Results 151 to 160 of about 50,460 (257)
Asia-Pacific Journal of Clinical Oncology, EarlyView.Hydromorphone slow‐release tablet withdrawal from the Australian market altered opioid prescribing patterns in advanced cancer pain. Methadone use increased by nearly 50% and median doses doubled. There may be a need to tailor clinician training on safe and effective use of methadone and other opioids as appropriate. ABSTRACT Aim Ongoing disruptions to
Aaron K. Wong +7 more
wiley +1 more source
While respiratory complications following opioid use are mainly mediated via activation of mu opioid receptors, long-latency off-target signalling via innate immune toll-like receptor 4 (TLR4) may impair other essential elements of breathing control such
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Allergy, EarlyView.ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud +14 more
wiley +1 more source
Pharmacokinetics and Its Application to Dosage Design in Veterinary Medicine.
, 2006 The use of analgesics in veterinary medicine has increased markedly over the last two decades. Despite their increased use, little objective data is available on the efficacy of current dosage recommendations.
Kukanich, Stanley Patrick
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Anaesthesia, EarlyView.Summary Introduction The Procedure Specific Postoperative Pain Management (PROSPECT) collaboration develops evidence‐based recommendations integrating analgesic efficacy, safety and functional recovery. Since publication of the 2021 PROSPECT guidelines for total hip arthroplasty, new evidence, particularly on motor‐sparing regional techniques, has ...
Michele Carella +8 more
wiley +1 more source
Morphine-induced immunosuppression: Effects of protein kinase C activation in lymphocytes
, 1991 The present investigation describes effects of morphine on lymphocyte activation. It is reported here that bypassing the early events of signal transduction by direct protein kinase C (PKC) stimulation with phorbol myristate acetate (PMA), the initial ...
Abha Arya Saini (16768341)
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Anaesthesia, EarlyView.Summary Introduction The incidence of hip fractures is rising with the ageing population. For patients living with severe frailty and limited life expectancy, non‐operative management is increasingly considered after shared decision‐making. Given the limited availability of long‐term analgesic options, alternative techniques are needed.
Rachel J. H. Smits +24 more
wiley +1 more source
Anaesthesia, EarlyView.Summary Introduction Chronic postsurgical pain after caesarean delivery is an important cause of postpartum morbidity, yet its impact on maternal quality of life has not been comprehensively synthesised. The aims of this systematic review were to evaluate the impact of chronic postsurgical pain on quality of life, including possible temporal changes in
Samira Alwahabi +6 more
wiley +1 more source
Anaesthesia, EarlyView.Summary Introduction Day surgery is now recognised widely as being a vital component of modern healthcare delivery with overall day surgery rates in the UK now > 85%. Day surgery offers an enhanced experience for patients with reduced risk of postoperative complications (e.g.
Craig R. Bailey +8 more
wiley +1 more source
Anaesthesia, EarlyView.Summary Introduction Infiltration between the popliteal artery and the capsule of the knee (IPACK) and the selective tibial nerve block both provide analgesia for the posterior aspect of the knee after anterior cruciate ligament reconstruction. This randomised controlled triple‐blinded trial tested the hypothesis that IPACK provides superior analgesia ...
Ludovic Beun +5 more
wiley +1 more source