Results 21 to 30 of about 235,160 (357)
Molecules, 2022 (1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Joanna Listos +8 more
doaj +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2022 Intravenous (i.v.) morphine is a safe, robust, and recommended treatment for severe pain using the titration principle. Despite its high efficacy, it is impacted by organizational constraints related to venous access.
Thomas Duflot +6 more
doaj +1 more source
Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]
Reviews in Clinical Medicine, 2015 Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar +5 more
doaj +3 more sources
Pharmacology Research & Perspectives, 2023 Morphine induces spinal 5‐hydroxytryptamine (5‐HT) release, but the role and mechanism of the spinal 5‐HT release induced by morphine are not well understood.
Shingo Nakamura +4 more
doaj +1 more source
Journal of Biomedical Science, 2009 Co-administration of dextromethorphan (DM) with morphine during pregnancy and throughout lactation has been found to reduce morphine physical dependence and tolerance in rat offspring.
Tao Pao-Luh +3 more
doaj +1 more source
Fentanyl depression of respiration: comparison with heroin and morphine
bioRxiv, 2019 Background and Purpose Fentanyl overdose deaths have reached ‘epidemic’ levels in North America. Death in opioid overdose invariably results from respiratory depression.
R. Hill +4 more
semanticscholar +1 more source
The Mechanisms Involved in Morphine Addiction: An Overview
International Journal of Molecular Sciences, 2019 Opioid use disorder is classified as a chronic recurrent disease of the central nervous system (CNS) which leads to personality disorders, co-morbidities and premature death.
J. Listos +5 more
semanticscholar +1 more source
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model
Scientific Reports, 2018 Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use.
Fuyuan Wang +5 more
semanticscholar +1 more source
Journal of Pharmacological Sciences, 2004 The present study was designed to investigate the pharmacokinetic interaction of morphine with three classes of L-type calcium channel blockers (CCB) and its relationship to morphine-induced mechanical antinociception in mice.
Norifumi Shimizu +6 more
doaj +1 more source
A synthesis of oral morphine equivalents (OME) for opioid utilisation studies
Pharmacoepidemiology and Drug Safety, 2016 Oral Morphine Equivalent (OME) doses are increasingly being used as a metric to represent opioid use. Driven by a growing need from pharmacoepidemiological studies, the objective of this study was to develop a comprehensive OME conversion table that can ...
S. Nielsen +3 more
semanticscholar +1 more source