Results 21 to 30 of about 631,469 (197)

IL-6 regulates induction of C-reactive protein gene expression by activating STAT3 isoforms

Molecular Immunology, 2022
C-reactive protein (CRP) is synthesized in hepatocytes. The serum concentration of CRP increases dramatically during the acute phase response. In human hepatoma Hep3B cells, maximal CRP expression occurs in cells treated with the combination of IL-6 and ...
D. N. Ngwa, Asmita Pathak, A. Agrawal
semanticscholar   +2 more sources

Neutralization of viral infectivity by zebrafish c-reactive protein isoforms

Molecular Immunology, 2017
HighlightsSeven C‐reactive protein isoforms were studied in zebrafish.Transcript (crp) and protein (CRP) levels changed heterogeneously after viral infections.Some of the crp1‐7/CRP1‐7 neutralized and protected against viral infections.Most anti‐viral ...
Alberto Falcó, Julio Coll, Regla María Medina-Gali   +2 more
exaly   +2 more sources

Investigating the Association of Gene Expression of IL-37 Isoforms a and b and Serum IL-37 with Rheumatoid Arthritis Activity and Severity

Medical Journal of Babylon
Background: New rheumatoid arthritis (RA) biomarkers, such as serum interleukin-37, may aid in the identification and management as well as improved monitoring of disease severity, activity, and effectiveness of the therapy.
Furqan Hasan Razzaq, Rana Fadhil Obaid
doaj   +2 more sources

C-reactive protein: the nexus between inflammation and protein misfolding diseases

Frontiers in Immunology
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Abhishek Roy, Abhishek Roy, Johannes Zeller, Johannes Zeller, Tracy L. Nero, Tracy L. Nero, Tracy L. Nero, Johanna Klepetko, Steffen U. Eisenhardt, Michael W. Parker, Michael W. Parker, Michael W. Parker, James D. McFadyen, James D. McFadyen, James D. McFadyen, James D. McFadyen, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter, Karlheinz Peter   +19 more
doaj   +2 more sources

Cell membranes and liposomes dissociate C-reactive protein (CRP) to form a new, biologically active structural intermediate: mCRP(m).

FASEB Journal, 2007
Emerging evidence indicates that C‐reactive protein (CRP) has at least two conformationally distinct isoforms, i.e., pentameric CRP (pCRP) and monomeric CRP (mCRP or CRP subunit).
Li Zhu, Shang-Rong Ji
exaly   +2 more sources

C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP

Analytical and Bioanalytical Chemistry, 2011
Native C-reactive protein (CRP) is composed of five identical subunits arranged in a pentameric structure (pCRP). Binding of pCRP to damaged cell membranes produces a second isoform, modified CRP, which has similar antigenicity to isolated monomeric ...
Joshua C Black, Min S Wang, Scott M. Reed   +2 more
exaly   +2 more sources

Extracellular DNA, hyaluronic acid, HIF pathways, and LncRNAs as predictive biomarkers of severe COVID-19

Virology Journal
The clinical course of COVID-19 ranges from mild symptoms to severe complications, and common laboratory markers such as D-dimer, ferritin, interleukin-6 (IL-6), and C-reactive protein (CRP) often do not accurately predict which patients will develop ...
Evgen Dubrovskyi, Tetiana Drevytska, Alla Portnychenko, Victor Dosenko, Iryna Halabitska, Pavlo Petakh, Denis E. Kainov, Oleksandr Kamyshnyi   +7 more
doaj   +2 more sources

An aptamer specifically targeting mCRP ameliorates experimental arthritis

Journal of Orthopaedic Translation
Background: Recent evidence highlights the important role of the liver–bone axis in the development of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The liver secretes various factors that impact joint health, one of which is
Zhuqian Wang, Duoli Xie, Peixi Zhu, Jianmin Guo, Chunhao Cao, Yu Du, Aiping Lu, Chao Liang   +7 more
doaj   +2 more sources

Exploring the Interplay Between Glycated Albumin, AGEs, and Inflammation in Old Patients with CKD

Metabolites
Introduction: Chronic kidney disease (CKD) increases cardiovascular risk through mechanisms such as oxidative stress and the accumulation of advanced glycation end products (AGEs).
Simone Vettoretti, Lara Caldiroli, Paolo Molinari, Amanda Villa, Massimiliano M. Corsi Romanelli, Elena Vianello, Elena Dozio, Simonetta Genovesi   +7 more
doaj   +2 more sources

C-Reactive Protein in Atherosclerosis—More than a Biomarker, but not Just a Culprit

Reviews in Cardiovascular Medicine, 2023
C-reactive protein (CRP) is a pentraxin that is mainly synthesized in the liver in response to inflammatory cytokines. It exists in two functionally and structurally distinct isoforms.
Kürsat Kirkgöz
doaj   +1 more source