Results 51 to 60 of about 311,073 (267)

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Mechanisms of rumination change in adolescent depression (RuMeChange): study protocol for a randomised controlled trial of rumination-focused cognitive behavioural therapy to reduce ruminative habit and risk of depressive relapse in high-ruminating adolescents

BMC Psychiatry, 2021
Background Adolescent-onset depression often results in a chronic and recurrent course, and is associated with worse outcomes relative to adult-onset depression.
Henrietta Roberts, Rachel H. Jacobs, Katie L. Bessette, Sheila E. Crowell, Mindy Westlund-Schreiner, Leah Thomas, Rebecca E. Easter, Stephanie L. Pocius, Alina Dillahunt, Summer Frandsen, Briana Schubert, Brian Farstead, Patricia Kerig, Robert C. Welsh, David Jago, Scott A. Langenecker, Edward R. Watkins   +16 more
doaj   +1 more source

Age-Dependent FOSB/ΔFOSB Response to Acute and Chronic Stress in the Extended Amygdala, Hypothalamic Paraventricular, Habenular, Centrally-Projecting Edinger-Westphal, and Dorsal Raphe Nuclei in Male Rats

Frontiers in Aging Neuroscience, 2022
FOS proteins are early-responding gene products that contribute to the formation of activator protein-1. Several acute and chronic stimuli lead to Fos gene expression, accompanied by an increase of nuclear FOS, which appears to decline with aging.
László Ákos Kovács, László Ákos Kovács, Nóra Füredi, Nóra Füredi, Balázs Ujvári, Abolfazl Golgol, Balázs Gaszner, Balázs Gaszner   +7 more
doaj   +1 more source

Psychotherapy of Mood Disorders

Clinical Practice & Epidemiology in Mental Health, 2014
In the last decades, psychotherapy has gained increasing acceptance as a major treatment option for mood disorders. Empirically supported treatments for major depression include cognitive behavioural therapy (CBT), interpersonal psychotherapy (IPT), behavioural therapy and, to a lesser extent, short-term psychodynamic psychotherapy.
Picardi, Angelo, Gaetano, Paola
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A randomized controlled trial of Internet-delivered guided and unguided cognitive behaviour therapy for treating depression and anxiety in UK university students: study protocol for the Nurture-U Internet CBT trial

Trials
Background Tackling poor mental health in university students is a priority in higher education. Although major depressive disorder and generalized anxiety disorder are highly prevalent among university students and predict impaired university and later ...
E.R Watkins, D Phillips, H Choueiri, A Ford, H Cook, G Taylor, R.C Kessler   +6 more
doaj   +1 more source

What do personality tests say about mood disorders? A systematic review

Acta Psychologica
Personality is considered a relevant factor in the development and maintenance of mood disorders. However, the use of different tests based on different theories complicates the generalization of results and the formulation of robust conclusions about ...
Jainan Rodrigues Barretto, Tatiane Rodrigues Brito, Pedro Henrique Nunes Souto, Mayara Salgado Moraes, Caroline Benigno Cardoso, Adriana Munhoz Carneiro, Ricardo Alberto Moreno   +6 more
doaj   +1 more source

Headache and mood disorders [PDF]

The Journal of Headache and Pain, 2005
The aim of the study was to estimate the occurrence of mood, anxiety and disability disorders in 300 patients affected by chronic daily headache and MOH, who were observed for a 16-month period in our centre. We monitored the patients on an interview basis, concerning the anamnestic data collection related to the pre-morbid period, information given by
DE FILIPPIS, Sergio, E. Salvatori, G. Coloprisco, MARTELLETTI, Paolo   +3 more
openaire   +2 more sources