Mediators of Inflammation, 2023 Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of the local inflammatory response. This study investigated the circulating and local levels of mCRP and their relevance to clinicopathological ...
Mo Yuan +4 more
doaj +2 more sources
Monomeric CRP regulates inflammatory responses in human intervertebral disc cells [PDF]
Bone & Joint Research, 2023 Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández +10 more
doaj +3 more sources
Role of ischemic preconditioning in cardioprotective mechanisms of mCRP deposited myocardium in a rat model [PDF]
bioRxiv, 2020 The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. We evaluated the effects of IPC
Eun Na Kim +5 more
semanticscholar +2 more sources
Monomeric C-Reactive Protein Localized in the Cerebral Tissue of Damaged Vascular Brain Regions Is Associated With Neuro-Inflammation and Neurodegeneration-An Immunohistochemical Study [PDF]
Frontiers in Immunology, 2021 Monomeric C-reactive protein (mCRP) is now accepted as having a key role in modulating inflammation and in particular, has been strongly associated with atherosclerotic arterial plaque progression and instability and neuroinflammation after stroke where ...
Raid S. Al-Baradie +16 more
doaj +2 more sources
High prevalence of autoantibodies against monomeric C reactive protein (CRP) in children with PFAPA syndrome [PDF]
Journal of Medical Biochemistry, 2018 PFAPA (periodic fever, aphthous stomatitis, pharyngitis, cervical adenitis) syndrome is an autoinflammatory disorder of unknown etiology. The aim of our study was to evaluate whether the presence of anti-mCRP autoantibodies (anti-mCRP) might possibly ...
Kraszewska-Glomba Barbara +3 more
doaj +2 more sources
The plasma levels of mCRP is linked to cardiovascular disease in antineutrophil cytoplasmic antibody -associated vasculitis [PDF]
, 2020 Background C-reactive protein (CRP) has 2 natural isomers, C-reactive protein pentamer (pCRP) and C-reactive protein monomer (mCRP). The levels of CRP are significantly elevated in patients with anti-neutrophil cytoplasmic antibody（ANCA)-associated ...
Kaili Wu +4 more
semanticscholar +2 more sources
Российский кардиологический журнал, 2019 Aim. To study the phenotype of microvesicles circulating in the blood plasma of patients with stable coronary artery disease (CAD), carrying monomeric C-reactive protein (mCRP) on their surface, and to detect tissue accretions of mCRP in coronary artery ...
I. S. Melnikov +6 more
doaj +3 more sources
The Pathogenic Role of C-Reactive Protein in Diabetes-Linked Unstable Atherosclerosis. [PDF]
Int J Mol SciC-reactive protein (CRP) has long been recognized as a biomarker of systemic inflammation and cardiovascular disease (CVD) risk. However, emerging evidence highlights the distinct and potent pro-inflammatory role of its monomeric form (mCRP), which is ...
Sibianu M, Slevin M.
europepmc +2 more sources
Monomeric C-reactive protein is associated with severity and prognosis of decompensated hepatitis B cirrhosis [PDF]
Frontiers in ImmunologyC-reactive protein (CRP) is an acute-phase protein produced by the liver in response to infection and during chronic inflammatory disorders. Systemic inflammation is a major driver of cirrhosis progression from the compensated to the decompensated stage.
Ning Gao +15 more
doaj +2 more sources
From Homeostasis To Inflammation To Autoimmunity: The Potential Impact of CRP. [PDF]
InflammationC-reactive protein (CRP) is a highly conserved pentraxin, synthesized primarily in the liver, and is widely recognized as a highly sensitive biomarker for inflammation and tissue damage.
Ahmed M +7 more
europepmc +2 more sources