Results 1 to 10 of about 10,390 (133)
Frontiers in Immunology, 2023 C-reactive protein (CRP) is an acute phase, predominantly hepatically synthesized protein, secreted in response to cytokine signaling at sites of tissue injury or infection with the physiological function of acute pro-inflammatory response. Historically,
Peter Hart +2 more
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The combination of CRP isoforms with oxLDL decreases TNF-α and IL-6 release by U937-derived macrophages [PDF]
Biomedical Reports, 2017 C-reactive protein (CRP) and oxidized low density lipoprotein (oxLDL) serve major roles at both early and advanced stages of atherosclerosis. CRP exists in two isoforms, monomeric (m) and pentameric (p), that bring about pro- or anti-inflammatory effects in macrophages.
Samer Bazzi
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Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?
Frontiers in Immunology, 2023 BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Torben Steiniche +2 more
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Frontiers in Immunology, 2023 The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome ...
Larsson Marie +2 more
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Human Fcγ-receptors selectively respond to C-reactive protein isoforms [PDF]
Frontiers in ImmunologyIntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ ...
Anna Henning +10 more
doaj +2 more sources
C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]
Scientific ReportsChoroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez +9 more
doaj +2 more sources
C-reactive protein isoforms as prognostic markers of COVID-19 severity
Frontiers in Immunology, 2023 C-reactive protein (CRP), an active regulator of the innate immune system, has been related to COVID-19 severity. CRP is a dynamic protein undergoing conformational changes upon activation in inflammatory microenvironments between pentameric and ...
Marc Figueras-Roca +2 more
exaly +3 more sources
Frontiers in Immunology, 2021 C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Peter Hart +2 more
exaly +3 more sources
In vitro effects of azide-containing human CRP isoforms and oxLDL on U937-derived macrophage production of atherosclerosis-related cytokines. [PDF]
Exp Ther Med, 2020 Jundi D, Krayem I, Bazzi S, Karam M.
europepmc +3 more sources
Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity [PDF]
Current Issues in Molecular BiologyC-reactive protein (CRP) is a well-known acute phase reactant and putative biomarker for advancing and chronically established inflammation. Its biological activity across its multiple isoforms plays various roles in the initiation, potentiation, and ...
Alison Gerhardt +15 more
doaj +2 more sources