Results 31 to 40 of about 168,528 (214)

Morphine Binds Creatine Kinase B and Inhibits Its Activity

Frontiers in Cellular Neuroscience, 2018
Morphine is an analgesic alkaloid used to relieve severe pain, and irreversible binding of morphine to specific unknown proteins has been previously observed.
Ivan Weinsanto, Jinane Mouheiche, Alexis Laux-Biehlmann, Alexis Laux-Biehlmann, François Delalande, Arnaud Marquette, Virginie Chavant, Virginie Chavant, Florian Gabel, Sarah Cianferani, Alexandre Charlet, Marie-Odile Parat, Yannick Goumon, Yannick Goumon   +13 more
doaj   +1 more source

The Effect of Memory Reinforcement by Cholinergic Agonist and Music on Creating Morphine Dependency in Mice Using Conditioned Place Preference (CPP) Method

فصلنامه دانشگاه علوم پزشکی جهرم, 2013
The most important side effect of addictive drugs is their interaction with nervous system so that soon after taking the drug, the neurons̉ connections in nervous system are addicted to receiving the drugs frequently. The aim of this study was the effect
Eebrahim Hosseini, Mokhtar Mokhtari, Akbar Vahdati, Neamat Razmi, Farnaz Tavakoli   +4 more
doaj  

Comparison between Acute and Long-Term Effects of Verapamil on Naloxane Induced Morphine Withdrawal in Mice

Journal of Research in Medical Sciences, 2004
Background: There is growing evidence indicating that neuronal calcium channels play an important role in the mechanism of Morphine dependence. Objective: To investigate the acute and long-term effects of Verapamil in Morphine dependent mice.
M Rabbani, A Jafarian, M Sobhanian
doaj  

The gamma-aminobutyric acid type B (GABA_B) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens

Behavioral and Brain Functions, 2012
Background Repeated morphine exposure can induce behavioral sensitization. There are evidences have shown that central gamma-aminobutyric acid (GABA) system is involved in morphine dependence.
Fu Zhenyu, Yang Hongfa, Xiao Yuqiang, Zhao Gang, Huang Haiyan   +4 more
doaj   +1 more source

The Role of Spinal PKCγ in Tolerance and Hyperalgesia Induced by Repeated Morphine Administration in Male Rats

Iranian South Medical Journal, 2018
Background: The aim of this study was to investigate the possible role of Protein Kinase Cᵧ (PKCᵧ) in morphine tolerance and induced hyperalgesia following repeated morphine administration in male rats.  Material and Methods: Rats were divided into
Kobra Ghasemloo, Homa Manaheji, Lila Dargahi, Sareh pandamooz   +3 more
doaj  

Evaluation of the Drug–Drug Interaction Potential of Cannabidiol Against UGT2B7-Mediated Morphine Metabolism Using Physiologically Based Pharmacokinetic Modeling

Pharmaceutics
Background: Morphine is a commonly prescribed opioid analgesic used to treat chronic pain. Morphine undergoes glucuronidation by UDP-glucuronosyltransferase (UGT) 2B7 to form morphine-3-glucuronide and morphine-6-glucuronide.
Shelby Coates, Keti Bardhi, Bhagwat Prasad, Philip Lazarus   +3 more
doaj   +1 more source

PKC-Mediated Potentiation of Morphine Analgesia by St. John’s Wort in Rodents and Humans

Journal of Pharmacological Sciences, 2014
Our purpose was to combine the use of morphine with clinically available inhibitors of protein kinase C (PKC), finally potentiating morphine analgesia in humans.
Nicoletta Galeotti, Mersedeh Farzad, Enrica Bianchi, Carla Ghelardini   +3 more
doaj   +1 more source

Comparison of Patient-Controlled Analgesia Using Morphine With and Without Paracetamol in Postoperative Pain Control [PDF]

Patient Safety and Quality Improvement Journal, 2016
Introduction: Postoperative pain control plays a pivotal role in reducing postoperative complications, hospitality time, and increasing satisfaction.
Mehryar Taghavi Gilani, Alireza Bameshki, Arash Peivandi Yazdi, Reihaneh Hasanzadeh   +3 more
doaj  

Morphine suppresses the immune function of lung cancer by up-regulating MAEL expression [PDF]

, 2022
Qichao Wang, Zhenfu Liu, Shuhong Tang, Zhen Wu   +3 more
openalex   +1 more source

Effects of Isoniazid on Tolerance and Sensitization to the Rewarding Properties of Morphine: A Conditioned Place Preference Procedure Investigation in Mice

Basic and Clinical Neuroscience, 2020
Introduction: The GABAergic system of the brain plays a key role in morphine tolerance and sensitization. As isoniazid is a modulator of the GABAergic system, the present study aims to understand whether isoniazid can influence the induction of tolerance
Amir Abbas Barzegari, Kamran Shahabi
doaj