Results 21 to 30 of about 5,878 (170)
Moonlighting peptides with emerging function. [PDF]
PLoS ONE, 2012 Hunter-killer peptides combine two activities in a single polypeptide that work in an independent fashion like many other multi-functional, multi-domain proteins.
Jonathan G Rodríguez Plaza +15 more
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Fungal Hal3 (and Its Close Relative Cab3) as Moonlighting Proteins
Journal of Fungi, 2022 Hal3 (Sis2) is a yeast protein that was initially identified as a regulatory subunit of the Saccharomyces cerevisiae Ser/Thr protein phosphatase Ppz1.
Antonio Casamayor, Joaquín Ariño
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Frontiers in Physiology, 2015 Moonlighting proteins are a subset of multifunctional proteins characterized by their multiple, independent and unrelated biological functions. We recently set up a large-scale identification of moonlighting proteins using a protein-protein interaction ...
Andreas eZanzoni +5 more
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Computational characterization of moonlighting proteins [PDF]
Biochemical Society Transactions, 2014 Moonlighting proteins perform multiple independent cellular functions within one polypeptide chain. Moonlighting proteins switch functions depending on various factors including the cell-type in which they are expressed, cellular location, oligomerization status and the binding of different ligands at different sites.
Ishita K, Khan, Daisuke, Kihara
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Moonlighting in Rickettsiales: Expanding Virulence Landscape
Tropical Medicine and Infectious Disease, 2022 The order Rickettsiales includes species that cause a range of human diseases such as human granulocytic anaplasmosis (Anaplasma phagocytophilum), human monocytic ehrlichiosis (Ehrlichia chaffeensis), scrub typhus (Orientia tsutsugamushi), epidemic ...
Ana Luísa Matos +2 more
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Proteins moonlighting in tumor metabolism and epigenetics [PDF]
Frontiers of Medicine, 2021 AbstractCancer development is a complicated process controlled by the interplay of multiple signaling pathways and restrained by oxygen and nutrient accessibility in the tumor microenvironment. High plasticity in using diverse nutrients to adapt to metabolic stress is one of the hallmarks of cancer cells.
Lei, Lv, Qunying, Lei
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Redefining protein moonlighting
Oncotarget, 2015 We recently presented the first computational method for the large-scale identification of what we have termed "extreme multifunctional proteins" (EMF) [1]. These are proteins whose multiple functions are very dissimilar to one another. While obviously related to moonlighting proteins, we chose to coin a new term because we felt that the current ...
Chapple, Charles E, Brun, Christine
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Bacterial moonlighting proteins [PDF]
Postępy Mikrobiologii - Advancements of Microbiology, 2017 Abstract Existence of moonlighting proteins in microorganisms is a known phenomenon, yet still not well understood. Moonlighting proteins have at least two independent biological functions, which must be performed by one polypeptide chain without separation into protein domains.
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MoonProt: A Database for Proteins That Are Known to Moonlight [PDF]
The FASEB Journal, 2014 Moonlighting proteins comprise a class of multifunctional proteins in which a single polypeptide chain performs multiple biochemical functions that are not due to gene fusions, multiple RNA splice variants or pleiotropic effects. The known moonlighting proteins perform a variety of diverse functions in many different cell types and species, and ...
Mathew Mani +9 more
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The Expanding Landscape of Moonlighting Proteins in Yeasts [PDF]
Microbiology and Molecular Biology Reviews, 2016 SUMMARY Moonlighting proteins are multifunctional proteins that participate in unrelated biological processes and that are not the result of gene fusion. A certain number of these proteins have been characterized in yeasts, and the easy genetic manipulation of these microorganisms has been useful for a thorough analysis of some cases of ...
Gancedo, Carlos +2 more
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