Results 61 to 70 of about 3,766,461 (388)

The Efficacy of Vortioxetine on Anhedonia in Patients With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Background: Anhedonia is a common, persistent, and disabling phenomenon in treated adults with Major Depressive Disorder (MDD). Hitherto, relatively few antidepressant agents have been evaluated with respect to their effect on anhedonia in MDD.Methods ...
Bing Cao, Bing Cao, Caroline Park, Caroline Park, Mehala Subramaniapillai, Yena Lee, Yena Lee, Michelle Iacobucci, Rodrigo B. Mansur, Hannah Zuckerman, Lee Phan, Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre   +14 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core  

Relationships between self-reported childhood traumatic experiences, attachment style, neuroticism and features of borderline personality disorders in patients with mood disorders [PDF]

, 2017
Background: Co-occurring borderline personality disorder (BPD) features have a marked impact on treatment of patients with mood disorders. Overall, high neuroticism, childhood traumatic experiences (TEs) and insecure attachment are plausible aetiological
Aaltonen, Kari, Baryshnikov, Ilya, Heikkinen, Martti, Isometsa, Erkki, Joffe, Grigori, Karpov, Boris, Koivisto, Maaria, Melartin, Tarja, Naatanen, Petri, Rosenstrom, Tom, Suominen, Kirsi   +10 more
core   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT)

BMJ Open
Objectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change of Augmented Depression Therapy (ADepT), a novel wellbeing-focused and recovery-oriented psychological therapy for depression.Design A
Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter   +10 more
doaj   +1 more source

The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders [PDF]

, 2018
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes.
A Hayashi-Takagi, A Heinz, A J Forstner, A Meyer-Lindenberg, A Okbay, A Okbay, A Reif, A Stuhrmann, AB Niculescu, AB Niculescu, AH Fanous, AR Hariri, AR Hariri, AR Hariri, AV Kravitz, B Chih, B Dean, B Li, B Müller-Myhsok, BD Angst, BF Voight, C Colantuoni, C Esslinger, C M Hultman, C M van Duijn, C Sudlow, C Trapnell, C Zhang, CA Rietveld, Converge consortium, Cross-Disorder Group of the Psychiatric Genomics Consortium, D Kim, D-d Wu, DM Ruderfer, DP Hibar, E Castelao, FJ McMahon, FS Goes, GB Ehret, GT Konopaske, GTEx Consortium, H Cao, H Cao, H Cao, H Chang, H Kober, H Li, H Tost, H Walter, H Walter, HA Nasrallah, HM Chen, HP Blumberg, I Dudanova, IP Blair, J Hecker, J Strohmaier, JR Almeida, K Amunts, KM Harris, KM Weiss, M Grigoroiu-Serbanescu, M Landén, M Li, M Li, M Li, M Li, M Li, M M Nöthen, M Maletic-Savatic, M Matsuzaki, M Pessiglione, M Preisig, M Rietschel, MA Ferreira, MH de Moor, ML Phillips, N Akula, N Amin, N Amin, N G Martin, N Gaspard, N Grarup, N Hoshina, N Hoshina, N Tzourio-Mazoyer, P B Mitchell, P Costa, P McGuffin, P Penzes, P R Schofield, PJ Harrison, Psychiatric Genomics Consortium Bipolar Disorder Working Group, R Kotov, RA Poldrack, RJ Pruim, RS Duman, S Cichon, S Cichon, S Durnaoglu, S E Bergen, S Erk, S Erk, S Hayashi, S Kruger, S Ripke, SB Eickhoff, Schizophrenia Working Group of the Psychiatric Genomics Consortium, SM Purcell, T G Schulze, T Yagi, T Yamamoto, TB Ustun, TM Frayling, TT Chu, TW Muhleisen, X Xiao, X Zhu, Y Kong, Y Ma, Y Ma, Y Wang, Z Kutalik   +122 more
core   +4 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Age-Dependent FOSB/ΔFOSB Response to Acute and Chronic Stress in the Extended Amygdala, Hypothalamic Paraventricular, Habenular, Centrally-Projecting Edinger-Westphal, and Dorsal Raphe Nuclei in Male Rats

Frontiers in Aging Neuroscience, 2022
FOS proteins are early-responding gene products that contribute to the formation of activator protein-1. Several acute and chronic stimuli lead to Fos gene expression, accompanied by an increase of nuclear FOS, which appears to decline with aging.
László Ákos Kovács, László Ákos Kovács, Nóra Füredi, Nóra Füredi, Balázs Ujvári, Abolfazl Golgol, Balázs Gaszner, Balázs Gaszner   +7 more
doaj   +1 more source

Physical Activity Health Communication for Adults with Mood Disorders in the United States [PDF]

, 2019
Using national representative data, this study sought to examine receipt of physical activity communication and counseling among adults with mood disorders in comparison to the general population in the United States.
Keller, Abiola O., Ortiz, Angela
core   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source