Results 41 to 50 of about 347,721 (316)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
MOOD AND ANXIETY SYMPTOMS: POTENTIAL RISK INDICATORS FOR MAJOR MOOD DISORDERS AMONG HIGH-RISK OFFSPRING OF BIPOLAR PARENTS [PDF]
, 2017 Background: Bipolar disorder affects 2% of the Canadian population. Excluding family history, there have been no reliable indicators to identify who will develop the disorder.
Heisler, Courtney
core
Interrelationships between negative mood and clinical constructs: a motivational systems approach. [PDF]
, 2014 A series of three experiments was designed to test predictions from a motivational systems approach to understanding the role of clinical constructs in anxiety-based problems.
Graham C L Davey +7 more
core +1 more source
Epilepsy and mood disorders [PDF]
Epilepsia, 2007 Summary Mood disorders (MD) are a frequent comorbidity of epilepsy with a negative impact on quality of life. The higher prevalence of MD in people with epilepsy (PWE) is most likely a reflection of a bidirectional relation between the two conditions, and common pathogenic mechanisms.
openaire +2 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Impact of SARS-CoV-2 Infection on Cognitive Function: A Systematic Review
Frontiers in Psychiatry, 2021 The prevalence and etiology of COVID-19's impact on brain health and cognitive function is poorly characterized. With mounting reports of delirium, systemic inflammation, and evidence of neurotropism, a statement on cognitive impairment among COVID-19 ...
Yazen Alnefeesi +16 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Cerebellar dysregulation and heterogeneity of mood disorders [PDF]
, 2014 Edward H Tobe Department of Psychiatry, Cooper Medical School of Rowan University, Camden, NJ, USA Abstract: This paper discusses diverse studies to consider the hypothesis that cerebellar pathology supports the heterogeneous metabolic pathologies of ...
Tobe EH
core
BMJ OpenObjectives The current study aimed to explore participants’ views on the acceptability, impact and mechanisms of change of Augmented Depression Therapy (ADepT), a novel wellbeing-focused and recovery-oriented psychological therapy for depression.Design A
Rebecca Watson +10 more
doaj +1 more source
An investigation of cannabis use for insomnia in depression and anxiety in a naturalistic sample
BMC Psychiatry, 2022 Background Little is known about cannabis use for insomnia in individuals with depression, anxiety, and comorbid depression and anxiety. To develop a better understanding of distinct profiles of cannabis use for insomnia management, a retrospective ...
Nirushi Kuhathasan +3 more
doaj +1 more source