Results 21 to 30 of about 3,242 (179)

mCRP triggers angiogenesis by inducing F3 transcription and TF signalling in microvascular endothelial cells [PDF]

Thrombosis and Haemostasis, 2017
SummaryInflammation contributes to vascular disease progression. However, the role of circulating inflammatory molecules on microvascular endothelial cell (mECs) is not fully elucidated. The aim of this study was to investigate the effects of the short pentraxin CRP on microvascular endothelial cell angiogenic function.
Peña, E, De La Torre, R, Arderiu, G, Slevin, M, Badimon, L   +4 more
openaire   +5 more sources

Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis

Mediators of Inflammation, 2023
Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of the local inflammatory response. This study investigated the circulating and local levels of mCRP and their relevance to clinicopathological ...
Mo Yuan, Xiao-ling Liu, Ying Tan, Feng Yu, Ming-hui Zhao   +4 more
doaj   +1 more source

Monomeric CRP regulates inflammatory responses in human intervertebral disc cells

Bone & Joint Research, 2023
Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández, Djedjiga Ait Eldjoudi, Maria González-Rodríguez, Alfonso Cordero Barreal, Yousof Farrag, Lucia García-Caballero, Francisca Lago, Ali Mobasheri, Daisuke Sakai, Jesús Pino, Oreste Gualillo   +10 more
doaj   +1 more source

The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
The high-sensitivity C-reactive protein (hsCRP) assay measures the level of the pentameric form of CRP in blood. Currently, there are no available assays measuring the level of the monomeric form of CRP (mCRP), produced at sites of local inflammation. We
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Olga Pogorelova, Maria Tripoten, Leyla Khamchieva, Olga Saburova, Yuliya Avtaeva, Maria Zvereva, Evgeny Matroze, Evgeny Matroze, Tatiana Kuznetsova, Lyudmila Prokofieva, Tatiana Balakhonova, Tatiana Balakhonova, Zufar Gabbasov   +15 more
doaj   +1 more source

Complement factor H binding of monomeric C-reactive protein downregulates proinflammatory activity and is impaired with at risk polymorphic CFH variants [PDF]

, 2017
Inflammation and immune-mediated processes are pivotal to the pathogenic progression of age-related macular degeneration (AMD). Although plasma levels of C-reactive protein (CRP) have been shown to be associated with an increased risk for AMD, the ...
Adán Civera, Alfredo, Antón, Rosa, Aróstegui Gorospe, Juan Ignacio, Dick, Andrew D., Fuentes Prior, Pablo, Molins Monteys, Blanca, Yagüe, Jordi   +6 more
core   +6 more sources

Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia

Biomedicines, 2021
Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its experimentally proven ability to promote dementia with Alzheimer’s ...
Elisa García-Lara, Samuel Aguirre, Núria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Suñol, Rubén Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeliu   +12 more
doaj   +1 more source

Relación entre la expresión de proteínas inhibidoras de complemento y la eficacia terapéutica de anticuerpos en cáncer de mama

Gaceta Médica de México, 2022
Se ha propuesto a las proteínas reguladoras de complemento (mCRP) CD55, CD46 y CD59 como piezas clave en la resistencia terapéutica contra el cáncer.
Rebeca E. Montalvo-Castro, Nohemí Salinas-Jazmín   +1 more
doaj   +1 more source

Monomeric C-Reactive Protein Localized in the Cerebral Tissue of Damaged Vascular Brain Regions Is Associated With Neuro-Inflammation and Neurodegeneration-An Immunohistochemical Study

Frontiers in Immunology, 2021
Monomeric C-reactive protein (mCRP) is now accepted as having a key role in modulating inflammation and in particular, has been strongly associated with atherosclerotic arterial plaque progression and instability and neuroinflammation after stroke where ...
Raid S. Al-Baradie, Shuang Pu, Shuang Pu, Donghui Liu, Yasmin Zeinolabediny, Glenn Ferris, Coral Sanfeli, Ruben Corpas, Elisa Garcia-Lara, Suliman A. Alsagaby, Bader M. Alshehri, Ahmed M. Abdel-hadi, Fuzail Ahmad, Psalm Moatari, Nima Heidari, Mark Slevin, Mark Slevin   +16 more
doaj   +1 more source

TEO-MCRP: Thermal exchange optimization-based clustering routing protocol with a mobile sink for wireless sensor networks

Journal of King Saud University - Computer and Information Sciences, 2022
Sensor nodes consume their energy quickly due to their continuous perception, routing, and internal circuit mechanisms in Wireless Sensor Networks (WSNs). Especially, the nodes that are close to the sink node consume their energy more quickly, causing the hot spot problem.
Sercan Yalçın, Ebubekir Erdem
openaire   +2 more sources

Factor H-Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation. [PDF]

, 2015
The physiological roles of the factor H (FH)-related proteins are controversial and poorly understood. Based on genetic studies, FH-related protein 5 (CFHR5) is implicated in glomerular diseases, such as atypical hemolytic uremic syndrome, dense deposit
Bánlaki, Zsófia, Csincsi, Ádám, Józsi, Mihály, Kopp, Anne, Uzonyi, Barbara, Zöldi, Miklós   +5 more
core   +4 more sources