Results 21 to 30 of about 397,909 (400)

Postmortem tissue distribution of morphine and its metabolites in a series of heroin related deaths [PDF]

, 2018
The abuse of heroin (diamorphine) and heroin deaths are growing around the world. The interpretation of the toxicological results from suspected heroin deaths is notoriously difficult especially in cases where there may be limited samples.
Beer, Lewis J., Crichton, Megan L., De Paoli, Giorgia, Drummond, Gail, Maskell, Peter D., Seetohul, L. Nitin, Wilson, Nathan E.   +6 more
core   +5 more sources

A synthesis of oral morphine equivalents (OME) for opioid utilisation studies

Pharmacoepidemiology and Drug Safety, 2016
Oral Morphine Equivalent (OME) doses are increasingly being used as a metric to represent opioid use. Driven by a growing need from pharmacoepidemiological studies, the objective of this study was to develop a comprehensive OME conversion table that can ...
S. Nielsen, L. Degenhardt, Bianca Hoban, N. Gisev   +3 more
semanticscholar   +1 more source

Intrathecal morphine plus general anesthesia in cardiac surgery: effects on pulmonary function, postoperative analgesia, and plasma morphine concentration

Clinics, 2009
OBJECTIVES: To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac surgery. INTRODUCTION: Lung dysfunction increases morbidity and mortality after cardiac surgery.
Luciana Moraes dos Santos, Verônica Cavani Jorge Santos, Silvia Regina Cavani Jorge Santos, Luiz Marcelo Sá Malbouisson, Maria José Carvalho Carmona   +4 more
doaj   +1 more source

Society for Obstetric Anesthesia and Perinatology Consensus Statement: Monitoring Recommendations for Prevention and Detection of Respiratory Depression Associated With Administration of Neuraxial Morphine for Cesarean Delivery Analgesia.

Anesthesia and Analgesia, 2019
The majority of women undergoing cesarean delivery in the United States receive neuraxial morphine, the most effective form of postoperative analgesia for this surgery.
J. Bauchat, C. Weiniger, P. Sultan, A. Habib, K. Ando, J. Kowalczyk, R. Kato, R. George, C. Palmer, B. Carvalho   +9 more
semanticscholar   +1 more source

Intranasal Pharmacokinetics of Morphine ARER, a Novel Abuse-Deterrent Formulation: Results from a Randomized, Double-Blind, Four-Way Crossover Study in Nondependent, Opioid-Experienced Subjects

Pain Research and Management, 2018
Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods.
Lynn R. Webster, Carmela Pantaleon, Matthew Iverson, Michael D. Smith, Eric R. Kinzler, Stefan Aigner   +5 more
doaj   +1 more source

The effect of gut microbiome on tolerance to morphine mediated antinociception in mice

Scientific Reports, 2017
There is growing appreciation for the importance of gastrointestinal microbiota in many physiological and pathophysiological processes. While morphine and other narcotics are the most widely prescribed therapy for moderate to severe pain clinically, they
Minho Kang, Ryan Mischel, S. Bhave, Essie Komla, A. Cho, Charity Huang, W. Dewey, H. Akbarali   +7 more
semanticscholar   +1 more source

The Effect of Acute and Chronic Morphine on Some Blood Biochemical ‎Parameters in an Inflammatory Condition in Gonadectomized Male Rats [PDF]

Addiction and Health, 2015
Background: Opiates affect blood factors as well as pain and inflammation in a gender-dependent manner. The aim of the present study was to evaluate the effects of morphine on serum glucose, cholesterol, triglycerides, and urea in gonadectomized and ...
Mohadeseh Chahkandi, Nayerreh Askari, Gholamreza Asadikaram   +2 more
doaj  

The effectiveness of Patient Controlled Analgesia (PCA) morphine-ketamine compared to Patient Controlled Analgesia (PCA) morphine to reduce total dose of morphine and Visual Analog Scale (VAS) in postoperative laparotomy surgery

Bali Journal of Anesthesiology, 2017
Background: Laparotomy may cause moderate to severe after surgery pain, thus adequate pain management is needed. The addition of ketamine in patient controlled analgesia (PCA) morphine after surgery can be the option.
I Gusti Ngurah Mahaalit Aribawa, Tjokorda Gde Agung Senapathi, Made Wiryana, I Ketut Sinardja, I Gede Budiarta, I Made Gede Widnyana, I Wayan Aryabiantara, Pontisomaya Parami, Pande Nyoman Kurniasari, Adinda Putra Pradhana   +9 more
doaj   +1 more source

Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study [PDF]

, 2015
Context Patients’ preference for morphine therapy has received little attention in the setting of chronic refractory breathlessness. However, this is one important factor in considering longer term therapy.
Abernethy, Amy P., Currow, David C., Ferreira, Diana H., Johnson, Miriam J., Oxberry, Stephen G., Quinn, Stephen, Silva, José P.   +6 more
core   +1 more source

Sex Differences in Microglia Activity within the Periaqueductal Gray of the Rat: A Potential Mechanism Driving the Dimorphic Effects of Morphine

Journal of Neuroscience, 2017
Although morphine remains the primary drug prescribed for alleviation of severe or persistent pain, both preclinical and clinical studies have shown that females require two to three times more morphine than males to produce comparable levels of ...
Hillary H. Doyle, Lori N. Eidson, David M. Sinkiewicz, A. Murphy   +3 more
semanticscholar   +1 more source