Results 1 to 10 of about 58,345 (189)

CRISPR/Cas-mediated mRNA knockdown in the embryos of Xenopus tropicalis [PDF]

Cell & Bioscience
The Xenopus tropicalis (Western clawed frog) is an important amphibian model for genetics, developmental and regenerative biology, due to its diploid genetic background and short generation time.
Xiao-Lin Lin, Yi-Min Zhou, Ke Meng, Jia-Yi Yang, Han Zhang, Jin-Hua Lin, Hai-Yan Wu, Xiao-Yu Wang, Hui Zhao, Shan-Shan Feng, Kyu-Sang Park, Dong-Qing Cai, Li Zheng, Xu-Feng Qi   +13 more
doaj   +3 more sources

Cardiomyocyte proliferation and heart regeneration in adult Xenopus tropicalis evidenced by a transgenic reporter line [PDF]

npj Regenerative Medicine
Cardiomyocyte proliferation in adult Xenopus tropicalis during heart regeneration has remained largely contentious due to the absence of genetic evidence.
Xiao-Lin Lin, Jin-Hua Lin, Yan Cao, Han Zhang, Si-Yi He, Hai-Yan Wu, Ze-Bing Ye, Li Zheng, Xu-Feng Qi   +8 more
doaj   +3 more sources

Echocardiographic assessment of Xenopus tropicalis heart regeneration [PDF]

Cell & Bioscience, 2023
Background Recently, it was reported that the adult X. tropicalis heart can regenerate in a nearly scar-free manner after injury via apical resection. Thus, a cardiac regeneration model in adult X. tropicalis provides a powerful tool for recapitulating a
Luocheng Lv, Weimin Guo, Wei Guan, Yilin Chen, Ruijin Huang, Ziqiang Yuan, Qin Pu, Shanshan Feng, Xin Zheng, Yanmei Li, Luanjuan Xiao, Hui Zhao, Xufeng Qi, Dongqing Cai   +13 more
doaj   +4 more sources

Revealing mitf functions and visualizing allografted tumor metastasis in colorless and immunodeficient Xenopus tropicalis [PDF]

Communications Biology
Transparent immunodeficient animal models not only enhance in vivo imaging investigations of visceral organ development but also facilitate in vivo tracking of transplanted tumor cells.
Rensen Ran, Lanxin Li, Tingting Xu, Jixuan Huang, Huanhuan He, Yonglong Chen   +5 more
doaj   +3 more sources

Identification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis [PDF]

Scientific Reports, 2023
Cancer treatment is still challenging because the disease is often caused by multiple mutations. Although genomic studies have identified many oncogenes and tumor suppressor genes, gene sets involved in tumorigenesis remain poorly understood.
Kazuki Kitamura, Takayoshi Yamamoto, Haruki Ochi, Makoto Suzuki, Nanoka Suzuki, Takeshi Igawa, Tadashi Yoshida, Mitsuru Futakuchi, Hajime Ogino, Tatsuo Michiue   +9 more
doaj   +2 more sources

Melanin deposition and key molecular features in Xenopus tropicalis oocytes [PDF]

BMC Biology
Background Melanin pigmentation in oocytes is a critical feature for both the esthetic and developmental aspects of oocytes, influencing their polarity and overall development.
Hongyang Yi, Weizheng Liang, Sumei Yang, Han Liu, Jiayu Deng, Shuhong Han, Xiaohui Feng, Wenjie Cheng, Yonglong Chen, Jing Hang, Hongzhou Lu, Rensen Ran   +11 more
doaj   +2 more sources

Expanding the CRISPR/Cas genome-editing scope in Xenopus tropicalis [PDF]

Cell & Bioscience, 2022
Background The true diploid frog, Xenopus tropicalis (X. tropicalis) is an excellent genetic model organism. To date, the CRISPR/Cas-mediated genome editing methods established in this species are mostly based on SpCas9 that requires the stringent NGG ...
Zhaoying Shi, Hao Jiang, Guanghui Liu, Songyuan Shi, Xuan Zhang, Yonglong Chen   +5 more
doaj   +2 more sources

The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin [PDF]

Scientific Reports
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms.
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton   +10 more
doaj   +3 more sources

Liver-specific enhancers evolved from independent episodes of MITE domestication in Xenopus tropicalis [PDF]

Mobile DNA
Transposable elements (TEs) occupy a significant fraction of a wide variety of eukaryotic genomes and can be domesticated into functional sequences harbouring a coding or regulatory potential.
Japhet Rojas, Héctor Castillo, Marco Mundaca, Jorge Fraga, Clément Gilbert, Braulio Valdebenito-Maturana, Sylvain Marcellini   +6 more
doaj   +2 more sources

Pharmacological Modulation of Melanocortin 1 Receptor Signaling by Mrap Proteins in Xenopus tropicalis [PDF]

Frontiers in Endocrinology, 2022
The melanocortin system consists of five G protein–coupled receptors (MC1R-MC5R), the bidirectional endogenous ligands (MSH and Agouti families), and accessory proteins (MRAP1 and MRAP2).
Xiaolu Tai, Yaqun Zhang, Jindong Yao, Xuan Li, Jun Liu, Jiazhen Han, Jianjun Lyu, Gufa Lin, Chao Zhang   +8 more
doaj   +2 more sources