Results 161 to 170 of about 265,062 (307)

CoolCuddle and Autonomic Regulation in Infants With Hypoxic‐Ischaemic Encephalopathy: An Intervention Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim We evaluated the impact of ‘CoolCuddle’, parental cuddling during therapeutic hypothermia intervention for hypoxic‐ischaemic encephalopathy, on heart rate variability (HRV). Methods In this prospective, single‐group, interventional study with repeated measures, we included infants ≥ 36 weeks' gestation undergoing hypothermia and CoolCuddle
Ela Chakkarapani, Satomi Okano, David Odd, CoolCuddle Study Investigators   +3 more
wiley   +1 more source

Early Prediction of Outcome Using Lactate Dehydrogenase and Amplitude‐Integrated EEG in Transported Newborn Infants with Hypoxic–Ischaemic Encephalopathy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To investigate whether early lactate dehydrogenase (LDH) and amplitude‐integrated electroencephalography (aEEG) improve the prediction of outcome in outborn infants transported for therapeutic hypothermia. Method Secondary analysis of a randomised controlled trial (2016–2019) including 113 asphyxiated newborn infants randomised to ...
Hang T. T. Tran, Ha T. Le, Dien M. Tran, Tobias Alfvén, Linus Olson, Lena Hellstrom‐Westas   +5 more
wiley   +1 more source

The Fruit Essential oil of Cuminum cyminum L. Reduced the Acquisition but not Expression of Ineffective dose of Morphine-Induced Conditioned Place Preference in Morphine- Sensitized Mice

Journal of Medicinal Plants, 2009
Background: Cuminum cyminum fruit essential oil (FEO) dose-dependently can attenuate the expression of morphine tolerance and dependence in morphine-dependent mice.
A Haghparast, J Zarringhalam, A Khatibi, E Dianati, J Shams   +4 more
doaj  

Stress antagonizes morphine-induced analgesia in rats [PDF]

Exposure to restraint stress resulted in antagonism of the analgesic effect of administered morphine in adult male rats. This antagonism of morphine-induced analgesia by restraint stress was not affected by adrenalectomy one day prior to testing ...
Heybach, J. P., Shannon, L., Vernikos, J.   +2 more
core   +1 more source

Preclinical models for evaluating psychedelics in the treatment of major depressive disorder

British Journal of Pharmacology, EarlyView.
Psychedelic drugs have seen a resurgence in interest as a next generation of psychiatric medicines with potential as rapid‐acting antidepressants (RAADs). Despite promising early clinical trials, the mechanisms which underlie the effects of psychedelics are poorly understood.
Laith Alexander, Dasha Anderson, Luke Baxter, Matthew Claydon, James Rucker, Emma S. J. Robinson   +5 more
wiley   +1 more source

Evaluation of AT121 versus morphine on cortical neurons electrophysiology and dopamine concentrations in hippocampal cells. [PDF]

PLoS One
Elawy BE, Soukkarieh CE, Abbady AQ, Allaham SA, Deeb GM.   +4 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

BTP2, a store-operated calcium channel inhibitor, attenuates morphine antinociceptive tolerance in rats. [PDF]

Front Neurosci
Xiao W, Xiao F, Zhang Y, Zeng L.
europepmc   +1 more source

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source