Results 51 to 60 of about 32,733 (216)

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source

Phaseolus vulgaris STP13.1 is an H+‐coupled monosaccharide transporter, present in source leaves and seed coats, with higher substrate affinity at depolarized potentials

Plant Direct
Sugar transport proteins (STPs) are high‐affinity H+‐coupled hexose symporters. Recently, the contribution of STP13 to bacterial and fungal pathogen resistance across multiple plant species has garnered significant interest.
Joseph L. Pegler, John W. Patrick, Benjamin McDermott, Anthony Brown, Jackson M. J. Oultram, Christopher P. L. Grof, John M. Ward   +6 more
doaj   +1 more source

Extracellular vesicle signatures from eye lavage as novel non-invasive biomarkers for hypoxic ischaemic insult—findings from a neonatal mouse model

Frontiers in Medical Technology
Neonatal hypoxia ischaemia (HI) affects 1–3 per 1,000 live births, is a major cause of infant mortality and morbidity, and leads to adverse long-term neurological outcomes, while reliable biomarkers are scarce.
Runci Li, Sarah R. Needham, Igor Kraev, Mariya Hristova, Sigrun Lange, Sigrun Lange   +5 more
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Advance in research on the regulation of fruit sugar accumulation and quality formation in horticultural crops by sugar transporters

Guoshu xuebao
Fruit quality is a core determinant of the economic value of horticultural crops and consumer acceptance, with sugar content and composition being key indicators for evaluating flavor quality.
JIANG Fengchao, ZHANG Junhuan, YANG Li, ZHANG Meiling, YU Wenjian, SUN Haoyuan   +5 more
doaj   +1 more source

Sustainable Phosphorylated Cellulose Nanocrystals: A Dual‐Affinity Platform for High‐Efficiency Enrichment of Intact Glycopeptides and Phosphopeptides

Advanced Science, EarlyView.
AAA ABSTRACT Protein glycosylation and phosphorylation are critical post‐translational modifications (PTMs) governing nearly all cellular functions, yet their analysis remains challenging due to reliance on costly and unsustainable enrichment materials.
Jiaying Li, Wuming Fan, Xuyang Yue, Dongdong Wang, Xiangyu Tang, Zhuo Zhang, Yonggui Wang, Yanjun Xie, Mingliang Ye, Hongqiang Qin   +9 more
wiley   +1 more source

Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development. [PDF]

, 2014
UNLABELLED: Burkholderia pseudomallei is the causative agent of melioidosis, an often fatal infectious disease for which there is no vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its ...
Atkins, Bakshi, Baugh, Chong, Cuccui, Dance, Davidson, Dong, Doublet, Eckert, Figurski, Freiberg, Gallagher, Haque, Holden, Hu, Kang, Karlyshev, Langmead, Langridge, Lewenza, Lynch, Nandi, Ortega, Sadosky, Sarkar-Tyson, Shalom, Sim, Thibault, Tumapa, van Opijnen, van Opijnen, Wiersinga, Yu, Zhang   +34 more
core   +3 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Neurospora crassa transcriptomics reveals oxidative stress and plasma membrane homeostasis biology genes as key targets in response to chitosan [PDF]

, 2016
Chitosan is a natural polymer with antimicrobial activity. Chitosan causes plasma membrane permeabilization and induction of intracellular reactive oxygen species (ROS) in Neurospora crassa. We have determined the transcriptional profile of N.
Glass, N. Louise, Kowbel, David, Lopez-Llorca, Luis Vicente, Lopez-Moya, Federico, Nueda, María José, Palma-Guerrero, Javier   +5 more
core   +3 more sources

Effects of Cellulase and Lactobacillus plantarum Supplementation on Fermentation Characteristics, In Situ Degradability, and Microbial Community Dynamics of Apple Pomace Silage

Animal Research and One Health, EarlyView.
This study aimed to investigate the effects of cellulase and Lactobacillus plantarum on the silage quality, in situ digestibility, and microbial communities of apple pomace silage. The combined supplementation of cellulase and Lactobacillus plantarum in apple pomace silage improved fermentation quality and enhanced rumen utilization efficiency.
Zhuangzhuang Liu, Xiongfei Zhang, Fengbo Sun, Junhu Yao, Xinjian Lei   +4 more
wiley   +1 more source