Results 41 to 50 of about 5,878 (170)

Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack. [PDF]

PLoS ONE, 2015
The opportunistic human pathogen Pseudomonas aeruginosa controls host innate immune and complement attack. Here we identify Dihydrolipoamide dehydrogenase (Lpd), a 57 kDa moonlighting protein, as the first P.
Teresia Hallström, Melanie Uhde, Birendra Singh, Christine Skerka, Kristian Riesbeck, Peter F Zipfel   +5 more
doaj   +1 more source

IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike

Frontiers in Immunology, 2022
The secreted enzyme interleukin four-induced gene 1 (IL4I1) is involved in the negative control of the adaptive immune response. IL4I1 expression in human cancer is frequent and correlates with poor survival and resistance to immunotherapy. Nevertheless,
Jérôme Gatineau, Charlotte Nidercorne, Aurélie Dupont, Marie-Line Puiffe, José L. Cohen, José L. Cohen, Valérie Molinier-Frenkel, Valérie Molinier-Frenkel, Florence Niedergang, Flavia Castellano, Flavia Castellano   +10 more
doaj   +1 more source

Moonlighting Proteins at the Candidal Cell Surface [PDF]

Microorganisms, 2020
The cell wall in Candida albicans is not only a tight protective envelope but also a point of contact with the human host that provides a dynamic response to the constantly changing environment in infection niches. Particularly important roles are attributed to proteins exposed at the fungal cell surface.
Dorota Satala, Justyna Karkowska-Kuleta, Aleksandra Zelazna, Maria Rapala-Kozik, Andrzej Kozik   +4 more
openaire   +3 more sources

Moonlighting proteins in medically relevant fungi

PeerJ, 2022
Moonlighting proteins represent an intriguing area of cell biology, due to their ability to perform two or more unrelated functions in one or many cellular compartments. These proteins have been described in all kingdoms of life and are usually constitutively expressed and conserved proteins with housekeeping functions.
Verania J. Arvizu-Rubio, Laura C. García-Carnero, Héctor Manuel Mora-Montes   +2 more
openaire   +3 more sources

Impact of c-di-GMP on the Extracellular Proteome of Rhizobium etli

Biology, 2022
Extracellular matrix components of bacterial biofilms include biopolymers such as polysaccharides, nucleic acids and proteins. Similar to polysaccharides, the secretion of adhesins and other matrix proteins can be regulated by the second messenger cyclic
María J. Lorite, Ariana Casas-Román, Lourdes Girard, Sergio Encarnación, Natalia Díaz-Garrido, Josefa Badía, Laura Baldomá, Daniel Pérez-Mendoza, Juan Sanjuán   +8 more
doaj   +1 more source

Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea [PDF]

Open Biology, 2020
Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the ...
Maura Rojas-Pirela, Diego Andrade-Alviárez, Verónica Rojas, Ulrike Kemmerling, Ana J. Cáceres, Paul A. Michels, Juan Luis Concepción, Wilfredo Quiñones   +7 more
doaj   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Nuclear IDH3A Drives Transcriptional Programs in Melanoma via the YBX1–JUN/FOS Axis

Advanced Science, EarlyView.
Genomic amplification drives aberrant nuclear localization of IDH3A in melanoma. Independent of its canonical metabolic activity, nuclear IDH3A cooperates with YBX1 to activate the c‐JUN/c‐FOS transcriptional program, while NONO facilitates its nuclear localization.
Juan Ran, Yanchun Fang, Shengming Ruan, Juling Wang, Songbai Liu, Yuan Mao, Dongsheng Hou, Yanping Wang, Zi Ye, Qiong Li, Daoxiang Zhang   +10 more
wiley   +1 more source

Protein moonlighting in parasitic protists [PDF]

Biochemical Society Transactions, 2014
Reductive evolution during the adaptation to obligate parasitism and expansions of gene families encoding virulence factors are characteristics evident to greater or lesser degrees in all parasitic protists studied to date. Large evolutionary distances separate many parasitic protists from the yeast and animal models upon which classic views of ...
openaire   +2 more sources