Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
doaj +1 more source
A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty [PDF]
, 2016 We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing ...
Anderson, K. +7 more
core +1 more source
Fentanyl depression of respiration: comparison with heroin and morphine
bioRxiv, 2019 Background and Purpose Fentanyl overdose deaths have reached ‘epidemic’ levels in North America. Death in opioid overdose invariably results from respiratory depression.
R. Hill +4 more
semanticscholar +1 more source
The Mechanisms Involved in Morphine Addiction: An Overview
International Journal of Molecular Sciences, 2019 Opioid use disorder is classified as a chronic recurrent disease of the central nervous system (CNS) which leads to personality disorders, co-morbidities and premature death.
J. Listos +5 more
semanticscholar +1 more source
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model
Scientific Reports, 2018 Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use.
Fuyuan Wang +5 more
semanticscholar +1 more source
Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study [PDF]
, 2015 © 2015 Asian Pacific Society of Respirology. Background and objective The management of chronic refractory breathlessness is one of the indications for regular low-dose (≤30 mg/24 h) oral sustained release morphine.
Abernethy, Amy P. +6 more
core +1 more source
A synthesis of oral morphine equivalents (OME) for opioid utilisation studies
Pharmacoepidemiology and Drug Safety, 2016 Oral Morphine Equivalent (OME) doses are increasingly being used as a metric to represent opioid use. Driven by a growing need from pharmacoepidemiological studies, the objective of this study was to develop a comprehensive OME conversion table that can ...
S. Nielsen +3 more
semanticscholar +1 more source
Ethanol reversal of tolerance to the respiratory depressant effects of morphine [PDF]
, 2015 Opioids are the most common drugs associated with unintentional drug overdose. Death results from respiratory depression. Prolonged use of opioids results in the development of tolerance but the degree of tolerance is thought to vary between different ...
A Fugelstad +62 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The last decade has seen an exponential increase in opioid use in the United States, resulting in a subset of the population developing opioid tolerance. In this paper, we unequivocally demonstrate that the gut microbiota plays a significant
Li Zhang +10 more
semanticscholar +1 more source
Preventing effect of vitamin E on oocytes apoptosis in morphinetreated mice [PDF]
, 2013 Several studies have shown that Morphine Sulfate affects on fertility, embryogenesis and consequent pregnancy loss and ultrastructural alterations of oocytes in animal model.
Asadi, E. +3 more
core +1 more source