Frontiers in Pharmacology, 2023 Introduction: The endocannabinoid system has been implicated in the neurobiology of opioid use disorder. While the CB1 receptor antagonist rimonabant has been shown to block some of the behavioral effects of opioids, studies suggest that the treatment ...
Eduardo A. V. Marinho +12 more
doaj +1 more source
Translational Psychiatry, 2022 The present study investigates the possible therapeutic effects of human mesenchymal stem cell-derived secretome on morphine dependence and relapse. This was studied in a new model of chronic voluntary morphine intake in Wistar rats which shows classic ...
María Elena Quintanilla +8 more
doaj +1 more source
Multicentre randomised controlled trial of nasal diamorphine for analgesia in children and teenagers with clinical fractures. [PDF]
, 2001 OBJECTIVE: To compare the effectiveness of nasal diamorphine spray with intramuscular morphine for analgesia in children and teenagers with acute pain due to a clinical fracture, and to describe the safety profile of the spray.
Kendall, JM +3 more
core +1 more source
Perineuronal morphine: a comparison with epidural morphine [PDF]
Anaesthesia, 1988 Summary In a double‐blind, randomised controlled cross‐over study the effects of perineuronal (perifemoral) injections of morphine were compared with epidural injections with the same amount of morphine in patients after knee surgery. Better pain scores were achieved during treatment with epidural morphine.
J B, Dahl +4 more
openaire +2 more sources
Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
Journal of Neuroinflammation, 2016 BackgroundTolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment.
Yinbing Pan +9 more
semanticscholar +1 more source
A randomised, controlled, double blind, non-inferiority trial of ultrasound-guided fascia iliaca block vs. spinal morphine for analgesia after primary hip arthroplasty [PDF]
, 2016 We performed a single centre, double blind, randomised, controlled, non-inferiority study comparing ultrasound-guided fascia iliaca block with spinal morphine for the primary outcome of 24-h postoperative morphine consumption in patients undergoing ...
Anderson, K. +7 more
core +1 more source
Morphine hydrochloride anhydrate [PDF]
Acta Crystallographica Section E Structure Reports Online, 2012 In the title mol-ecular salt [systematic name: (5α,6α)-7,8-didehydro-4,5-ep-oxy-17-methyl-morphinan-3,6-diol hydro-chloride], C17H20NO3(+)·Cl(-), the conformation of the morphinium ion is in agreement with the characteristics of the previously reported morphine forms [for example, Gylbert (1973 ▶). Acta Cryst. B29, 1630-1635].
Gelbrich, Thomas +2 more
openaire +2 more sources
Brain Reward Circuits in Morphine Addiction
Molecules and Cells, 2016 Morphine is the most potent analgesic for chronic pain, but its clinical use has been limited by the opiate’s innate tendency to produce tolerance, severe withdrawal symptoms and rewarding properties with a high risk of relapse.
Juhwan Kim +4 more
semanticscholar +1 more source
Preventing effect of vitamin E on oocytes apoptosis in morphinetreated mice [PDF]
, 2013 Several studies have shown that Morphine Sulfate affects on fertility, embryogenesis and consequent pregnancy loss and ultrastructural alterations of oocytes in animal model.
Asadi, E. +3 more
core +1 more source
On the G-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation [PDF]
, 2013 The modulatory role of allosteric receptor-receptor interactions in the pain pathways of the Central Nervous System and the peripheral nociceptors has become of increasing interest.
Agnati, Luigi F +6 more
core +3 more sources