Results 31 to 40 of about 631,469 (197)

Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation

Microbial Cell Factories, 2023
Background A number of antimicrobial peptides (AMPs) hold promise as new drugs owing to their potent bactericidal activity and because they are often refractory to the development of drug resistance.
Yuchi Song, Yi Wang, Shaonan Yan, Kiminori Nakamura, Takashi Kikukawa, Tokiyoshi Ayabe, Tomoyasu Aizawa   +6 more
doaj   +1 more source

In vitro generation and bioactivity evaluation of C-reactive protein intermediate. [PDF]

PLoS ONE, 2018
The conformational conversion of pentameric C-reactive protein (pCRP) to monomeric CRP (mCRP) has been shown to play important roles in the action of CRP in inflammation regulation.
Jian-Min Lv, Ming-Yu Wang
doaj   +1 more source

Role of High-Sensitivity C-reactive Protein (Hs-CRP) in Non-communicable Diseases: A Review

Cureus, 2022
Non-communicable diseases like cardiovascular diseases, cerebrovascular diseases, diabetes mellitus, and cancer are very common causes of death worldwide.
Tanvi Banait, Anil Wanjari, Vedika Danade, Shashank Banait, J. Jain   +4 more
semanticscholar   +1 more source

C-reactive protein, immunothrombosis and venous thromboembolism

Frontiers in Immunology, 2022
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of proteins and is often used in clinical practice as a marker of infection and inflammation.
Caroline Dix, Caroline Dix, Johannes Zeller, Johannes Zeller, Hannah Stevens, Hannah Stevens, Hannah Stevens, Steffen U. Eisenhardt, Karen S. Cheung Tung Shing, Karen S. Cheung Tung Shing, Tracy L. Nero, Tracy L. Nero, Craig J. Morton, Craig J. Morton, Craig J. Morton, Michael W. Parker, Michael W. Parker, Michael W. Parker, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen   +24 more
doaj   +1 more source

C-reactive protein in major depressive disorder: Promise and challenge

Journal of Affective Disorders Reports, 2022
Depressive disorders are characterized by persistent low mood, loss of interest and pleasure, decreased energy, varying levels of social and occupational dysfunction.
Angelos Halaris, Danika Prochaska, Ashley Stefanski, Maria Filip   +3 more
doaj   +1 more source

The Multiple Faces of C-Reactive Protein—Physiological and Pathophysiological Implications in Cardiovascular Disease

Molecules, 2019
C-reactive protein (CRP) is an intriguing protein which plays a variety of roles in either physiological or pathophysiological states. For years it has been regarded merely as a useful biomarker of infection, tissue injury and inflammation, and it was ...
Magdalena Boncler, Yi Wu, Cezary Watala
doaj   +1 more source

A novel phosphocholine‐mimetic inhibits a pro‐inflammatory conformational change in C‐reactive protein

EMBO Molecular Medicine, 2022
C‐reactive protein (CRP) is an early‐stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert ...
Johannes Zeller, Karen S Cheung Tung Shing, Tracy L Nero, James D McFadyen, Guy Krippner, Balázs Bogner, Sheena Kreuzaler, Jurij Kiefer, Verena K Horner, David Braig, Habiba Danish, Sara Baratchi, Mark Fricke, Xiaowei Wang, Michel G Kather, Bernd Kammerer, Kevin J Woollard, Prerna Sharma, Craig J Morton, Geoffrey Pietersz, Michael W Parker, Karlheinz Peter, Steffen U Eisenhardt   +22 more
doaj   +1 more source

Dissociation of C-Reactive Protein Localizes and Amplifies Inflammation: Evidence for a Direct Biological Role of C-Reactive Protein and Its Conformational Changes

Frontiers in Immunology, 2018
C-reactive protein (CRP) is a member of the pentraxin superfamily that is widely recognized as a marker of inflammatory reactions and cardiovascular risk in humans.
James D. McFadyen, James D. McFadyen, James D. McFadyen, Jurij Kiefer, David Braig, Julia Loseff-Silver, Lawrence A. Potempa, Steffen Ulrich Eisenhardt, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +10 more
doaj   +1 more source

The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis

Journal of Lipid Research, 2007
C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with β2-glycoprotein I (β2GPI), implicating oxLDL/β2GPI complexes as putative autoantigens ...
Masako Tabuchi, Katsumi Inoue, Hitomi Usui-Kataoka, Kazuko Kobayashi, Misako Teramoto, Koji Takasugi, Kenichi Shikata, Masahiro Yamamura, Kenji Ando, Keiichiro Nishida, Junko Kasahara, Noriaki Kume, Luis R. Lopez, Kazuaki Mitsudo, Masakiyo Nobuyoshi, Tatsuji Yasuda, Toru Kita, Hirofumi Makino, Eiji Matsuura   +18 more
doaj   +1 more source

Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

Frontiers in Immunology, 2020
Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6.
Kiminori Nakamura, Kiminori Nakamura, Yuki Yokoi, Rie Fukaya, Shuya Ohira, Ryuga Shinozaki, Takuto Nishida, Mani Kikuchi, Tokiyoshi Ayabe, Tokiyoshi Ayabe   +9 more
doaj   +1 more source