Results 151 to 160 of about 11,589 (292)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Identification of Subtype-Selective Binding Sites in the Opioid Receptor Family. [PDF]

J Chem Inf Model
S Gomes AA, Guillot B, Jelsch C, Giraldo J.   +3 more
europepmc   +1 more source

Comparison of Long vs. Short Concave Neck in One‐Piece Implants Inserted 1 mm Subcrestally: A Pre‐Clinical In Vivo Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives The aim was to assess the influence of one‐piece implant concave neck height on soft‐ and hard‐tissue healing on a canine model. Material and Methods Monoblock implants with a transgingival concave neck were randomly inserted 1 mm subcrestally.
Hadi Antoun, Frank Bonnet, María Permuy Mendaña, Daniele Botticelli, Giovanna Iezzi, Morena Petrini   +5 more
wiley   +1 more source

Morphine Alkaloids and Synthetic Dibenzofuran Derivatives

, 1939
A continuation of studies patterning synthetic types after morphine alkaloids has now made possible the introduction of substituents into the critical 1-, 4-, 6- and 9-positions.
Gilman, Henry, Cook, Thomas H.
core  

Effect of Enzalutamide on Morphine Exposure in Patients with Prostate Cancer. [PDF]

Clin Pharmacokinet
Op 't Hoog CJP, Mehra N, van der Weij B, Olofsen E, Somford DM, van Oort IM, Hamberg P, van Erp NP, Boerrigter E.   +8 more
europepmc   +1 more source

Underpowered study design invalidates conclusions of LTAP versus LWI in peritoneal endometriosis surgery

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Ding Li, Song Ye
wiley   +1 more source

Enhanced Recovery After Surgery Protocol in Transoral Robotic Surgery: A Case–Control Study

Clinical Otolaryngology, EarlyView.
ABSTRACT Introduction ‘Enhanced Recovery After Surgery’ (ERAS) protocols have been developed for multiple surgical procedures with favourable outcome measures including Length of Stay (LoS). Trans‐Oral Robotic Surgery (TORS) has similarly facilitated earlier patient discharges, particularly in comparison to open head and neck surgical techniques. There
Jonathan Daniel, Raguwinder Bindy Sahota, Mark David Wilkie, Lee Pryor, Ahmed Bassiouni, Jake Jervis‐Bardy, Arun Takhar, Bora Jeong, Oladejo Olaleye, Suren Krishnan, J. C. Hodge, Andrew Foreman   +11 more
wiley   +1 more source

Semi-synthesis in the exploration of opioid-targeting natural products. [PDF]

Nat Prod Rep
Riley AP.
europepmc   +1 more source