Results 1 to 10 of about 397,909 (400)
Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +2 more
core +4 more sources
Frontiers in Pharmacology, 2022 Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach +10 more
doaj +1 more source
Neural Regeneration Research, 2023 Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ...
Tong-Tong Lin +12 more
doaj +1 more source
Differential Changes in Expression of Stress- and Metabolic-related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal [PDF]
, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Ferenczi, Szilamér +6 more
core +5 more sources
Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine
iScience, 2021 Summary: Morphine is commonly used to relieve moderate to severe pain, but repeated doses cause opioid tolerance. Here, we used ATP sensor and fiber photometry to detect prefrontal ATP level.
Yeting Zeng +7 more
doaj +1 more source
Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils. [PDF]
PLoS ONE, 2010 BACKGROUND: Mammalian cells synthesize morphine and the respective biosynthetic pathway has been elucidated. Human neutrophils release this alkaloid into the media after exposure to morphine precursors.
Elise Glattard +15 more
doaj +1 more source
Pharmacology Research & Perspectives, 2023 Morphine induces spinal 5‐hydroxytryptamine (5‐HT) release, but the role and mechanism of the spinal 5‐HT release induced by morphine are not well understood.
Shingo Nakamura +4 more
doaj +1 more source
Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2022 Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access.
Thomas Duflot +6 more
doaj +1 more source
The Journal of Physiology, 1974 1. To find the site where morphine acts when producing hyperglycaemia on injection into the cerebral ventricles in unanaesthetized cats, morphine sulphate was infused or injected through an implanted Collison cannula into different parts of the liquor space in an amount of 0·75 mg except on microinfusion into the posterior hypothalamus, when the ...
W, Feldberg, K P, Gupta
openaire +2 more sources