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Pharmacogenomics and Morphine [PDF]
The Journal of Clinical Pharmacology, 2021 AbstractMorphine is an opioid analgesic indicated in the treatment of acute and chronic moderate to severe pain. From a pharmacodynamic standpoint, morphine exerts its effects by agonizing mu‐opioid receptors predominantly, resulting in analgesia and sedation.
Adaku Ofoegbu, Earl B. Ettienne
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Frontiers in Pharmacology, 2022 Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach +10 more
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Neural Regeneration Research, 2023 Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ...
Tong-Tong Lin +12 more
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Perineuronal morphine: a comparison with epidural morphine [PDF]
Anaesthesia, 1988 SummaryIn a double‐blind, randomised controlled cross‐over study the effects of perineuronal (perifemoral) injections of morphine were compared with epidural injections with the same amount of morphine in patients after knee surgery. Better pain scores were achieved during treatment with epidural morphine.
H.V. Johannsen +4 more
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Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
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Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine
iScience, 2021 Summary: Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level.
Yeting Zeng +7 more
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Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. [PDF]
PLoS ONE, 2010 BACKGROUND: Mammalian cells synthesize morphine and the respective biosynthetic pathway has been elucidated. Human neutrophils release this alkaloid into the media after exposure to morphine precursors.
Elise Glattard +15 more
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Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
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