Editorial: The Mononuclear Phagocyte System in Infectious Disease [PDF]
Frontiers in Immunology, 2019 We compiled expertise of scientists of all career stages and from 23 countries and five continents to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.
Geanncarlo Lugo-Villarino +9 more
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The Peyer’s Patch Mononuclear Phagocyte System at Steady State and during Infection [PDF]
Frontiers in Immunology, 2017 The gut represents a potential entry site for a wide range of pathogens including protozoa, bacteria, viruses, or fungi. Consequently, it is protected by one of the largest and most diversified population of immune cells of the body.
Clément Da Silva +4 more
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FROM THE RETICULO-ENDOTHELIAL TO MONONUCLEAR PHAGOCYTE SYSTEM- THE UNACCOUNTED YEARS [PDF]
Frontiers in Immunology, 2015 It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this review we examine the early origins and development of macrophage research continuing after his death in 1916, through the period of the Reticulo-Endothelial ...
Simon eYona, Siamon eGordon
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Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus [PDF]
Frontiers in Immunology, 2017 The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial ...
Karen Bohmwald +5 more
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Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials [PDF]
Exploration, 2023 Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites of action, but their delivery efficacy is severely limited by a series of biological ...
Junjie Lu +6 more
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The role of mononuclear phagocyte system in IgA nephropathy: pathogenesis and prognosis [PDF]
Frontiers in Immunology, 2023 Although the “multiple hits” theory is a widely accepted pathogenesis in IgA nephropathy (IgAN), increasing evidence suggests that the mononuclear/macrophage system plays important roles in the progression of IgAN; however, the exact mechanism is unclear.
Yiwen Liu, Yiwen Liu, Yan Gong, Gaosi Xu
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Mononuclear phagocyte system blockade improves therapeutic exosome delivery to the myocardium. [PDF]
Theranostics, 2020 Rationale: Exosomes are emerging as a promising drug delivery carrier. However, rapid uptake of exosomes by the mononuclear phagocyte system (MPS) remains an obstacle for drug delivery into other targeted organs, including the heart. We hypothesized that
Wan Z +9 more
europepmc +4 more sources
Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery [PDF]
Nature CommunicationsRapid uptake of nanoparticles by mononuclear phagocyte system (MPS) significantly hampers their therapeutic efficacy. Temporal MPS blockade is one of the few ways to overcome this barrier – the approach rediscovered many times under different names but ...
Ivan V. Zelepukin +2 more
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Flt3 Regulation in the Mononuclear Phagocyte System Promotes Ocular Neovascularization [PDF]
Journal of Ophthalmology, 2018 Fms-like tyrosine kinase 3 (Flt3), a tyrosine kinase receptor expressed in CD34+ hematopoietic stem/progenitor cells, is important for both normal myeloid and lymphoid differentiation.
Yushuo Gao +8 more
doaj +4 more sources
Replication in the Mononuclear Phagocyte System (MPS) as a Determinant of Hantavirus Pathogenicity [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 Members of different virus families including Hantaviridae cause viral hemorrhagic fevers (VHFs). The decisive determinants of hantavirus-associated pathogenicity are still enigmatic.
Martin J. Raftery +8 more
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