Results 141 to 150 of about 11,589 (292)

When Urgency Drops: Temporal Consciousness and the Choreography of Dying

Anthropology of Consciousness, EarlyView.
ABSTRACT In the hospital, the transition from fighting for life to preparing for death involves not only a shift in medical repertoires but also a profound transformation in temporal experience. Drawing on ethnographic fieldwork in a Canadian intensive care unit, this article examines how the tempo of care, its rhythms, urgencies, and pauses shapes ...
Louise Chartrand
wiley   +1 more source

Shoulder‐Tip Pain After Laparoscopic Surgery: A Narrative Review of Intraperitoneal Anaesthesia

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background and Aims Shoulder‐tip pain is a common and distressing side effect following laparoscopic surgery. Standard systemic analgesic regimens are used to manage postoperative pain but are often associated with side effects such as nausea and vomiting.
Jason Arsanious, Alice Osterwalder, Sarah K. Thompson   +2 more
wiley   +1 more source

CoolCuddle and Autonomic Regulation in Infants With Hypoxic‐Ischaemic Encephalopathy: An Intervention Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim We evaluated the impact of ‘CoolCuddle’, parental cuddling during therapeutic hypothermia intervention for hypoxic‐ischaemic encephalopathy, on heart rate variability (HRV). Methods In this prospective, single‐group, interventional study with repeated measures, we included infants ≥ 36 weeks' gestation undergoing hypothermia and CoolCuddle
Ela Chakkarapani, Satomi Okano, David Odd, CoolCuddle Study Investigators   +3 more
wiley   +1 more source

The Radical Cyclization Approach to Morphine - Models for Highly Oxygenated Ring-Iii Synthons

, 1994
4-Iodo-3-methyl-2-cyclohexenone (9) and 3-alkyl 3-cyclohexene-1,2-diol derivatives 16 were examined as ring-III equivalents for the tandem radical cyclization approach to the synthesis of morphine (1a).Journal of Organic ...
Fokas, D., Parker, K. A.
core  

Early Prediction of Outcome Using Lactate Dehydrogenase and Amplitude‐Integrated EEG in Transported Newborn Infants with Hypoxic–Ischaemic Encephalopathy

Acta Paediatrica, EarlyView.
ABSTRACT Aim To investigate whether early lactate dehydrogenase (LDH) and amplitude‐integrated electroencephalography (aEEG) improve the prediction of outcome in outborn infants transported for therapeutic hypothermia. Method Secondary analysis of a randomised controlled trial (2016–2019) including 113 asphyxiated newborn infants randomised to ...
Hang T. T. Tran, Ha T. Le, Dien M. Tran, Tobias Alfvén, Linus Olson, Lena Hellstrom‐Westas   +5 more
wiley   +1 more source

Characterization of Opioid Agonist Morphine Derivatives with Emphasis on Medicinal Chemistry. [PDF]

ChemMedChem
Malik A, Hosztafi S, Vincze A, Marton A, Kraszni M, Balogh GT, Noszál B, Mazák K.   +7 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

A synthetic approach to morphine

, 1989
The synthesis of a putative intramolecular Diels-Alder reaction substrate, an intermediate in a synthetic approach to morphine, is described. The condensation reactions of several ortho-bromophenols with allylic bromides are described.
Ellwood, Charles Walter
core  

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Mitragynine and Morphine Stabilize Different Conformations of the μ‑Opioid Receptor as Revealed by Molecular Dynamics Simulation Studies. [PDF]

ACS Omega
Neupane NP, Mathews JT, Lingaraju S, You Y, Mathukumalli K, Das J.   +5 more
europepmc   +1 more source