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Bioinformatics and moonlighting proteins [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 Multitasking or moonlighting is the capability of some proteins to execute two or more biochemical functions. Usually, moonlighting proteins are experimentally revealed by serendipity.
Sergio eHernández +8 more
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Gene duplication and the evolution of moonlighting proteins [PDF]
Frontiers in Genetics, 2015 Gene duplication is a recurring phenomenon in genome evolution and a major driving force in the gain of biological functions. Here, we examine the role of gene duplication in the origin and maintenance of moonlighting proteins, with special focus on ...
Adriana eEspinosa-Cantú +3 more
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Lactoferrin, the Moonlighting Protein of Innate Immunity. [PDF]
Int J Mol Sci, 2023 Lactoferrin (Lf), a naturally occurring glycoprotein involved in innate immunity, was first discovered in bovine milk [...]
Cutone A +2 more
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IdentPMP: identification of moonlighting proteins in plants using sequence-based learning models [PDF]
PeerJ, 2021 Background A moonlighting protein refers to a protein that can perform two or more functions. Since the current moonlighting protein prediction tools mainly focus on the proteins in animals and microorganisms, and there are differences in the cells and ...
Xinyi Liu +6 more
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A method for identifying moonlighting proteins based on linear discriminant analysis and bagging-SVM
Frontiers in Genetics, 2022 Moonlighting proteins have at least two independent functions and are widely found in animals, plants and microorganisms. Moonlighting proteins play important roles in signal transduction, cell growth and movement, tumor inhibition, DNA synthesis and ...
Yu Chen, Sai Li, Jifeng Guo
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Moonlighting Proteins in Yeasts [PDF]
Microbiology and Molecular Biology Reviews, 2008 SUMMARY Proteins able to participate in unrelated biological processes have been grouped under the generic name of moonlighting proteins. Work with different yeast species has uncovered a great number of moonlighting proteins and shown their importance for adequate functioning of the yeast cell.
Gancedo, Carlos, Flores, Carmen-Lisset
openaire +3 more sources
Moonlighting Proteins Are Important Players in Cancer Immunology
Frontiers in Immunology, 2021 Plasticity and adaptation to environmental stress are the main features that tumor and immune system share. Except for intrinsic and high-defined properties, cancer and immune cells need to overcome the opponent’s defenses by activating more effective ...
Annalisa Adamo +5 more
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Moonlighting in Mitosis: Analysis of the Mitotic Functions of Transcription and Splicing Factors
Cells, 2020 Moonlighting proteins can perform one or more additional functions besides their primary role. It has been posited that a protein can acquire a moonlighting function through a gradual evolutionary process, which is favored when the primary and secondary ...
Maria Patrizia Somma +8 more
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Moonlighting genes harbor antisense ORFs that encode potential membrane proteins
Scientific Reports, 2023 Moonlighting genes encode for single polypeptide molecules that perform multiple and often unrelated functions. These genes occur across all domains of life. Their ubiquity and functional diversity raise many questions as to their origins, evolution, and
Kasman E. Thomas +2 more
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Microorganisms, 2021 Moonlighting proteins are proteins with more than one function. During the past 25 years, they have been found to be rather widespread in bacteria. In Bacillus subtilis, moonlighting has been disclosed to occur via DNA, protein or RNA binding or protein ...
Inam Ul Haq, Sabine Brantl
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