Results 1 to 10 of about 33,934 (266)
Frontiers in Immunology, 2021 Endogenous mechanisms underlying bacterial infection resolution are essential for the development of novel therapies for the treatment of inflammation caused by infection without unwanted side effects.
Feihong Liang +10 more
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Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes
Frontiers in Immunology, 2021 The membrane attack complex (MAC) of the complement system and Perforin-1 are well characterized innate immune effectors. MAC is composed of C9 and other complement proteins that target the envelope of gram-negative bacteria.
Leidy C. Merselis +2 more
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The Delivery of Extracellular “Danger” Signals to Cytosolic Sensors in Phagocytes
Frontiers in Immunology, 2022 Phagocytes, such as macrophages and dendritic cells, possess the ability to ingest large quantities of exogenous material into membrane-bound endocytic organelles such as macropinosomes and phagosomes.
Gerone A. Gonzales +2 more
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Frontiers in Immunology, 2023 IntroductionBlood-feeding arthropods rely on robust cellular and humoral immunity to control pathogen invasion and replication. Tick hemocytes produce factors that can facilitate or suppress microbial infection and pathogenesis. Despite the importance of
Abdulsalam Adegoke +4 more
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Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions
Life, 2021 The clearance of apoptotic cells is known to be a critical step in maintaining tissue and organism homeostasis. This process is rapidly/promptly mediated by recruited or resident phagocytes. Phagocytes that engulf apoptotic cells have been closely linked
Minjoo Han +7 more
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Frontiers in Cell and Developmental Biology, 2021 How phagocytes find invading microorganisms and eliminate pathogenic ones from human bodies is a fundamental question in the study of infectious diseases.
Xuehua Xu, Miao Pan, Tian Jin
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AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke
Cell Reports, 2021 Summary: The sterile inflammation caused by damage-associated molecular patterns (DAMPs) worsens the prognosis following primary injury such as ischemic stroke. However, there are no effective treatments to regulate DAMPs.
Natsumi Maehara +8 more
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Better Together: Current Insights Into Phagosome-Lysosome Fusion
Frontiers in Immunology, 2021 Following phagocytosis, the nascent phagosome undergoes maturation to become a phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill and digest engulfed microbes, cells, and debris.
Jenny A. Nguyen +3 more
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mBio, 2023 Pyrin is a pattern-recognition receptor in phagocytes that triggers caspase-1 inflammasome assembly in response to bacterial toxins and effectors that inactivate RhoA.
Haleema S. Malik +6 more
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Frontiers in Immunology, 2017 Chronic granulomatous disease (CGD) is caused by mutations in genes that encode the NADPH-oxidase and result in a failure of phagocytic cells to produce reactive oxygen species (ROS) via this enzyme system.
Martina Sundqvist +10 more
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