Results 191 to 200 of about 23,062,194 (220)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Monomeric CRP is prevalent in the blood of patients with rheumatoid arthritis and correlates with clinically relevant markers. [PDF]

Front Immunol
Ferreira AC, Martin-Gutierrez L, Lalaurie C, Feehan K, Lakhani P, Buckle I, Robinson GA, Jury EC, Manson JJ, McDonnell TCR.   +9 more
europepmc   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Calcium-dependent conformational transitions and ligand binding regulation of C-reactive protein: a comprehensive review. [PDF]

Front Immunol
Cheng B, Yao ZX, Wu GQ.
europepmc   +1 more source

Molecular Glue Degraders in Early Development for Cancer Therapy

Medicinal Research Reviews, EarlyView.
ABSTRACT Molecular glue degraders are an emerging class of small molecule allosteric modulators that induce or stabilize protein‐protein interactions, enabling targeted degradation of previously intractable proteins. By redirecting E3 ligases to recognize neosubstrates, proteins that are not typically recognized by a specific E3 ubiquitin ligase, they ...
E. Sila Ozdemir, Hyunbum Jang, Ozlem Keskin, Attila Gursoy, Ruth Nussinov   +4 more
wiley   +1 more source

Ambient light drives verteporfin-induced protein cross-linking during standard laboratory sample processing. [PDF]

PLoS One
Baroutis KG, Corrêa VSMC, Ntentakis D, Narimatsu T, Gragoudas ES, Miller JW, Young LH, Vavvas DG.   +7 more
europepmc   +1 more source

Spectroscopic Evidence of Free Radicals Generated by Indocyanine Green Under Light Irradiation. [PDF]

Molecules
Szpunar M, Dubiel Ł, Cieniek B, Stefaniuk I, Aebisher D, Wal A.   +5 more
europepmc   +1 more source

Retardation of human insulin amyloid fibrillation by vitamin B1. [PDF]

RSC Adv
Paul S, Mondal F, Islam R, Begum S, Dalui R, Sepay N, Halder UC.   +6 more
europepmc   +1 more source

Biotin- and Chloroalkane-Modified Nucleotides for Dual Display of Proteins on DNA Through Streptavidin and Halotag Binding. [PDF]

Angew Chem Int Ed Engl
Liuni G, Slavětínská LP, Hájek M, Raindlová V, Hocek M.   +4 more
europepmc   +1 more source