Results 181 to 190 of about 11,589 (292)

Novel Ligands for the Orphan Receptor GPR151 Modulate Morphine Action. [PDF]

Genes Cells
Yoshida H, Suto T, Hirano H, Osada H, Nunomura K, Lin B, Saito S, Takeda S.   +7 more
europepmc   +1 more source

Characterization of the Pharmacokinetics and Physiological Effects of Tapentadol in Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Tapentadol is a dual mechanism analgesic utilizing both μ‐opioid receptor (MOR) agonism and norepinephrine reuptake inhibition (NRI). This study evaluated the pharmacokinetics and pharmacodynamics of tapentadol as a potential analgesic with the goal of treating pain in horses.
Annabella D. Lynch, Khursheed R. Mama, Dan S. McKemie, Phillip H. Kass, Heather K. Knych   +4 more
wiley   +1 more source

Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation. [PDF]

Biomol Ther (Seoul)
Huang L, Wang M, Kundu D, Paudel S, Peng L, Xian X, Jang CG, Kim KM.   +7 more
europepmc   +1 more source

Efficacy and Safety of Intra‐Articular Therapies for Temporomandibular Disorders: A Systematic Review and Meta‐Analysis

Oral Diseases, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis aimed to evaluate the most effective minimally invasive intra‐articular procedure for reducing pain and improving maximum mouth opening (MMO) in individuals diagnosed with painful articular TMD, specifically TMJ osteoarthritis and/or internal derangement.
Mateus Gaya dos Santos, Wellington Luiz de Oliveira da Rosa, Cristian Sbardelotto, Júlia Silva Gomes de Araújo, Camila da Silva Rodrigues, Noéli Boscato   +5 more
wiley   +1 more source

Investigating the Landscape of C6-Azaindole Side Chain on the Epoxymorphinan Skeleton via the Nitrogen Walk Concept: A Strategy to Enhance Drug-Like Properties. [PDF]

J Med Chem
Neel L, Ma H, Reda A, Li M, Flammia R, Woodard S, Gillespie JC, Selley DE, Dewey WL, Pagare PP, Zhang Y.   +10 more
europepmc   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Total synthesis and biological activity of "carbamorphine": O-to-CH₂ replacement in the E-ring of the morphine core structure. [PDF]

Proc Natl Acad Sci U S A
Akiyama S, Ople RS, Kremsmair A, Ramos-Gonzalez N, Nedungadan T, Kennedy BJ, Appourchaux K, Eans SO, Tsai BA, Kraml C, Huang XP, McLaughlin JP, Majumdar S, Sarpong R.   +13 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Nausea and vomiting as adverse events of oliceridine: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Pharmacol
Zeng J, Yang S, Jian J, Zhu M.
europepmc   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source