Results 71 to 80 of about 28,236 (160)

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Co-expression of Gbeta 5 Enhances the Function of Two Ggamma Subunit-like Domain-containing Regulators of G Protein Signaling Proteins [PDF]

, 2000
Regulators of G protein signaling (RGS) stimulate the GTPase activity of G protein Galpha subunits and probably play additional roles. Some RGS proteins contain a Ggamma subunit-like (GGL) domain, which mediates a specific interaction with Gbeta 5. The
Chen, Ching-Kang, He, Wei, Kovoor, Abraham, Lester, Henry A., Simon, Melvin I., Wensel, Theodore G.   +5 more
core  

Leukotriene BLT2 receptor monomers activate the G(i2) GTP-binding protein more efficiently than dimers.

, 2010
Accumulating evidence indicates that G protein-coupled receptors can assemble as dimers/oligomers but the role of this phenomenon in G protein coupling and signaling is not yet clear. We have used the purified leukotriene B(4) receptor BLT2 as a model to investigate the capacity of receptor monomers and dimers to activate the adenylyl cyclase ...
Arcemisbehere, Laure, Sen, Tuhinadri, Boudier, Laure, Balestre, Marie-Noëlle, Gaibelet, Gérald, Detouillon, Emilie, Orcel, Hélène, Mendre, Christiane, Rahmeh, Rita, Granier, Sébastien, Vivès, Corinne, Fieschi, Franck, Damian, Marjorie, Durroux, Thierry, Baneres, Jean-Louis, Mouillac, Bernard   +15 more
openaire   +1 more source

The COOH terminus of the c-Abl tyrosine kinase contains distinct F- and G-actin binding domains with bundling activity [PDF]

, 1994
The myristoylated form of c-Abl protein, as well as the P210bcr/abl protein, have been shown by indirect immunofluorescence to associate with F-actin stress fibers in fibroblasts. Analysis of deletion mutants of c-Abl stably expressed in fibroblasts maps
Baltimore, David, Jackson, Peter K., Janmey, Paul A., Matsudaira, Paul T., Sanders, Mitchell C., Van Etten, Richard A.   +5 more
core   +4 more sources

Probing for Binding Regions of the FtsZ Protein Surface through Site-Directed Insertions: Discovery of Fully Functional FtsZ-Fluorescent Proteins

, 2016
FtsZ, a bacterial tubulin homologue, is a cytoskeletal protein that assembles into protofilaments that are one subunit thick. These protofilaments assemble further to form a “Z ring” at the center of prokaryotic cells. The Z ring generates a constriction
Erickson, Harold P., Joshi, Chandra P., Moore, Desmond A., Osawa, Masaki, Whatley, Zakiya N.   +4 more
core   +2 more sources

Single-particle imaging reveals intraflagellar transport–independent transport and accumulation of EB1 in \u3cem\u3eChlamydomonas\u3c/em\u3e flagella [PDF]

, 2016
The microtubule (MT) plus-end tracking protein EB1 is present at the tips of cilia and flagella; end-binding protein 1 (EB1) remains at the tip during flagellar shortening and in the absence of intraflagellar transport (IFT), the predominant protein ...
Harris, J. Aaron, Kner, Peter, Lechtreck, Karl F., Liu, Yi, Yang, Pinfen   +4 more
core   +1 more source

Dysregulated GPCR Signaling and Therapeutic Options in Uveal Melanoma. [PDF]

, 2017
Uveal melanoma is the most common primary intraocular malignant tumor in adults and arises from the transformation of melanocytes in the uveal tract. Even after treatment of the primary tumor, up to 50% of patients succumb to metastatic disease.
Aplin, Andrew E., Benovic, Jeffrey L., Chua, Vivian, Lapadula, Dominic, Randolph, Clinita, Wedegaertner, Philip B.   +5 more
core   +1 more source

Activation and Allostery in a Fungal SAMHD1 Hydrolase: An Evolutionary Blueprint for dNTP Catabolism. [PDF]

JACS Au
Pan L, Lachowicz JC, Paddy I, Xu Y, Yang Q, Zizola C, Milne A, Grove TL, Pandelia ME.   +8 more
europepmc   +1 more source

Crystal structures reveal nucleotide-induced conformational changes in G motifs and distal regions in human guanylate-binding protein 2. [PDF]

Commun Biol
Roy S, Wang B, Roy K, Tian Y, Bhattacharya M, Williams S, Yin Q.   +6 more
europepmc   +1 more source

Various methods to detect small GTPase activation: from radioisotope-based methods to the Small GTPase ActIvitY ANalysing (SAIYAN) system. [PDF]

J Biochem
Maeda M, Saito K.
europepmc   +1 more source