Results 11 to 20 of about 631,469 (197)
Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator [PDF]
Frontiers in ImmunologyMost early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Marc Potempa +4 more
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Arthritis Research & Therapy, 2022 Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a large production of autoantibodies and deficient clearance of cellular waste.
Jesper Karlsson +5 more
doaj +2 more sources
Frontiers in Immunology, 2023 The differing roles of the pentameric (p) and monomeric (m) C-reactive protein (CRP) isoforms in viral diseases are not fully understood, which was apparent during the COVID-19 pandemic regarding the clinical course of severe acute respiratory syndrome ...
Francis R. Hopkins +16 more
doaj +2 more sources
Frontiers in Immunology, 2021 C-reactive protein (CRP) was first recognized in the 1940s as a protein that appeared in blood during acute episodes of infectious disease. Its presence and pharmacodynamics were found in essentially all diseases that involved tissue damage and ...
Lawrence A. Potempa +3 more
doaj +2 more sources
The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages
Frontiers in Immunology, 2018 Inflammation is regulated by many endogenous factors including estrogen, a steroid hormone that declines with increasing age, leading to excessive inflammation in the elderly. C-reactive protein (CRP) is an acute phase inflammatory protein that exists in
Nicola R. Sproston +4 more
doaj +2 more sources
C-Reactive Protein and Cancer—Diagnostic and Therapeutic Insights
Frontiers in Immunology, 2020 Cancer disease describes any pathology involving uncontrolled cell growth. As cells duplicate, they can remain localized in defined tissues, forming tumor masses and altering their microenvironmental niche, or they can disseminate throughout the body in ...
Peter C. Hart +3 more
doaj +2 more sources
The combination of CRP isoforms with oxLDL decreases TNF-α and IL-6 release by U937-derived macrophages. [PDF]
Biomed Rep, 2017 Krayem I, Bazzi S, Karam M.
europepmc +2 more sources
Monomeric C-reactive Protein as a Mediator of Chronic Inflammation in Obesity. [PDF]
CureusObesity is associated with persistent low-grade inflammation. This inflammation results from interactions between adipose tissue, immune cells, and metabolic pathways. High-sensitivity C-reactive protein (CRP) serves as a marker for systemic inflammation
Pentek A, Bacârea A.
europepmc +2 more sources
Antioxidants, 2022 Background: in patients with chronic kidney disease (CKD), the inflammatory and pro-oxidant milieu may contribute to malnutrition development. In this study, we investigated the relationship between inflammation, advanced glycation end-products (AGEs ...
Lara Caldiroli +7 more
doaj +2 more sources
How C-Reactive Protein Structural Isoforms With Distinctive Bioactivities Affect Disease Progression
Frontiers in Immunology, 2020 C-reactive protein (CRP) is a widely known, hepatically synthesized protein whose blood levels change rapidly and pronouncedly in response to any tissue damaging event associated with an inflammatory response.
Ibraheem M. Rajab +2 more
doaj +2 more sources