Factors Affecting the Pharmacology of Antibody–Drug Conjugates
Antibodies, 2018 Major advances in therapeutic proteins, including antibody–drug conjugates (ADCs), have created revolutionary drug delivery systems in cancer over the past decade.
Andrew T. Lucas +6 more
doaj +1 more source
Dysregulation of U12‐Type Splicing in Lupus Neutrophils
Arthritis &Rheumatology, Accepted Article.Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco +11 more
wiley +1 more source
The CNS mononuclear phagocyte system in health and disease
Neuron, 2022 S. Mundt, M. Greter, B. Becher
semanticscholar +1 more source
Macrophage Migration Is Impaired within Candida albicans Biofilms [PDF]
, 2017 Acknowledgments: We thank the Microscopy and Histology Core Facility at the University of Aberdeen. This work was funded by NHS Grampian Endowments (grant RG10191); the Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (grant ...
Alonso, Maria F. +3 more
core +2 more sources
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
Deep Immunophenotyping Reveals Endometriosis is Marked by Dysregulation of the Mononuclear Phagocytic System in Endometrium and Peripheral Blood [PDF]
, 2022 Júlia Vallvé-Juanico +11 more
openalex +1 more source
Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress-Mediated Cell Death and Fetal Loss via Type IV Secretion System-Dependent Activation of CHOP. [PDF]
, 2019 Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded protein response (UPR).
Atluri, Vidya L +14 more
core +1 more source
Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis
BMEMat, EarlyView.This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang +6 more
wiley +1 more source
FUNCTIONAL ACTIVITY CHANGES OF THE MONONUCLEAR PHAGOCYTE SYSTEM IN PATIENTS WITH RAPIDLY PROGRESSIVE GENERALIZED PERIDONTITIS WITH PERIODONTAL MICROORGANISMS SENSITIVE AND RESISTANT TO DRUGS [PDF]
, 2020 А А Гударьян, O. S. Dorogina
openalex +1 more source
Reprogramming of global histone methylation controls the differentiation of monocytes into macrophages [PDF]
, 2016 单核-巨噬细胞系统由一类具有吞噬功能的免疫细胞组成，包括单核细胞、巨噬细胞及树突状细胞，是机体免疫系统重要的组成之一。来源于造血干细胞的单核细胞在趋化因子激活下，分化为巨噬细胞和树突状细胞，参与机体防卫。目前有关单核-巨噬细胞分化的细胞学过程已基本阐释，然而分化进程中关键分子及其调控网络仍需要深入阐明。此外，单核细胞如果过度增生，会导致正常造血功能衰竭。白血病的发生也与单核-巨噬细胞系统的异常发展有关。因此，深入探索和阐明单核/巨噬细胞形成过程中关键转录因子及其调控网络 ...
王慧敏
core