Results 51 to 60 of about 347,721 (316)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

An insight into light as a chronobiological therapy in affective disorders [PDF]

, 2014
The field of chronobiology has vastly expanded over the past few decades, bringing together research from the fields of circadian rhythms and sleep. The importance of the environmental day–night cycle on our health is becoming increasingly evident as we ...
Lall, Gurprit S., Atkinson, Lynsey A., Walsh, Jacqueline M., Corlett, Sarah A., Walsh, Jacqueline, Corlett, S.A., Sarah Corlett, Jacqueline Walsh, Gurprit Lall, Lynsey Atkinson, Atkinson, Lynsey A   +10 more
core   +1 more source

NMDA receptor inhibition prevents intracellular sodium elevations in human olfactory neuroepithelial precursors derived from bipolar patients

Scientific Reports, 2022
Dysregulation of ion flux across membranes and glutamate-induced excitotoxicity appear to be important pathophysiologic abnormalities in bipolar illness. Understanding ion control and responses to ionic stress is important to decipher the pathogenesis of
Yonglin Gao, Aaron A. Mack, Carleigh Litteral, Nicholas A. Delamere, Rif S. El-Mallakh   +4 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Erythromycin-induced psychotic decompensation in a patient affected by paranoid schizophrenic psychosis

Psychiatry and Clinical Psychopharmacology, 2021
The aim of this report is to present a case of acute psychotic decompensation in a patient suffering from paranoid schizophrenic psychosis with residual symptoms, treated with erythromycin for acute bronchitis.
Branislav Ostoja Šakić, Sinisa Svetozar Babović, Zoran Milan Gajić   +2 more
doaj   +1 more source

Epigenetics in mood disorders [PDF]

Environmental Health and Preventive Medicine, 2007
Depression develops as an interaction between stress and an individual's vulnerability to stress. The effect of early life stress and a gene-environment interaction may play a role in the development of stress vulnerability as a risk factor for depression.
Patrick O, McGowan, Tadafumi, Kato
openaire   +2 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Differential diagnosis of childhood onset psychotic symptoms [PDF]

, 2013
Öz: Çocukluk çağındaki psikotik belirtilerin saptanması psikopatoloji ile yakından ilişkilidir ve psikotik bir bozukluğun işareti olabilir. Çocuklar ve gençlerde görülen psikotik bozukluklar içinde şizofreni, şizoaffektif bozukluk ve iki uçlu mizaç ...
Yüksel, Tuğba, Özcan, Özlem Özel, Elbozan, Birgül Cumurcu   +2 more
core  

Indications for Dialysis in Lithium Toxicity: A Narrative Review

Kidney and Dialysis
Lithium is the most reliable mood stabilizer available for the treatment of bipolar disorder. However, its use is limited by multiple concerns, including acute toxicity.
Irem Hacisalihoglu Aydin, Kirolos Ibrahim, Hagar Abuelazm, Tyler L. Stephenson, Eugenia Brikker, Rif S. El-Mallakh   +5 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source