Results 21 to 30 of about 1,079 (142)

Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia

Biomedicines, 2021
Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its experimentally proven ability to promote dementia with Alzheimer’s ...
Elisa García-Lara, Samuel Aguirre, Núria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Suñol, Rubén Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeliu   +12 more
doaj   +1 more source

The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
The high-sensitivity C-reactive protein (hsCRP) assay measures the level of the pentameric form of CRP in blood. Currently, there are no available assays measuring the level of the monomeric form of CRP (mCRP), produced at sites of local inflammation. We
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Olga Pogorelova, Maria Tripoten, Leyla Khamchieva, Olga Saburova, Yuliya Avtaeva, Maria Zvereva, Evgeny Matroze, Evgeny Matroze, Tatiana Kuznetsova, Lyudmila Prokofieva, Tatiana Balakhonova, Tatiana Balakhonova, Zufar Gabbasov   +15 more
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Relación entre la expresión de proteínas inhibidoras de complemento y la eficacia terapéutica de anticuerpos en cáncer de mama

Gaceta Médica de México, 2022
Se ha propuesto a las proteínas reguladoras de complemento (mCRP) CD55, CD46 y CD59 como piezas clave en la resistencia terapéutica contra el cáncer.
Rebeca E. Montalvo-Castro, Nohemí Salinas-Jazmín   +1 more
doaj   +1 more source

Monomeric C-Reactive Protein Localized in the Cerebral Tissue of Damaged Vascular Brain Regions Is Associated With Neuro-Inflammation and Neurodegeneration-An Immunohistochemical Study

Frontiers in Immunology, 2021
Monomeric C-reactive protein (mCRP) is now accepted as having a key role in modulating inflammation and in particular, has been strongly associated with atherosclerotic arterial plaque progression and instability and neuroinflammation after stroke where ...
Raid S. Al-Baradie, Shuang Pu, Shuang Pu, Donghui Liu, Yasmin Zeinolabediny, Glenn Ferris, Coral Sanfeli, Ruben Corpas, Elisa Garcia-Lara, Suliman A. Alsagaby, Bader M. Alshehri, Ahmed M. Abdel-hadi, Fuzail Ahmad, Psalm Moatari, Nima Heidari, Mark Slevin, Mark Slevin   +16 more
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Role of ischemic preconditioning in cardioprotective mechanisms of mCRP deposited myocardium in a rat model [PDF]

, 2020
Abstract The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. We evaluated the effects of IPC on mCRP-deposited myocardium due to IRI in a rat model. Myocardial IRI was
Kim, Eun Na, Choi, Jae-Sung, Kim, Chong Jai, Kim, So Ra, Kim, Ki-Bong, Oh, Se Jin   +5 more
openaire   +1 more source

Competition between distinct ApoE alleles and mCRP for the endothelial receptor CD31 differentially regulates neurovascular inflammation and Alzheimer’s disease pathology [PDF]

, 2021
Abstract BACKGROUND C-reactive protein (CRP) in peripheral inflammation is associated with increased Alzheimer’s disease (AD) risk in Apolipoprotein E4 (ApoE4), but not ApoE3 or E2, humans. It remains unknown whether peripheral monomeric CRP (mCRP) induces AD pathogenesis through some receptor of ...
Zhengrong Zhang, Hana Na, Qini Gan, Qiushan Tao, Yuriy Alekseyev, Junming Hu, Zili Yan, Jack B. Yang, Hua Tian, Shenyu Zhu, Qiang li, Ibraheem M. Rajab, Jan Krizysztof Blusztajn, Benjamin Wolozin, Andrew Emili, Xiaoling Zhang, Thor Stein, Lawrence A. Potempa, Wei Qiao Qiu   +18 more
openaire   +1 more source

Serum C-reactive protein is an important and powerful prognostic biomarker in most adult solid tumors. [PDF]

PLoS ONE, 2018
INTRODUCTION:Prognostication in cancer is challenging and inaccurate. C-Reactive Protein (CRP), a cheap and sensitive marker of inflammation may help. This study investigated the relationship between CRP and prognosis in a large cohort of solid tumors ...
Shiva Shrotriya, Declan Walsh, Amy S Nowacki, Cliona Lorton, Aynur Aktas, Barbara Hullihen, Nabila Benanni-Baiti, Katherine Hauser, Serkan Ayvaz, Bassam Estfan   +9 more
doaj   +1 more source

Monomeric C-reactive protein and local inflammatory reaction in the wall of the coronary arteries in patients with stable coronary artery disease

Российский кардиологический журнал, 2019
Aim. To study the phenotype of microvesicles circulating in the blood plasma of patients with stable coronary artery disease (CAD), carrying monomeric C-reactive protein (mCRP) on their surface, and to detect tissue accretions of mCRP in coronary artery ...
I. S. Melnikov, S. G. Kozlov, P. V. Chumachenko, O. S. Saburova, O. A. Guseva, L. V. Prokofyeva, Z. A. Gabbasov   +6 more
doaj   +1 more source

Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity

Arthritis Research & Therapy, 2022
Background Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a large production of autoantibodies and deficient clearance of cellular waste.
Jesper Karlsson, Jonas Wetterö, Maria Weiner, Johan Rönnelid, Rafael Fernandez-Botran, Christopher Sjöwall   +5 more
doaj   +1 more source

C-Reactive Protein in Atherosclerosis—More than a Biomarker, but not Just a Culprit

Reviews in Cardiovascular Medicine, 2023
C-reactive protein (CRP) is a pentraxin that is mainly synthesized in the liver in response to inflammatory cytokines. It exists in two functionally and structurally distinct isoforms.
Kürsat Kirkgöz
doaj   +1 more source