The Role of Anti-mCRP Autoantibodies in Lupus Nephritis
Kidney Diseases, 2023 Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
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The plasma level of mCRP is linked to cardiovascular disease in antineutrophil cytoplasmic antibody-associated vasculitis [PDF]
Arthritis Research & Therapy, 2020 Background C-reactive protein (CRP) has two natural isomers: C-reactive protein pentamer (pCRP) and C-reactive protein monomer (mCRP). The levels of CRP are significantly elevated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ...
Kai-Li Wu +5 more
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The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. [PDF]
PLoS ONE, 2014 The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result ...
Masaaki Fujita +3 more
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Frontiers in Immunology, 2023 ObjectiveThe aim of this study is to explore the prevalence and clinicopathological associations between anti-C1qA08 antibodies and anti-monomeric CRP (mCRP) a.a.35-47 antibodies and to explore the interaction between C1q and mCRP.MethodsNinety patients ...
Xiao-Ling Liu +17 more
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IgG4-related acute interstitial nephritis and the potential role of mCRP autoantibodies: a case report [PDF]
Renal Failure, 2019 Background: IgG4-related acute tubulointerstitial nephritis is a type of autoimmune-mediated interstitial nephritis. Recently, autoantibodies against modified C-reactive protein (mCRP) were found to play a pathogenic role in renal diseases through the ...
Lei Pu, Ping Zhang, Guisen Li
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Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes [PDF]
Laboratory Investigation, 2021 C-reactive protein (CRP) is an acute-phase protein that is used as an established biomarker to follow disease severity and progression in a plethora of inflammatory diseases. However, its pathophysiologic mechanisms of action are still poorly defined and remain elusive. CRP, in its pentameric form, exhibits weak anti-inflammatory activity.
Clara Ruiz-Fernández +12 more
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mCRP-Associated Vascular Pathophysiology in Progression and Outcome of Intracerebral Hemorrhage. [PDF]
Int J Mol SciMonomeric C-reactive protein (mCRP), derived from the dissociation of the native pentameric CRP (pCRP), has been implicated in the pathophysiology of various neurological conditions, particularly intracerebral hemorrhage (ICH) and neurodegenerative diseases.
Șalari G, Slevin M.
europepmc +2 more sources
The XGBoost Model Versus the Logistic Regression Model Created Based on Serum Markers in Predicting the Risk of Post-Stroke Cognitive Impairment Following Acute Ischemic Stroke. [PDF]
Brain BehavFrom 261 acute ischemic stroke patients (training n = 183, testing n = 78), we collected demographic data, cognitive assessments, and serum indicators. LassoCV identified sensitive predictors including VE‐Cad, NIHSS score, CRP, age, drinking history, education years.
Yang X +5 more
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pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics [PDF]
Frontiers in Immunology, 2018 Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important disease states including cardiovascular disease and neurodegenerative disorders such as Alzheimer's ...
Vittorio Caprio +15 more
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CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm.
PLoS ONE, 2021 ObjectiveThe molecular mechanisms of the degeneration of the aortic wall in abdominal aortic aneurysm (AAA) are poorly understood. The monomeric form of C-reactive protein (mCRP) is deposited in damaged cardiovascular organs and aggravates the prognosis;
Eun Na Kim +9 more
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