Results 31 to 40 of about 339,726 (399)
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Pain after disease/damage of the nervous system is predominantly treated with opioids, but without exploration of the long-term consequences.
P. Grace +18 more
semanticscholar +1 more source
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog [PDF]
Eur J Pharmacol, 173174 (2020), 2020 Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on a molecular basis. Here, we examined the analgesic/adverse effect profile of a new NT(8-13) derivative denoted JMV2009, in which the Pro10 residue was substituted by a ...
arxiv +1 more source
Pain Research and Management, 2018 Objective. To investigate the pharmacokinetics (PK) of Morphine ARER, an extended-release (ER), abuse-deterrent formulation of morphine sulfate after oral and intranasal administration. Methods.
Lynn R. Webster +5 more
doaj +1 more source
Melatonin attenuates morphine‐induced conditioned place preference in Wistar rats
Brain and Behavior, 2021 Purpose Morphine is the predominantly used drug for postoperative and cancer pain management. However, the abuse potential of morphine is the primary disadvantage of using opioids in pain management.
Fahad S. Alshehri +4 more
doaj +1 more source
The effect of gut microbiome on tolerance to morphine mediated antinociception in mice
Scientific Reports, 2017 There is growing appreciation for the importance of gastrointestinal microbiota in many physiological and pathophysiological processes. While morphine and other narcotics are the most widely prescribed therapy for moderate to severe pain clinically, they
Minho Kang +7 more
semanticscholar +1 more source
It's Morphin' Time! Combating Linguistic Discrimination with Inflectional Perturbations [PDF]
, 2020 Training on only perfect Standard English corpora predisposes pre-trained neural networks to discriminate against minorities from non-standard linguistic backgrounds (e.g., African American Vernacular English, Colloquial Singapore English, etc.). We perturb the inflectional morphology of words to craft plausible and semantically similar adversarial ...
arxiv +1 more source
PolyMorphine provides extended analgesic-like effects in mice with spared nerve injury. [PDF]
, 2017 Morphine is a well-characterized and effective analgesic commonly used to provide pain relief to patients suffering from both acute and chronic pain conditions.
Chen, Renxun +5 more
core +1 more source
Journal of Neuroscience, 2017 Although morphine remains the primary drug prescribed for alleviation of severe or persistent pain, both preclinical and clinical studies have shown that females require two to three times more morphine than males to produce comparable levels of ...
Hillary H. Doyle +3 more
semanticscholar +1 more source
The Effect of Acute and Chronic Morphine on Some Blood Biochemical Parameters in an Inflammatory Condition in Gonadectomized Male Rats [PDF]
Addiction and Health, 2015 Background: Opiates affect blood factors as well as pain and inflammation in a gender-dependent manner. The aim of the present study was to evaluate the effects of morphine on serum glucose, cholesterol, triglycerides, and urea in gonadectomized and ...
Mohadeseh Chahkandi +2 more
doaj
Phosphoproteomics and bioinformatics analyses of spinal cord proteins in rats with morphine tolerance. [PDF]
PLoS ONE, 2014 Morphine is the most effective pain-relieving drug, but it can cause unwanted side effects. Direct neuraxial administration of morphine to spinal cord not only can provide effective, reliable pain relief but also can prevent the development of ...
Wen-Jinn Liaw +7 more
doaj +1 more source