-Wagner, A, Weston, R., Potempa, LA, Revilla, S, Krupinski, J, Corpas, Rubén, Krupinski, J., Font, M. A., Al-baradie, R., Font, M.A., Sarroca, S., Boras, E., Petcu, Eugen, Boras, E, Petcu, E., Slevin, M, Di Napoli, M, Sanfeliu, C, Matou, S, Potempa, L.A., Sanfeliu, C., Badimon, L., Al-Baradie, Raid, Petcu, E, Badimon, Lina, Di Napoli, M., Potempa, L. A., Liu, Daijun, Zeinolabediny, Y., Al-baradie, R, Corpas, R, Corpas, R., Zeinolabediny, Y, Badimon, L, Revilla, Susana, Font, MA, Popa-Wagner, A., Love, S., Slevin, Mark, Revilla, S., Sarroca, S, Liu, D, Weston, R, Slevin, M., Universitat Autònoma de Barcelona, Matou, S., Zeinolabediny, Yasmin, Love, S   +48 more
core   +1 more source

Impact of Endodontic Treatment of Teeth With Apical Periodontitis on Levels of Inflammatory Biomarkers Associated With Cardiovascular Risk: A Systematic Review and Meta‐Analysis

The Scientific World Journal, Volume 2026, Issue 1, 2026.
Background Apical periodontitis (AP) is an inflammatory response to microbial infection of the root canal system. The microorganisms that cause AP can modulate the host’s immune response by secreting inflammatory biomarkers, which might be associated with cardiovascular diseases.
Carolina Viana Vasco Lyra, Jéssica Meirinhos Miranda, Renata de Albuquerque Cavalcanti Almeida, Marina da Cunha Isaltino, Ana Virginia Silva Vilela, Marleny Elizabeth Márquez de Martínez Gerbi, Diana Santana de Albuquerque, Natália Gomes de Oliveira, Dariusz Chlubek   +8 more
wiley   +1 more source

C-Reactive Protein and Cancer: Interpreting the Differential Bioactivities of Its Pentameric and Monomeric, Modified Isoforms

Frontiers in Immunology, 2021
C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Lawrence A. Potempa, Ibraheem M. Rajab, Margaret E. Olson, Peter C. Hart   +3 more
doaj   +1 more source

Influence of Acute Phase Proteins on Neutrophil Function In Vitro

FASEB BioAdvances, Volume 7, Issue 10, October 2025.
Acute phase proteins (APPs) modulate neutrophil granulocyte (PMN) functions in a concentration‐dependent manner. While CRP showed minimal activation, ferritin altered the oxidative burst, and fibrinogen mainly affected surface marker expression. These moderate but distinct effects highlight the relevance of APP–PMN interactions in inflammation and ...
Richard F. Kraus, Isabell Wild, Michael A. Gruber, Martin G. Kees   +3 more
wiley   +1 more source

Endocrine Implications of Thyroid Incidentalomas Detected During Lymphoma Staging With 18F‐Fluorodeoxyglucose Positron Emission Tomography

Clinical Endocrinology, Volume 103, Issue 4, Page 605-611, October 2025.
ABSTRACT Objective This study investigated the prevalence, characteristics, and endocrine implications of thyroid incidentalomas detected during lymphoma staging using FDG‐PET/CT. Design Retrospective cohort study. Patients A total of 795 adult patients with lymphoma who underwent FDG‐PET/CT for staging at a tertiary oncology centre were included ...
Marcos Tadashi Kakitani Toyoshima, Roberta Morgado Ferreira Zuppani, Isabelle Pinheiro Amaro, Camila Regina Pereira Batista de Macedo, Ricardo Miguel Costa de Freitas, Rodrigo Dolphini Velasques, Juliana Pereira, Rafael Loch Batista, Debora Lúcia Seguro Danilovic, Delmar Muniz Lourenço Jr., Ana O. Hoff   +10 more
wiley   +1 more source

Monomeric CRP Aggravates Myocardial Injury After Myocardial Infarction by Polarizing the Macrophage to Pro-Inflammatory Phenotype Through JNK Signaling Pathway

Journal of Inflammation Research, 2021
Zhimin Zha,1,* Yujia Cheng,2,3,* Lu Cao,2 Yanxia Qian,2 Xinjian Liu,3,4 Yan Guo,1 Junhong Wang2 1Department of Gerontology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of ...
Zha Z, Cheng Y, Cao L, Qian Y, Liu X, Guo Y, Wang J   +6 more
doaj  

Table_1_Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?.docx

, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Kristina Bang Christensen (7615628), Patricia Switten Nielsen (11358321), Torben Steiniche (5350943), Christian Kersten (9215), Helle Zibrandtsen (14805979), Jeanette Baehr Georgsen (11358324), Erik Thorlund Parner (9446178), Anne Helene Køstner (11358318), Ibraheem M. Rajab (11388143), Lawrence A. Potempa (11388140), Anniken Jørlo Fuglestad (14805976)   +10 more
core   +1 more source

Management of paediatric ulcerative colitis, part 1: Ambulatory care—An updated evidence‐based consensus guideline from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition and the European Crohn's and Colitis Organisation

Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 3, Page 765-815, September 2025.
Abstract Objectives Despite advances in the management of ambulatory paediatric ulcerative colitis (UC), challenges remain as many patients are refractory to therapy and some require colectomy. The aim of these guidelines is to provide an update on optimal care for UC through detailed recommendations and practice points. Methods These guidelines are an
Eytan Wine, Marina Aloi, Stephanie Van Biervliet, Jiri Bronsky, Javier Martín di Carpi, Marco Gasparetto, Laura Gianolio, Hannah Gordon, Iva Hojsak, Alexandra S. Hudson, Séamus Hussey, Johan van Limbergen, Erasmo Miele, Lorenzo Norsa, Ola Olén, Gianluca Pellino, Patrick van Rheenen, Lissy de Ridder, Richard K. Russell, Dror S. Shouval, Eunice Trindade, Dan Turner, David C. Wilson, Anat Yerushalmy Feler, Amit Assa   +24 more
wiley   +1 more source