Results 41 to 50 of about 678,371 (295)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT)

BMJ Open
Objectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change of Augmented Depression Therapy (ADepT), a novel wellbeing-focused and recovery-oriented psychological therapy for depression.Design A
Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter   +10 more
doaj   +1 more source

NMDA receptor inhibition prevents intracellular sodium elevations in human olfactory neuroepithelial precursors derived from bipolar patients

Scientific Reports, 2022
Dysregulation of ion flux across membranes and glutamate-induced excitotoxicity appear to be important pathophysiologic abnormalities in bipolar illness. Understanding ion control and responses to ionic stress is important to decipher the pathogenesis of
Yonglin Gao, Aaron A. Mack, Carleigh Litteral, Nicholas A. Delamere, Rif S. El-Mallakh   +4 more
doaj   +1 more source

Erythromycin-induced psychotic decompensation in a patient affected by paranoid schizophrenic psychosis

Psychiatry and Clinical Psychopharmacology, 2021
The aim of this report is to present a case of acute psychotic decompensation in a patient suffering from paranoid schizophrenic psychosis with residual symptoms, treated with erythromycin for acute bronchitis.
Branislav Ostoja Šakić, Sinisa Svetozar Babović, Zoran Milan Gajić   +2 more
doaj   +1 more source

Physical Activity Health Communication for Adults with Mood Disorders in the United States [PDF]

, 2019
Using national representative data, this study sought to examine receipt of physical activity communication and counseling among adults with mood disorders in comparison to the general population in the United States.
Keller, Abiola O., Ortiz, Angela
core   +1 more source

Epilepsy and Mood Disorders [PDF]

, 2012
Mood disorders are the most common psychiatric comorbid disorder that affects quality of life and prognosis in epilepsy. The relation between depression and epilepsy is bidirectional.
Ismail Koc, Sermin Kesebir, Sertac Guven
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The Efficacy of Vortioxetine on Anhedonia in Patients With Major Depressive Disorder

Frontiers in Psychiatry, 2019
Background: Anhedonia is a common, persistent, and disabling phenomenon in treated adults with Major Depressive Disorder (MDD). Hitherto, relatively few antidepressant agents have been evaluated with respect to their effect on anhedonia in MDD.Methods ...
Bing Cao, Bing Cao, Caroline Park, Caroline Park, Mehala Subramaniapillai, Yena Lee, Yena Lee, Michelle Iacobucci, Rodrigo B. Mansur, Hannah Zuckerman, Lee Phan, Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre, Roger S. McIntyre   +14 more
doaj   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source