Results 141 to 150 of about 339,726 (399)
Archaeometry, EarlyView., 2022 Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares +5 more
wiley +1 more source
Ketamine coadministration attenuates morphine tolerance and leads to increased brain concentrations of both drugs in the rat [PDF]
, 2015 Background and Purpose The effects of ketamine in attenuating morphine tolerance have been suggested to result from a pharmacodynamic interaction. We studied whether ketamine might increase brain morphine concentrations in acute coadministration, in ...
Coffman BL +6 more
core +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1995 The nucleus accumbens is considered a critical target of the action of drugs of abuse. In this nucleus a "shell" and a "core" have been distinguished on the basis of anatomical and histochemical criteria.
F. Pontieri, G. Tanda, G. Chiara
semanticscholar +1 more source
Exploration, EarlyView.The discovery of the glymphatic system has opened up a pathway for drug delivery to the brain by circumventing the blood‐brain barrier, which can effectively improve drug utilization. The methods of drug delivery through the glymphatic system include intrathecal injection, intranasal injection, and delivery through the meningeal lymphatic vessels.
Xiang Wang +7 more
wiley +1 more source
Optimization Hierarchy for Fair Statistical Decision Problems [PDF]
arXiv, 2019 Data-driven decision-making has drawn scrutiny from policy makers due to fears of potential discrimination, and a growing literature has begun to develop fair statistical techniques. However, these techniques are often specialized to one model context and based on ad-hoc arguments, which makes it difficult to perform theoretical analysis.
arxiv
Journal of Pharmacy and Pharmacology, 1957 Abstract A series of compounds which antagonise the depressant activity of morphine in dogs is described. The most active compounds are the previously described 2:4-diamino-5-phenylthiazole and tetrahydro-5-aminoacridine. A mixture of both substances is more active than either alone.
F H, SHAW, S, GERSHON, G A, BENTLEY
openaire +2 more sources
Effects of Early-Adolescent, Mid-Adolescent, or Adult Stress on Morphine Conditioned Place Preference [PDF]
, 2015 In light of previous work demonstrating that stress can increase subjective drug reward in adult rats, the present study investigated the influence of stress on morphine conditioned place preference (CPP) in early-adolescent, mid-adolescent, and adult ...
Shields, Chloe
core +1 more source
Journal of Neuroscience, 2013 The ventrolateral periaqueductal gray (vlPAG) is an integral locus for morphine action. Although it is clear that glia contribute to the development of morphine tolerance, to date, the investigation of their role has been limited to spinal and medullary ...
Lori N. Eidson, A. Murphy
semanticscholar +1 more source
Genome Editing Technologies to Improve Health‐Related Phytocompounds in Crops
Food Frontiers, EarlyView.ABSTRACT Due to rapid global population growth and the resulting significant increase in food demand, the world is facing an epidemic of malnutrition. Although yield improvement remains one of the main targets of breeding programs, much attention is being paid to the nutritional aspects of crops, including nutrients and bioactive compounds that are ...
Maria Dellino +4 more
wiley +1 more source
Medicines legislation and regulation in the United Kingdom 1500‐2020
British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 80-92, January 2023., 2023 The initial purposes of regulation of medicines in England, and latterly in the United Kingdom, were principally to raise government revenue, to discourage murder by poisoning and to regulate the activities of pharmacists. It was only much later that regulators sought to ensure that medicines were of good quality, reasonably safe, and at least somewhat
Robin E. Ferner, Jeffrey K. Aronson
wiley +1 more source