Results 21 to 30 of about 1,780 (172)

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +2 more sources

Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety-Like Behaviors. [PDF]

Adv Sci (Weinh)
ABSTRACT The previous study elucidated that the C‐reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis‐associated anxiety‐like behaviors in rats. This molecular crosstalk along the periodontal‐hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several
Chen Z, Li X.
europepmc   +2 more sources

Tubulointerstitial Nephritis With Uveitis (TINU) Syndrome: A Case Series and Review of Literature. [PDF]

Nephrology (Carlton)
ABSTRACT Tubulointerstitial nephritis with uveitis (TINU) syndrome is a rare disorder characterised by the simultaneous or sequential occurrence of acute tubulointerstitial nephritis and uveitis, in the absence of systemic disease. Its true prevalence is likely underestimated, as renal and ocular manifestations may not appear concurrently. We conducted
Ali W, Agrawal N, Sinha S, Poulikakos D, Choudhury J, Chrysochou C.   +5 more
europepmc   +2 more sources

CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm.

PLoS ONE, 2021
ObjectiveThe molecular mechanisms of the degeneration of the aortic wall in abdominal aortic aneurysm (AAA) are poorly understood. The monomeric form of C-reactive protein (mCRP) is deposited in damaged cardiovascular organs and aggravates the prognosis;
Eun Na Kim, Jiyoung Yu, Joon Seo Lim, Hwangkyo Jeong, Chong Jai Kim, Jae-Sung Choi, So Ra Kim, Hee-Sung Ahn, Kyunggon Kim, Se Jin Oh   +9 more
doaj   +1 more source

Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia

Biomedicines, 2021
Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its experimentally proven ability to promote dementia with Alzheimer’s ...
Elisa García-Lara, Samuel Aguirre, Núria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Suñol, Rubén Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeliu   +12 more
doaj   +1 more source

PEMBANGUNAN BERKELANJUTAN (SUSTAINABLE DEVELOPMENT)

, 2018
Pembangunan Berkelanjutan (Sustainable Development) disampaikan oleh Ir. Mulyono Sadyohutomo, MCRP sebagai praktisi Tata Ruang dan Pertanahan. Materi Kuliah Tamu "Green and Friendly Environment" Program Studi Perencanaan Wilayah dan Kota Fakultas Teknik ...
Ir. Mulyono Sadyohutomo, MCRP
core   +3 more sources

The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
The high-sensitivity C-reactive protein (hsCRP) assay measures the level of the pentameric form of CRP in blood. Currently, there are no available assays measuring the level of the monomeric form of CRP (mCRP), produced at sites of local inflammation. We
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Olga Pogorelova, Maria Tripoten, Leyla Khamchieva, Olga Saburova, Yuliya Avtaeva, Maria Zvereva, Evgeny Matroze, Evgeny Matroze, Tatiana Kuznetsova, Lyudmila Prokofieva, Tatiana Balakhonova, Tatiana Balakhonova, Zufar Gabbasov   +15 more
doaj   +1 more source

Proteomic profiles and comparison of identified proteomes among the AAA-high mCRP, AAA-low mCRP, and AAD groups.

, 2021
(A) Two-dimensional principal component analysis plots using quantitative protein information. (B) Venn diagram showing the overlap of differentially expressed proteins among the three groups.
Chong Jai Kim (8828177), Eun Na Kim (3234693), Hee-Sung Ahn (823274), Se Jin Oh (8786870), So Ra Kim (11326717), Joon Seo Lim (3939407), Jae-Sung Choi (238255), Kyunggon Kim (414536), Jiyoung Yu (414538), Hwangkyo Jeong (11326714)   +9 more
core   +1 more source

Relación entre la expresión de proteínas inhibidoras de complemento y la eficacia terapéutica de anticuerpos en cáncer de mama

Gaceta Médica de México, 2022
Se ha propuesto a las proteínas reguladoras de complemento (mCRP) CD55, CD46 y CD59 como piezas clave en la resistencia terapéutica contra el cáncer.
Rebeca E. Montalvo-Castro, Nohemí Salinas-Jazmín   +1 more
doaj   +1 more source

Monomeric C-Reactive Protein Localized in the Cerebral Tissue of Damaged Vascular Brain Regions Is Associated With Neuro-Inflammation and Neurodegeneration-An Immunohistochemical Study

Frontiers in Immunology, 2021
Monomeric C-reactive protein (mCRP) is now accepted as having a key role in modulating inflammation and in particular, has been strongly associated with atherosclerotic arterial plaque progression and instability and neuroinflammation after stroke where ...
Raid S. Al-Baradie, Shuang Pu, Shuang Pu, Donghui Liu, Yasmin Zeinolabediny, Glenn Ferris, Coral Sanfeli, Ruben Corpas, Elisa Garcia-Lara, Suliman A. Alsagaby, Bader M. Alshehri, Ahmed M. Abdel-hadi, Fuzail Ahmad, Psalm Moatari, Nima Heidari, Mark Slevin, Mark Slevin   +16 more
doaj   +1 more source