Results 11 to 20 of about 33,934 (266)
Frontiers in Immunology, 2018 As invertebrates lack an adaptive immune system, they depend to a large extent on their innate immune system to recognize and clear invading pathogens.
Shuai Jiang +12 more
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eLife, 2020 Neutrophils constitute the largest population of phagocytic granulocytes in the blood of mammals. The development and function of neutrophils and monocytes is primarily governed by the granulocyte colony-stimulating factor receptor family (CSF3R/CSF3 ...
Damilola Pinheiro +3 more
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Conserved Inhibition of Neutrophil Extracellular Trap Release by Clinical Candida albicans Biofilms
Journal of Fungi, 2017 Candida albicans biofilms are difficult to eradicate due to their resistance to host defenses and antifungal drugs. Although neutrophils are the primary responder to C. albicans during invasive candidiasis, biofilms resist killing by neutrophils.
John F. Kernien +2 more
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O-Mannosylation of Proteins Enables
mBio, 2018 The ability to grow at mammalian body temperatures is critical for pathogen infection of humans. For the thermally dimorphic fungal pathogen Histoplasma capsulatum, elevated temperature is required for differentiation of mycelia or conidia into yeast ...
Andrew L. Garfoot +6 more
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Phagocytic Uptake ofEncephalitozoon cuniculiby Nonprofessional Phagocytes [PDF]
Infection and Immunity, 2000 ABSTRACTEncephalitozoon cuniculiis an obligate intracellular, spore-forming parasite belonging to the microsporidia that can cause disseminated infection in immunocompromised persons.E. cuniculispores infect host cells by germination, i.e., by explosively everting the polar filament, through which the spore contents (sporoplasms) are subsequently ...
Couzinet S +5 more
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Immunology Today, 1986 Investigators from Canada, several European countries, Israel, the Republic of South Africa and the United States of America met earlier this year∗ to discuss whether or not George Bernard Shaw's exhortation to stimulate the phagocytes' pertains equally to host defense against neoplastic cells and microorganisms.
Member of the Department of Comparative and Experimental Pathology, University of Florida, Gainesville, Florida, USA ( host institution ) +1 more
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Phagocytes and demonstration of Phagocytic activity
, 2022 In Greek, “Phagein” is for “to eat” or “devour”, and “-cyte” suffix in biology denoting “cell”. Phagocytes are cells that protect the body by ingesting harmful foreign particles, bacteria and dead or dying cells. They are essential for fighting infections and for subsequent immunity. One litre of human blood contains about six billion phagocytes.
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To stimulate the phagocytes [PDF]
Blood, 2015 “There is at bottom only one genuinely scientific treatment for all diseases, and that is to stimulate the phagocytes.” We have come a long way since this declamation by Sir Ralph Bloomfield Bonington in George Bernard Shaw’s 1906 play, The Doctor’s Dilemma.
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Fungal Symbionts Produce Prostaglandin E2 to Promote Their Intestinal Colonization
Frontiers in Cellular and Infection Microbiology, 2019 Candida albicans is a ubiquitous fungal symbiont that resides on diverse human barrier surfaces. Both mammalian and fungal cells can convert arachidonic acid into the lipid mediator, prostaglandin E2 (PGE2), but the physiological significance of fungus ...
Tze Guan Tan +4 more
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Developmental Cell, 2016 2016 marks the centenary of the death of Elie Metchnikoff, whose 19th-century studies of starfish larvae led to the description of immune cell phagocytosis. This discovery, along with follow-up studies, earned Metchnikoff the 1908 Nobel Prize in Physiology or Medicine. We have come a long way since those early discoveries. A hundred years later, we now
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