Results 111 to 120 of about 654,596 (326)

The role of homophily in the emergence of opinion controversies [PDF]

, 2017
Understanding the emergence of strong controversial issues in modern societies is a key issue in opinion studies. A commonly diffused idea is the fact that the increasing of homophily in social networks, due to the modern ICT, can be a driving force for ...
Gandica, Y., Gargiulo, F.
core   +4 more sources

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes

Molecular Systems Biology, 2018
Over the past few years, tools that make use of the Cas9 nuclease have led to many breakthroughs, including in the control of gene expression. The catalytically dead variant of Cas9 known as dCas9 can be guided by small RNAs to block transcription of ...
Antoine Vigouroux, Enno Oldewurtel, Lun Cui, David Bikard, Sven van Teeffelen   +4 more
doaj   +1 more source

Analysis of Gram-negative Bacteria Peptidoglycan by Ultra-performance Liquid Chromatography

Bio-Protocol, 2020
Bacteria are surrounded by a protective peptidoglycan cell wall. Provided that this structure and the enzymes involved are the preferred target for our most successful antibiotics, determining its structural and chemical complexity is of the highest ...
Laura Alvarez, Baptiste Cordier, Sven van Teeffelen, Felipe Cava   +3 more
doaj   +1 more source

Turing Patterns and Biological Explanation [PDF]

, 2017
Turing patterns are a class of minimal mathematical models that have been used to discover and conceptualize certain abstract features of early biological development.
Amundson, Baker, Baker, Baron, Batterman, Bechtel, Bechtel, Bechtel, Bourgine, Brigandt, Brigandt, Cooper, Craver, Dilão, Dretske, Economou, Fox Keller, Horvath, Kondo, Lange, Levy, Love, Love, Love, Madzvamuse, Maini, Maini, Meinhardt, Meinhardt, Murray, Murray, Nathan, Othmer, Pincock, Pincock, Pincock, Pincock, Pincock, Sauer, Tompkins, Weisberg, Winther, Woody   +42 more
core   +2 more sources

A Unifying Theory of Branching Morphogenesis

Cell, 2017
Summary The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology ...
É. Hannezo, C. Scheele, M. Moad, Nicholas Drogo, R. Heer, R. Sampogna, J. van Rheenen, B. Simons   +7 more
semanticscholar   +1 more source

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Endothelial EphB4 maintains vascular integrity and transport function in adult heart

eLife, 2019
The homeostasis of heart and other organs relies on the appropriate provision of nutrients and functional specialization of the local vasculature. Here, we have used mouse genetics, imaging and cell biology approaches to investigate how homeostasis in ...
Guillermo Luxán, Jonas Stewen, Noelia Díaz, Katsuhiro Kato, Sathish K Maney, Anusha Aravamudhan, Frank Berkenfeld, Nina Nagelmann, Hannes CA Drexler, Dagmar Zeuschner, Cornelius Faber, Hermann Schillers, Sven Hermann, John Wiseman, Juan M Vaquerizas, Mara E Pitulescu, Ralf H Adams   +16 more
doaj   +1 more source

YAP1 and TAZ negatively control bone angiogenesis by limiting hypoxia-inducible factor signaling in endothelial cells

eLife, 2020
Blood vessels are integrated into different organ environments with distinct properties and physiology (Augustin and Koh, 2017). A striking example of organ-specific specialization is the bone vasculature where certain molecular signals yield the ...
Kishor K Sivaraj, Backialakshmi Dharmalingam, Vishal Mohanakrishnan, Hyun-Woo Jeong, Katsuhiro Kato, Silke Schröder, Susanne Adams, Gou Young Koh, Ralf H Adams   +8 more
doaj   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source