Results 171 to 180 of about 162,133 (313)

The functional role of opioidergic system within the ventral tegmental area and the dentate gyrus of hippocampus in modulation of the persistent inflammatory pain in the rats. [PDF]

IBRO Neurosci Rep
Saghafi M, Azizbeigi R, Haghparast A.
europepmc   +1 more source

Surgical management of a penetrating cardiac foreign body causing tamponade in a dog: case report

Australian Veterinary Journal, EarlyView.
Background Penetrating cardiac foreign bodies are rare in dogs but can result in life‐threatening complications, including pericardial effusion and cardiac tamponade. Prompt diagnosis, emergency stabilization, and definitive surgical management are essential to achieve a favorable outcome.
RB Abibe, SC Rahal, GB Mazzali, FJT Neto, VM d V Machado, CVS Brandão   +5 more
wiley   +1 more source

J Physiol [PDF]

While respiratory complications following opioid use are mainly mediated via activation of mu opioid receptors, long-latency off-target signalling via innate immune toll-like receptor 4 (TLR4) may impair other essential elements of breathing control such

core  

Opioid-Sparing Effects of Peripheral Nerve Blocks in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis. [PDF]

Ann Transplant
Yun HJ, Kim DH, Chung MY, Min JY.
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Morphine potentiates HIV infection and receptor expression in 3d brain organoids. [PDF]

J Neurovirol
Swingler M, Tasdemir D, Cakir S, Bellizzi A, Donadoni M, Sariyer IK.   +5 more
europepmc   +1 more source

Optimal intrathecal morphine dosing for revision hip arthroplasty: an observational study

Anaesthesia, EarlyView.
Shalini Patel, Vassia Paschou, Jane Quinlan, Ben Kendrick, Nicolas Suarez   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Emerging Insights into the Distinct Pharmacological Mechanisms of Buprenorphine. [PDF]

J Chem Inf Model
Alonso-Carrasco A, Quintana-Garcia A, Ciruela-Jardí M, Casadó-Anguera V, Enten GA, Llopart N, Carrasco-Martinez B, Cai NS, Moreno E, Ferré S, Casadó V, Pardo L.   +11 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source