Results 151 to 160 of about 339,726 (399)

Evaluation of the Drug–Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling

Pharmaceutics
Background: Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide.
Shelby Coates, Keti Bardhi, Bhagwat Prasad, Philip Lazarus   +3 more
doaj   +1 more source

Behavioral Consequences of Delta-Opioid Receptor Activation in the Periaqueductal Gray of Morphine Tolerant Rats

Neural Plasticity, 2009
Chronic morphine administration shifts delta-opioid receptors (DORs) from the cytoplasm to the plasma membrane. Given that microinjection of morphine into the PAG produces antinociception, it is hypothesized that the movement of DORs to the membrane will
Michael M. Morgan, Michelle D. Ashley, Susan L. Ingram, MacDonald J. Christie   +3 more
doaj   +1 more source

Opiate Drug Seeking and Addiction: The Influence of Sucrose Consumption on the Acquisition and Expression of Morphine-induced Conditioned Place Preferences (CPP) [PDF]

, 2019
Sucrose intake may lead to changes in brain and behavior similar to the effects of abused drugs. For example, sucrose may agonize endogenous opiate systems and modulate opiate-seeking behavior.
Bakner, Lee, Berger, Isabel R., Senthithasan, Shareeta, Wolff, Stephanie   +3 more
core   +1 more source

Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study [PDF]

, 2004
BACKGROUND: The feasibility of drug monitoring of serum concentrations of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) during chronic morphine therapy is not established.
A Vermeire, C Skalke, CG Fraser, DA Karnofsky, E Bodd, HJ McQuay, Jorunn Moen, Kolbjørn Zahlsen, MA Ashby, MJ Bogusz, MT Smith, NA Hagen, O Ahokoski, Ola Dale, P Fayers, P Klepstad, P Klepstad, P Klepstad, P Sjøgren, PA Glare, Petter C Borchgrevink, Priscilla Hilton, Pål Klepstad, Q-L Gong, RK Portenoy, RT Penson, Stein Kaasa   +26 more
core   +2 more sources

Adolescent Morphine Exposure Affects Long-Term Microglial Function and Later-Life Relapse Liability in a Model of Addiction

Journal of Neuroscience, 2013
Adolescence in humans represents a unique developmental time point associated with increased risk-taking behavior and experimentation with drugs of abuse.
J. Schwarz, S. Bilbo
semanticscholar   +1 more source

Estimating the Cost and Carbon Output of Musculoskeletal Primary Care Management Decisions: A Retrospective Analysis of Electronic Health Records

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Background Healthcare accounts for up to 5% of worldwide carbon emissions and costs global economies an estimated $9 trillion annually. Primary care accounts for up to one‐fifth of all NHS carbon emissions, with musculoskeletal (MSK) pain accounting for 14%–30% of all primary care consultations.
Alex Braybrooke, Melissa Pegg, Rebecca Naylor, James Bailey, James Scott, Roanna Burgess, Dahai Yu, Simon Wathall, Kelvin P. Jordan, Robert Malcolm, Hayden Holmes, George Peat, Anirban Banerjee, Jonathan C. Hill   +13 more
wiley   +1 more source

A crossover study evaluating the sex‐dependent and sensitizing effects of sleep deprivation using a nociceptive test battery in healthy subjects

British Journal of Clinical Pharmacology, Volume 89, Issue 1, Page 361-371, January 2023., 2023
Aim We assessed whether total sleep deprivation (TSD) in combination with pain tests yields a reliable method to assess altered pain thresholds, which subsequently may be used to investigate (novel) analgesics in healthy subjects. Methods This was a two‐part randomized crossover study in 24 healthy men and 24 women.
Hemme Hijma, Ingrid Koopmans, Erica Klaassen, Robert Jan Doll, Rob Zuiker, Geert Jan Groeneveld   +5 more
wiley   +1 more source

Effects of Testosterone on Analgesia in Formalin-Treated Mice

Journal of Ardabil University of Medical Sciences, 2018
CT   Background & objectives: So far, various reports have been presented on the relationship between sex hormones and gender-related differences in pain and analgesia in humans and laboratory animals.
Akram Alijani, Rahmatoolah Parandin, Namdar Yousofvand, SHahrbanoo Oryan   +3 more
doaj  

Amniotic Fluid Ingestion Enhances\ud Opioid-Mediated But Not\ud Nonopioid-Mediated Analgesia [PDF]

, 1990
Ingestion of amniotic fluid or placenta by rats has been shown to enhance several types of opioid-mediated analgesia: that induced by morphine, footshock, vaginal/cervical stimulation, and late pregnancy.
Barton, Debra, Kristal, Dr. Mark B., Tarapacki, J. A.   +2 more
core  

Morphine as a Potential Oxidative Stress-Causing Agent

Mini-Reviews in Organic Chemistry, 2013
Morphine exhibits important pharmacological effects for which it has been used in medical practice for quite a long time. However, it has a high addictive potential and can be abused.
Jitka Škrabalová, Z. Drastichova, J. Novotný   +2 more
semanticscholar   +1 more source