Echocardiographic assessment of Xenopus tropicalis heart regeneration [PDF]
Cell & Bioscience, 2023 Background Recently, it was reported that the adult X. tropicalis heart can regenerate in a nearly scar-free manner after injury via apical resection. Thus, a cardiac regeneration model in adult X. tropicalis provides a powerful tool for recapitulating a
Luocheng Lv +13 more
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Evolutionary divergence in tail regeneration between Xenopus laevis and Xenopus tropicalis [PDF]
Cell & Bioscience, 2021 Tissue regeneration is of fast growing importance in the development of biomedicine, particularly organ replacement therapies. Unfortunately, many human organs cannot regenerate.
Shouhong Wang, Yun-Bo Shi
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Modelling human genetic disorders in Xenopus tropicalis [PDF]
Disease Models & MechanismsABSTRACT Recent progress in human disease genetics is leading to rapid advances in understanding pathobiological mechanisms. However, the sheer number of risk-conveying genetic variants being identified demands in vivo model systems that are amenable to functional analyses at scale. Here we provide a practical guide for using the diploid
Helen Rankin Willsey +5 more
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A comparative analysis of transcription factor expression during metazoan embryonic development. [PDF]
PLoS ONE, 2013 During embryonic development, a complex organism is formed from a single starting cell. These processes of growth and differentiation are driven by large transcriptional changes, which are following the expression and activity of transcription factors ...
Alicia N Schep, Boris Adryan
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CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis [PDF]
Cell & BioscienceThe Xenopus tropicalis (Western clawed frog) is an important amphibian model for genetics, developmental and regenerative biology, due to its diploid genetic background and short generation time.
Xiao-Lin Lin +13 more
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Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line [PDF]
npj Regenerative MedicineCardiomyocyte proliferation in adult Xenopus tropicalis during heart regeneration has remained largely contentious due to the absence of genetic evidence.
Xiao-Lin Lin +8 more
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Developing immortal cell lines from Xenopus embryos, four novel cell lines derived from Xenopus tropicalis [PDF]
Open Biology, 2022 The diploid anuran Xenopus tropicalis has emerged as a key research model in cell and developmental biology. To enhance the usefulness of this species, we developed methods for generating immortal cell lines from Nigerian strain (NXR_1018, RRID ...
Gary J. Gorbsky +8 more
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Xenopus Hybrids Provide Insight Into Cell and Organism Size Control [PDF]
Frontiers in Physiology, 2018 Determining how size is controlled is a fundamental question in biology that is poorly understood at the organismal, cellular, and subcellular levels. The Xenopus species, X. laevis and X. tropicalis differ in size at all three of these levels.
Romain Gibeaux +4 more
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Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis [PDF]
Scientific Reports, 2023 Cancer treatment is still challenging because the disease is often caused by multiple mutations. Although genomic studies have identified many oncogenes and tumor suppressor genes, gene sets involved in tumorigenesis remain poorly understood.
Kazuki Kitamura +9 more
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An epigenetic clock for Xenopus tropicalis. [PDF]
NPJ AgingAbstract DNA methylation clocks have been widely used for accurate age prediction, but most studies have been carried out on mammals. Here we present an epigenetic clock for the aquatic frog Xenopus tropicalis, a widely used model organism in developmental biology and genomics.
Bennett R +4 more
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