C-reactive protein isoforms as prognostic markers of COVID-19 severity [PDF]
Frontiers in Immunology, 2023 C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Alfredo Adán +2 more
exaly +6 more sources
Monomeric CRP is prevalent in the blood of patients with rheumatoid arthritis and correlates with clinically relevant markers [PDF]
Frontiers in ImmunologyIntroductionElevated C-reactive protein (CRP) is a hallmark of rheumatoid arthritis (RA) flares. CRP exists as pentameric (pCRP) and monomeric (mCRP) isoforms with distinct functions, with pCRP generally pro-inflammatory and mCRP more immunomodulatory ...
Alexia Correia Ferreira +10 more
doaj +3 more sources
Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?
Frontiers in Immunology, 2023 BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Torben Steiniche +2 more
exaly +4 more sources
Human Fcγ-receptors selectively respond to C-reactive protein isoforms
Frontiers in ImmunologyIntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ ...
Philipp Kolb +2 more
exaly +4 more sources
C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]
Scientific ReportsChoroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez +9 more
doaj +3 more sources
Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity [PDF]
Current Issues in Molecular BiologyC-reactive protein (CRP) is a well-known acute phase reactant and putative biomarker for advancing and chronically established inflammation. Its biological activity across its multiple isoforms plays various roles in the initiation, potentiation, and ...
Alison Gerhardt +15 more
doaj +3 more sources
AGEs–RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition [PDF]
AntioxidantsBackground. Chronic kidney disease [CKD] is characterized by increased glycoxidative stress, inflammation, and mitochondrial dysfunction. Advanced glycation end-products [AGEs] and their receptor [RAGE] mediate glycoxidative stress, whereas mitochondrial-
Mohamed E. Suliman +6 more
doaj +3 more sources
In vitro effects of azide-containing human CRP isoforms and oxLDL on U937-derived macrophage production of atherosclerosis-related cytokines. [PDF]
Exp Ther Med, 2020 Atherosclerosis is an inflammatory chronic disease of the arterial wall. Monomeric (m) and pentameric (p) C-reactive protein (CRP) and oxidized low density lipoproteins (oxLDL) seem to affect the pattern of cytokine production by macrophages, thus ...
Jundi D, Krayem I, Bazzi S, Karam M.
europepmc +2 more sources
Frontiers in Immunology, 2023 C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically,
Margaret E. Olson +8 more
doaj +2 more sources
Journal of Autoimmunity, 2023 The pentraxin C-reactive protein (CRP) is a pentameric protein now known to be able to undergo dissociation into a monomeric, modified isoform, referred to as mCRP.
Rafael Fernandez-botran +2 more
exaly +2 more sources