Results 21 to 30 of about 1,814 (179)

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
doaj   +1 more source

CRP immunodeposition and proteomic analysis in abdominal aortic aneurysm.

PLoS ONE, 2021
ObjectiveThe molecular mechanisms of the degeneration of the aortic wall in abdominal aortic aneurysm (AAA) are poorly understood. The monomeric form of C-reactive protein (mCRP) is deposited in damaged cardiovascular organs and aggravates the prognosis;
Eun Na Kim, Jiyoung Yu, Joon Seo Lim, Hwangkyo Jeong, Chong Jai Kim, Jae-Sung Choi, So Ra Kim, Hee-Sung Ahn, Kyunggon Kim, Se Jin Oh   +9 more
doaj   +1 more source

Monomeric CRP regulates inflammatory responses in human intervertebral disc cells

Bone & Joint Research, 2023
Aims: CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined.
Clara Ruiz-Fernández, Djedjiga Ait Eldjoudi, Maria González-Rodríguez, Alfonso Cordero Barreal, Yousof Farrag, Lucia García-Caballero, Francisca Lago, Ali Mobasheri, Daisuke Sakai, Jesús Pino, Oreste Gualillo   +10 more
doaj   +1 more source

The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP

Angiogenesis, 2023
Abstract Monomeric C-reactive protein (mCRP) plays a role in cerebrovascular damage mediated by apolipoprotein E4 (ApoE4) in Alzheimer's disease (AD) pathogenesis. Using proteomic profilings, we found altered cytoskeleton proteins in the microvasculature of AD brains, including increased levels of hyperphosphorylated tau (pTau) and the actin ...
Wei Qiao Qiu, Zhengrong Zhang, Weiwei Lin, Qini Gan, Maohua Lei, Bin Gong, Chao Zhang, Jessica Henrique, Jingyan Han, Hua Tian, Qiushan Tao, Lawrence Potempa, Thor Stein, Andrew Emili   +13 more
openaire   +2 more sources

Urinary Modified C-Reactive Protein is Closely Associated with Tubulointerstitial Lesions in Lupus Nephritis

Mediators of Inflammation, 2023
Objective. Modified C-reactive protein (mCRP) is known to be involved in the upregulation and amplification of the local inflammatory response. This study investigated the circulating and local levels of mCRP and their relevance to clinicopathological ...
Mo Yuan, Xiao-ling Liu, Ying Tan, Feng Yu, Ming-hui Zhao   +4 more
doaj   +1 more source

Antibody Protection against Long-Term Memory Loss Induced by Monomeric C-Reactive Protein in a Mouse Model of Dementia

Biomedicines, 2021
Monomeric C-reactive protein (mCRP), the activated isoform of CRP, induces tissue damage in a range of inflammatory pathologies. Its detection in infarcted human brain tissue and its experimentally proven ability to promote dementia with Alzheimer’s ...
Elisa García-Lara, Samuel Aguirre, Núria Clotet, Xenia Sawkulycz, Clara Bartra, Lidia Almenara-Fuentes, Cristina Suñol, Rubén Corpas, Peter Olah, Florin Tripon, Andrei Crauciuc, Mark Slevin, Coral Sanfeliu   +12 more
doaj   +1 more source

The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
The high-sensitivity C-reactive protein (hsCRP) assay measures the level of the pentameric form of CRP in blood. Currently, there are no available assays measuring the level of the monomeric form of CRP (mCRP), produced at sites of local inflammation. We
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Olga Pogorelova, Maria Tripoten, Leyla Khamchieva, Olga Saburova, Yuliya Avtaeva, Maria Zvereva, Evgeny Matroze, Evgeny Matroze, Tatiana Kuznetsova, Lyudmila Prokofieva, Tatiana Balakhonova, Tatiana Balakhonova, Zufar Gabbasov   +15 more
doaj   +1 more source

Proteomic profiles and comparison of identified proteomes among the AAA-high mCRP, AAA-low mCRP, and AAD groups.

, 2021
(A) Two-dimensional principal component analysis plots using quantitative protein information. (B) Venn diagram showing the overlap of differentially expressed proteins among the three groups.
Chong Jai Kim (8828177), Eun Na Kim (3234693), Hee-Sung Ahn (823274), Se Jin Oh (8786870), So Ra Kim (11326717), Joon Seo Lim (3939407), Jae-Sung Choi (238255), Kyunggon Kim (414536), Jiyoung Yu (414538), Hwangkyo Jeong (11326714)   +9 more
core   +1 more source

Relación entre la expresión de proteínas inhibidoras de complemento y la eficacia terapéutica de anticuerpos en cáncer de mama

Gaceta Médica de México, 2022
Se ha propuesto a las proteínas reguladoras de complemento (mCRP) CD55, CD46 y CD59 como piezas clave en la resistencia terapéutica contra el cáncer.
Rebeca E. Montalvo-Castro, Nohemí Salinas-Jazmín   +1 more
doaj   +1 more source

Tubulointerstitial Nephritis With Uveitis (TINU) Syndrome: A Case Series and Review of Literature. [PDF]

Nephrology (Carlton)
ABSTRACT Tubulointerstitial nephritis with uveitis (TINU) syndrome is a rare disorder characterised by the simultaneous or sequential occurrence of acute tubulointerstitial nephritis and uveitis, in the absence of systemic disease. Its true prevalence is likely underestimated, as renal and ocular manifestations may not appear concurrently. We conducted
Ali W, Agrawal N, Sinha S, Poulikakos D, Choudhury J, Chrysochou C.   +5 more
europepmc   +2 more sources