Results 31 to 40 of about 5,878 (170)
Integrins: Moonlighting Proteins in Invadosome Formation [PDF]
Cancers, 2019 Invadopodia are actin-rich protrusions developed by transformed cells in 2D/3D environments that are implicated in extracellular matrix (ECM) remodeling and degradation. These structures have an undoubted association with cancer invasion and metastasis because invadopodium formation in vivo is a key step for intra/extravasation of tumor cells ...
Rafael Peláez +3 more
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Moonlighting Proteins Database [PDF]
Biophysical Journal, 2011 Moonlighting proteins comprise an interesting subset of multifunctional proteins in which the two functions are found in a single polypeptide chain. They do not include proteins that are multifunctional due to gene fusions, families of homologous proteins, splice variants, or promiscuous enzyme activities.
Mani, Mathew, Jeffery, Constance
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Interaction of Leptospira elongation factor Tu with plasminogen and complement factor H: a metabolic leptospiral protein with moonlighting activities. [PDF]
PLoS ONE, 2013 The elongation factor Tu (EF-Tu), an abundant bacterial protein involved in protein synthesis, has been shown to display moonlighting activities. Known to perform more than one function at different times or in different places, it is found in several ...
Danielly G Wolff +9 more
doaj +1 more source
NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer
Biomedicines, 2021 IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to ...
Lluís Espinosa, Laura Marruecos
doaj +1 more source
The FASEB Journal, 2013 The ability of a protein to have multiple functions and be involved in different multi‐protein complexes or pathways can complicate the prediction of the protein function from sequence or structure and the annotation of sequence and structure databases.
Constance Jeffery +4 more
openaire +1 more source
Cells, 2020 Long-term potentiation (LTP) is a molecular basis of memory formation. Here, we demonstrate that LTP critically depends on fructose 1,6-bisphosphatase 2 (Fbp2)—a glyconeogenic enzyme and moonlighting protein protecting mitochondria against stress.
Przemysław Duda +6 more
doaj +1 more source
Leukocyte Membrane Enzymes Play the Cell Adhesion Game
Frontiers in Immunology, 2021 For a long time, proteins with enzymatic activity have not been usually considered to carry out other functions different from catalyzing chemical reactions within or outside the cell.
Georgina I. López-Cortés +2 more
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Conserved functional motifs and homology modelling to predict hidden moonlighting functional sites
Frontiers in Bioengineering and Biotechnology, 2015 Moonlighting functional centers within proteins can provide them with hitherto unrecognized functions. Here we review how hidden moonlighting functional centers which we define as binding sites that have catalytic activity or regulate protein function in
Helen R Irving +2 more
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A triphosphate tunnel metalloenzyme from pear (PbrTTM1) moonlights as an adenylate cyclase
Frontiers in Plant Science, 2023 Adenylyl cyclase (AC) is the vital enzyme for generating 3′,5′-cyclic adenosine monophosphate, an important signaling molecule with profound nutritional and medicinal values.
Ye Yuan +14 more
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Nature Communications, 2020 Protein-protein interactions are thought to channel substrates between consecutive enzymes during glycolysis. Here the authors show that Arabidopsis phosphoglycerate mutase and enolase can form a substrate-channelling metabolon and also play a ...
Youjun Zhang +8 more
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