Results 11 to 20 of about 1,079 (142)

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis

Kidney Diseases, 2023
Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj   +3 more sources

The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP [PDF]

Angiogenesis, 2023
Abstract Monomeric C-reactive protein (mCRP) plays a role in cerebrovascular damage mediated by apolipoprotein E4 (ApoE4) in Alzheimer's disease (AD) pathogenesis. Using proteomic profilings, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosphorylated tau (pTau) and the actin ...
Wei Qiao Qiu, Zhengrong Zhang, Weiwei Lin, Qini Gan, Maohua Lei, Bin Gong, Chao Zhang, Jessica Henrique, Jingyan Han, Hua Tian, Qiushan Tao, Lawrence Potempa, Thor Stein, Andrew Emili   +13 more
openaire   +3 more sources

C-reactive protein dissociation drives choroidal neovascularization in age-related macular degeneration [PDF]

Scientific Reports
Choroidal neovascularization (CNV) and inflammation play an important role in retinal disease development and the acute phase reactant C-reactive protein (CRP) has been shown to contribute to Age-related macular degeneration (AMD) in vitro.
Maria Hernandez, Sara Romero-Vázquez, Sergio Recalde, Jaione Bezunartea, Maite Moreno Orduña, Idoia Belza-Zuazu, Alfredo García-Layana, Alfredo Adán, Patricia Fernández-Robredo, Blanca Molins   +9 more
doaj   +2 more sources

Higher monomeric C-reactive protein levels are associated with premature coronary artery disease [PDF]

Frontiers in Immunology
IntroductionChronic inflammation is a major risk factor for coronary artery disease (CAD). Currently, the inflammatory cardiovascular risk is assessed via C-reactive protein (CRP) levels measured using a high-sensitivity assay (hsCRP).
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Sergey Okhota, Sergey Okhota, Olga Saburova, Yuliya Avtaeva, Tatiana Kuznetsova, Konstantin Guria, Lyudmila Prokofieva, Tatiana Riazantseva, Tatiana Riazantseva, Shang-Rong Ji, Yi Wu, Zufar Gabbasov   +14 more
doaj   +2 more sources

The XGBoost Model Versus the Logistic Regression Model Created Based on Serum Markers in Predicting the Risk of Post‐Stroke Cognitive Impairment Following Acute Ischemic Stroke [PDF]

Brain and Behavior, Volume 16, Issue 4, April 2026.
From 261 acute ischemic stroke patients (training n = 183, testing n = 78), we collected demographic data, cognitive assessments, and serum indicators. LassoCV identified sensitive predictors including VE‐Cad, NIHSS score, CRP, age, drinking history, education years.
Xiaofeng Yang, Xianwen Li, Yanfeng Wu, Qian Zhang, Juan Chen, Fengjiao Zhao   +5 more
wiley   +2 more sources

Monomeric C-reactive protein is associated with severity and prognosis of decompensated hepatitis B cirrhosis [PDF]

Frontiers in Immunology
C-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao, Ping Yuan, Zhao-Ming Tang, Zhao-Ming Tang, Jia-Geng Lei, Ze-Rui Yang, Ze-Rui Yang, Mustafa Ahmed, Mustafa Ahmed, Zhen-Yu Yao, Dan Liang, Dan Liang, Yi Wu, Yi Wu, Hai-Yun Li, Hai-Yun Li   +15 more
doaj   +2 more sources

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]

Frontiers in Immunology
IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar, Víctor Llorenç, Víctor Llorenç, Marc Figueras-Roca, Marc Figueras-Roca, Maite Sainz de-la-Maza, Maite Sainz de-la-Maza, Alfredo Adán, Alfredo Adán, Blanca Molins   +9 more
doaj   +2 more sources

C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway [PDF]

Frontiers in Immunology
IntroductionT cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection.
Julia Thomé, Julia Limmer, Julia Limmer, Teresa Z. Brose, Johannes Zeller, Nina Chevalier, Nina Chevalier, Anna-Lena Schäfer, Laura Schneider, Maike Lind, Thierry Christmann, Marie Dreck, Sheena Kreuzaler, David Braig, Karlheinz Peter, Franziska Pankratz, Steffen U. Eisenhardt   +16 more
doaj   +2 more sources

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +2 more sources

Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis

Mediators of Inflammation, 2023
Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of the local inflammatory response. This study investigated the circulating and local levels of mCRP and their relevance to clinicopathological ...
Mo Yuan, Xiao-ling Liu, Ying Tan, Feng Yu, Ming-hui Zhao   +4 more
doaj   +1 more source