Results 1 to 10 of about 135,473 (192)

MORPHINE [PDF]

open access: bronzeAnesthesiology, 1959
G. M. Smith, H. K. Beecher
openalex   +2 more sources

Pharmacogenomics and Morphine [PDF]

open access: yesThe Journal of Clinical Pharmacology, 2021
AbstractMorphine is an opioid analgesic indicated in the treatment of acute and chronic moderate to severe pain. From a pharmacodynamic standpoint, morphine exerts its effects by agonizing mu‐opioid receptors predominantly, resulting in analgesia and sedation.
Adaku Ofoegbu, Earl B. Ettienne
openaire   +3 more sources

Modulation of Morphine Analgesia, Antinociceptive Tolerance, and Mu-Opioid Receptor Binding by the Cannabinoid CB2 Receptor Agonist O-1966

open access: yesFrontiers in Pharmacology, 2022
Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also demonstrated that non-selective CB agonists attenuate morphine antinociceptive tolerance. Activation of cannabinoid
Zachary W. Reichenbach   +10 more
doaj   +1 more source

Suppressing high mobility group box-1 release alleviates morphine tolerance via the adenosine 5’-monophosphate-activated protein kinase/heme oxygenase-1 pathway

open access: yesNeural Regeneration Research, 2023
Opioids, such as morphine, are the most potent drugs used to treat pain. Long-term use results in high tolerance to morphine. High mobility group box-1 (HMGB1) has been shown to participate in neuropathic or inflammatory pain, but its role in morphine ...
Tong-Tong Lin   +12 more
doaj   +1 more source

Morphine Nitrate and Morphine Acetate**Scientific Section at Detroit. [PDF]

open access: yesThe Journal of the American Pharmaceutical Association (1912), 1915
n ...
Engelhardt, H., Winters, O. E.
openaire   +3 more sources

Perineuronal morphine: a comparison with epidural morphine [PDF]

open access: yesAnaesthesia, 1988
SummaryIn a double‐blind, randomised controlled cross‐over study the effects of perineuronal (perifemoral) injections of morphine were compared with epidural injections with the same amount of morphine in patients after knee surgery. Better pain scores were achieved during treatment with epidural morphine.
H.V. Johannsen   +4 more
openaire   +3 more sources

Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]

open access: yesReviews in Clinical Medicine, 2015
Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar   +5 more
doaj   +3 more sources

Pharmacokinetic modeling of morphine and its glucuronides: Comparison of nebulization versus intravenous route in healthy volunteers

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2022
Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access.
Thomas Duflot   +6 more
doaj   +1 more source

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