mCRP-Associated Vascular Pathophysiology in Progression and Outcome of Intracerebral Hemorrhage [PDF]
International Journal of Molecular SciencesMonomeric C-reactive protein (mCRP), derived from the dissociation of the native pentameric CRP (pCRP), has been implicated in the pathophysiology of various neurological conditions, particularly intracerebral hemorrhage (ICH) and neurodegenerative diseases.
Mark Slevin
exaly +5 more sources
mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA
Frontiers in Immunology, 2022 BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Chitose Fujita +11 more
doaj +3 more sources
A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]
BMC BiologyBackground C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu +17 more
doaj +3 more sources
pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics [PDF]
Frontiers in Immunology, 2018 Circulating C-reactive protein (CRP) is a key acute-phase protein and one of the main clinical biomarkers for inflammation and infection. CRP is an important upstream mediator of inflammation and is associated with the onset of a number of important disease states including cardiovascular disease and neurodegenerative disorders such as Alzheimer's ...
Vittorio Caprio +15 more
core +12 more sources
The Role of Anti-mCRP Autoantibodies in Lupus Nephritis
Kidney Diseases, 2023 Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj +3 more sources
Monomeric C-reactive protein and local inflammatory reaction in the wall of the coronary arteries in patients with stable coronary artery disease [PDF]
Российский кардиологический журнал, 2019 Aim. To study the phenotype of microvesicles circulating in the blood plasma of patients with stable coronary artery disease (CAD), carrying monomeric C-reactive protein (mCRP) on their surface, and to detect tissue accretions of mCRP in coronary artery ...
I. S. Melnikov +6 more
doaj +2 more sources
High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome [PDF]
Journal of Medical Biochemistry, 2018 PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly ...
Kraszewska-Glomba Barbara +3 more
doaj +2 more sources
Acetylcholine Inhibits Monomeric C-Reactive Protein Induced Inflammation, Endothelial Cell Adhesion, and Platelet Aggregation; A Potential Therapeutic? [PDF]
Frontiers in Immunology, 2018 Objectives: In this study, we examined the possibility of using targeted antibodies and the potential of small molecular therapeutics (acetylcholine, nicotine and tacrine) to block the pro-inflammatory and adhesion-related properties of monomeric C ...
Mark Slevin +18 more
doaj +2 more sources
Role of MCRP in the clinical management and the pathophysiology of the acute coronary syndromes
Introduction: The rise in emergency department admissions for chest pain necessitates a quicker and more specific test for the different acute coronary syndromes. For a non-ST elevated myocardial infarction (NSTEMI) diagnosis, the current Gold Standard requires at least one cTn (cTn) value above the 99th percentile of a reference population across 12h ...
Catrin Rebeca Austin (24032379)
openaire +3 more sources
Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety-Like Behaviors. [PDF]
Adv Sci (Weinh)ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several
Chen Z, Li X.
europepmc +2 more sources