Results 71 to 80 of about 29,796 (140)

Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]

, 2020
Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio, Dingilian, Armine I, Lupták, Andrej, Oumais, Mona, Passalacqua, Luiz FM, Szostak, Jack W   +5 more
core  

Novel role of Ras-GTPase Activating Protein SH3 Domain-Binding Protein G3BP in adhesion and migration of 32D myeloid progenitor cells [PDF]

, 2012
Rho GTPases are involved in homing and mobilization of hematopoietic stem and progenitor cells due to their impact on cytoskeleton remodeling. We have previously shown that inhibition of Rho, Rac and Cdc42 clearly impairs adhesion of normal and leukemic ...
Aschenbrenner, Frank, Bug, Gesine, Henschler, Reinhard, Hofmann, Wolf-Karsten, Kampfmann, Manuela, Komor, Martina, Ruthardt, Martin, Rüster, Brigitte Inge, Schwarz, Kerstin   +8 more
core   +1 more source

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [PDF]

, 1994
The myristoylated form of c-Abl protein, as well as the P210bcr/abl protein, have been shown by indirect immunofluorescence to associate with F-actin stress fibers in fibroblasts. Analysis of deletion mutants of c-Abl stably expressed in fibroblasts maps
Baltimore, David, Jackson, Peter K., Janmey, Paul A., Matsudaira, Paul T., Sanders, Mitchell C., Van Etten, Richard A.   +5 more
core   +4 more sources

Revisiting the mechanism of coagulation factor XIII activation and regulation from a structure/functional perspective [PDF]

, 2016
The activation and regulation of coagulation Factor XIII (FXIII) protein has been the subject of active research for the past three decades. Although discrete evidence exists on various aspects of FXIII activation and regulation a combinatorial structure/
A Biswas, A Biswas, A Biswas, A Biswas, A Das, A Heil, A Ichinose, A Ichinose, A Malara, A Roy, AA Tymiak, B Pierce, BA Fox, BL Moore, BT Turner Jr., C Klock, CG Curtis, D Aeschlimann, D Gemmati, DA Case, DC Soares, E Katona, E Krieger, E Krieger, E Krissinel, EF Pettersen, GK Kristiansen, H Handrkova, H Raghu, I Komaromi, J Dodt, J Polgar, J Stamnaes, JB Lorand, L Lorand, L Lorand, L Lorand, L Muszbek, L Muszbek, L Simón, M Souri, M Souri, M Stieler, ML Schwartz, MS Weiss, NA Baker, NA Carrell, R Leung-Toung, RW Hooft, S Finney, S Liu, SB Baker, TH Jang, TM Sabo, TS Lai, U Grundmann, V Ivaskevicius, V Ivaskevicius, V Ivaskevicius, V Schroeder, VC Yee, VC Yee, VD Myneni, WS Hur, Y Choi, Z Bagoly, Z Wang   +66 more
core   +1 more source

Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains. [PDF]

, 2012
Formins are a conserved family of proteins known to enhance actin polymerization. Most formins are regulated by an intramolecular interaction. The Drosophila formin, Cappuccino (Capu), was believed to be an exception.
Bor, Batbileg, Phillips, Martin L, Quinlan, Margot E, Vizcarra, Christina L   +3 more
core   +2 more sources

Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistribution [PDF]

, 2014
Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are unknown. Phosphorylation of LRRK2 at Ser(910)/Ser(935) mediates interaction with 14-3-3.
Berger, Betarbet, Biosa, Biskup, Bond, Burns, Caesar, Civiero, Cookson, Daniëls, Deng, Deng, Dusonchet, Dzamko, Dzamko, Dächsel, Fabunmi, Fu, Gandhi, Gandhi, Gasper, Gotthardt, Greggio, Greggio, Greggio, Greggio, Halliday, Hardy, Hsu, Ito, Jaleel, James, Johnston, Jorgensen, Jung, Kamikawaji, Kapahi, Kedersha, Kelly, Kenney, Ko, Korecka, Li, Lobbestael, Mata, Mortiboys, Nichols, Nichols, Orenstein, Paisán-Ruíz, Pan-Montojo, Papkovskaia, Pungaliya, Riou, Roussel, Rudenko, Samikkannu, Sen, Sheng, Taymans, Waxman, Webber, West, Wigley, Yuan, Zimprich   +65 more
core   +2 more sources

Measuring ligand efficacy at the mu-opioid receptor using a conformational biosensor. [PDF]

, 2018
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects.
Livingston, Kathryn E, Mahoney, Jacob P, Manglik, Aashish, Sunahara, Roger K, Traynor, John R   +4 more
core  

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources

The interaction network of rhodopsin involving the heterotrimeric G‐protein transducin and the monomeric GTPase Rac1 is determined by distinct binding processes [PDF]

, 2014
Maike Köster, Daniele Dell’Orco, Karl‐Wilhelm Koch   +2 more
openalex   +1 more source

General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]

, 2017
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S., Diener, Dennis R., Gopal, Radhika, Ishikawa, Takashi, King, Stephen M., Liu, Yi, Maizy, Yousif, Poghosyan, Emiliya, Yang, Pinfen, Zhu, Xiaoyan   +9 more
core   +1 more source