Results 41 to 50 of about 10,390 (133)
Arthritis &Rheumatology, Accepted Article.Objective To investigate the prevalence and longitudinal evolution of anti‐carbamylated fibrinogen antibodies (ACa‐Fib) of IgG and IgA isotypes in early rheumatoid arthritis (RA), and determine whether these antibodies provide additional diagnostic and prognostic information beyond anti‐cyclic citrullinated peptide antibodies (anti‐CCP) and rheumatoid ...
Pauline Brevet +11 more
wiley +1 more source
The effect of immunomodulatory drugs on aortic stenosis: a Mendelian randomisation analysis
Scientific Reports, 2023 There are currently no approved pharmacological treatment options for aortic stenosis (AS), and there are limited identified drug targets for this chronic condition.
Jonathan L. Ciofani +7 more
doaj +1 more source
Human Fcγ-receptors selectively respond to C-reactive protein (CRP) isoforms
Abstract The pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ-receptors (FcγRs).
Anna Henning +8 more
openaire +1 more source
Rheumatology &Autoimmunity, EarlyView.Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura +3 more
wiley +1 more source
Serum Amyloid A in Inflammatory Rheumatic Diseases: A Compendious Review of a Renowned Biomarker
Frontiers in Immunology, 2021 Serum amyloid A (SAA) is an acute phase protein with a significant importance for patients with inflammatory rheumatic diseases (IRD). The central role of SAA in pathogenesis of IRD has been confirmed by recent discoveries, including its involvement in ...
Iva Sorić Hosman +3 more
doaj +1 more source
Rheumatology &Autoimmunity, EarlyView.This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues +6 more
wiley +1 more source
Haptoglobin in Juvenile Idiopathic Arthritis
Pediatric Rheumatology Online Journal, 2022 Background Haptoglobin (Hp), a liver derived acute phase inflammatory protein (APP), has scarcely been studied in juvenile idiopathic arthritis (JIA). Hp can occur in blood as two isoforms (Hp1 and Hp2) in precursor and mature forms.
Lillemor Berntson +5 more
doaj +1 more source
Frontiers in Psychiatry, 2022 IntroductionSuicide is the fourth leading cause of death in youth. Previous suicide attempts are among the strongest predictors of future suicide re-attempt.
Erika Abrial +23 more
doaj +1 more source
The presence of c-reactive protein (CRP) isoforms during murine wound healing
, 2013 Native C reactive protein (nCRP) is a pentameric oligoprotein composed of 5 identical protomers. Levels of this acute phase protein increase up to 1000 fold with the onset of inflammation; dissociation into single subunits creates a new isoform known as modified/monomeric CRP (mCRP).
openaire +2 more sources
Acta Paediatrica, EarlyView.ABSTRACT Aims To investigate the association between serum ALP levels and the development of AKI in paediatric patients with sepsis. Methods Retrospective screening of a computerized database of 4 Israeli regional hospitals for children (0–18 years) hospitalized between 1.01.2000–1.06.2024 with ICD‐9 sepsis‐related diagnoses (study group) and age‐ and ...
Evgenia Gurevich +5 more
wiley +1 more source